Primary Hypercholesterolemia (DBCOND0033454)

Identifiers

Synonyms
Type IIa hyperlipidaemia / Dyslipidemia (Fredrickson Type Ⅱa) / Type IIa Hypercholesterolemia / Primary Hypercholesterolaemia / Familial Hypercholesterolaemia / Familial Hypercholesterolemia / Hypercholesterolemia, Familial / Type IIa hyperlipidemia / Primary hypercholesterolemia / Pure hypercholesterolemia, unspecified / Type IIa hyperlipoproteinemia / Hyperlipoproteinemia Type IIa / Fredrickson Type IIa hyperlipoproteinemia / Fredrickson type IIa hyperlipoproteinemia (disorder) / Type IIa hyperlipoproteinaemia / Fredrickson Type IIa hyperlipoproteinaemia / Fredrickson Type IIa hyperlipidemia / Fredrickson Type IIa hyperlipidaemia / Fredrickson Type IIa lipidemia / Fredrickson Type IIa lipidaemia / Primary hypercholesterolemia (disorder) / Type II lipidemia / Type II lipidaemia / Hyperlipoproteinemia Type II / Familial hypercholesterolemia (disorder) / Hyperbetalipoproteinemia (disorder) / Type II hyperlipoproteinaemia / Type II hyperlipoproteinemia / Fredrickson Type II hyperlipidaemia / Fredrickson Type II lipidemia / Fredrickson Type II hyperlipidemia / Type II hyperlipidaemia / Fredrickson Type II lipidaemia / Type II hyperlipidemia

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amlodipine
A calcium channel blocker used to treat hypertension and angina.
Atorvastatin
An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Bezafibrate
A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
Cholestyramine
A bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
Colestipol
A bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
Fenofibrate
A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
Fenofibric acid
A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
Fluvastatin
An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Inclisiran
A PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels.
Lovastatin
An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke.
Niacin
A B vitamin used to treat hypertriglyceridemia and pellagra.
Rosuvastatin
An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02066207
CKD-337 Drug Interaction Studytreatment1completed
NCT00396240
ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL Goalstreatment4withdrawn
NCT00269204
Lipid Efficacy/Tolerability Study (0524A-020)treatment3completed
NCT02009787
Efficacy Study of Vitamin D and Statins to Treat HypercholesterolemiatreatmentNot Availableunknown_status
NCT00871351
Evaluation of Ezetimibe and Atorvastatin Coadministration Versus Atorvastatin or Rosuvastatin Monotherapy in Japanese Patients With Hypercholesterolemia (Study P06027)(COMPLETED)treatment4completed
NCT05131997
A Study to Evaluate the Efficacy and Safety of AD-221 and AD-221Atreatment3completed
NCT01294683
A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118)treatment3terminated
NCT05930028
A Study to Evaluate the Efficacy and Safety of BR1017A and BR1017B Combination Therapy in Essential Hypertension Patients With Primary Hypercholesterolemiatreatment3recruiting
NCT00479388
Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067)treatment3completed
NCT05559606
An OS to Evaluate the Safety & Efficacy of Fixed Dose Combination Therapy With Atorvastatin and EzetimibeNo drug interventionsNot AvailableNot Availablerecruiting
NCT02205606
Efficacy/Safety of HCP1306 Tablet Versus HGP0816 Tablet in Patients With Primary HypercholesterolemiaNo drug interventionstreatment3completed
NCT04652349
Efficacy and Safety of HGP1910 and HCP1903 in Patients With Primary HypercholesterolemiaNo drug interventionstreatment3completed
NCT04584736
To Evaluate the Efficacy and Safety in Patients With Primary Hypercholesterolemiatreatment3completed
NCT01879319
Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pentreatment3completed
NCT06314919
A Study to Evaluate the Efficacy and Safety of Fixed-Dose Combination of Pitavastatin/EzetimibNo drug interventionsNot AvailableNot Availablerecruiting
NCT06386419
A Clinical Study to Evaluate the Safety and Effectiveness of Inclisiran Sodium in Indian Patients With Primary Hypercholesterolemia or Mixed Dyslipidemiatreatment4not_yet_recruiting
NCT02087917
A 4-week, Randomized, Placebo-Controlled, Double-Blind, Efficacy and Safety Study of HS-25 in Adults With Primary HypercholesterolemiaNo drug interventionstreatment2completed
NCT00269217
Lipid Efficacy Study (0524B-022)(COMPLETED)treatment3completed
NCT00704535
Evaluation of the Safety, Tolerability and Efficacy of Ezetimibe on a Select Population of Filipinos With Hypercholesterolemia (Study P04748)(COMPLETED)Not AvailableNot Availablecompleted
NCT05118230
Study to Assess the Real World Effectiveness of Inclisiran in Chinese Adult Patients With Primary Hypercholesterolemia or Mixed DyslipidemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02941848
Evaluate the Pharmacokinetics and Safety of HCP1306 and Co-administration of HGP0816, HGP1404 in Healthy Male VolunteersNo drug interventionstreatment1completed
NCT05657574
A Clinical Trial to Evaluate the Efficacy and Safety of CKD-391 and CKD-331 in Patients With Primary HypercholesterolemiaNo drug interventionstreatment3recruiting
NCT00479882
MK-0524B Lipid Study (MK-0524B-063)treatment3completed
NCT03413462
Efficacy and Safety Study of HS-25 in Chinese Adults With Primary HypercholesterolemiaNo drug interventionstreatment3completed
NCT05399992
Study Evaluating Effectiveness and Adherence of Inclisiran Plus Standard of Care (SoC) Lipid-lowering Therapy Compared to SoC in ASCVDNo drug interventionsNot AvailableNot Availablerecruiting
NCT06165250
A Study to Evaluate the Efficacy and Safety of Co-administrated BR1018B and BR1018CNo drug interventionstreatment3recruiting
NCT00941603
Phase 2 Dose-Ranging Efficacy and Safety Trial of SCH 900271 in Participants With Primary Hypercholesterolemia or Mixed Hyperlipidemia (P05675)treatment2completed
NCT03571087
Efficacy and Safety of Combination of Rosuvastatin and Ezetimibe in Patients With Primary Hypercholesterolemiatreatment3completed
NCT00724477
Retrospective Evaluation of the Percentage of Subjects Who Have Reached Their LDL-C Objectives After Treatment With INEGY (Study P05103)(COMPLETED)No drug interventionsNot AvailableNot Availablecompleted
NCT03882905
A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173)treatment3completed
NCT01335997
Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143)treatment3terminated
NCT01849497
Study to Assess In-home Use of Evolocumab (AMG 145) Using a Prefilled Syringe or a Prefilled Autoinjector/Pentreatment3completed
NCT00746811
Effects of Prescription Omega-3 on LDL-C in Primary Hypercholesterolemiatreatment4completed
NCT04643093
Compare the Efficacy and Safety of 1PC111 With Pitavastatin and Ezetimibe in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemiatreatment3completed
NCT06568471
A Study on Efficacy and Safety of HST101 in Chinese Patients With Hypercholesterolemiatreatment3not_yet_recruiting
NCT05206578
Study to Evaluate the Efficacy and Safety in Patients With Primary HypercholesterolemiaNo drug interventionstreatment3unknown_status
NCT02445352
Efficacy/Safety of DP-R207 Tablet Versus CRESTOR Tablet in Patients With Primary Hypercholesterolemiatreatment3completed
NCT04849000
Study of SHR-1209 in the Treatment of Hypercholesterolemia and Hyperlipidemia Ⅲ Stagetreatment3completed
NCT01274559
Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133)treatment3terminated
NCT04659070
To Evaluate the Efficacy and Safety of Co-administrated Ezetimibe/Rosuvastatin and Telmisartan in Patients With Essential Hypertension and Primary Hypercholesterolemiatreatment3unknown_status
NCT00249249
Study to Compare the Efficacy of Pitavastatin With That of Atorvastatin in Lowering Cholesterol Levelstreatment3completed
NCT01012219
A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED)treatment1completed
NCT04844125
SHR - 1209 Treatment Efficacy and Safety of the Patients With Hypercholesterolemia Ⅲ Period Clinical Researchtreatment3completed
NCT00867165
Pediatric Study to Evaluate the Efficacy and Safety of Ezetimibe Monotherapy in Children With Primary Hypercholesterolemia (P05522)treatment3completed
NCT03464682
Efficacy and Safety of HS-25 or in Combination With Atorvastatin in Chinese Adults With Primary Hypercholesterolemiatreatment3unknown_status
NCT06448962
Phase 3 Study to Evaluate the Efficacy and Safety of Co-administrated AD-2021 and AD-2022No drug interventionstreatment3completed
NCT06475872
Study to Evaluate the Bioequivalence of "Crecheck Tablet 2.5 mg (Rosuvastatin Calcium)" and "Crestor Tablet 5 mg (Rosuvastatin Calcium)" in Healthy Adult Subjectstreatment1completed
NCT06184269
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1017-1" and Co-administration of "BR1017-1A" and "BR1017-1B"No drug interventionstreatment1completed
NCT03952169
Effect of Probiotics on Lipid ManagementNo drug interventionspreventionNot Availableunknown_status
NCT03433755
Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Participants With Primary Hypercholesterolemia and Mixed Dyslipidemiatreatment3terminated
NCT03516955
Efficacy and Safety of a Generic Rosuvastatin in a Real-world SettingNot AvailableNot Availablecompleted
NCT05798390
Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed DyslipidemiaNot AvailableNot Availablewithdrawn
NCT00776321
Eprotirome for the Treatment of Dyslipidemia, Efficacy and Safety 12-Week, Phase ii Study to Assess the Safety and Efficacy of KB2115 in Patients With Primary Hypercholesterolemiaprevention2completed
NCT05638022
Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech RepublicNo drug interventionsNot AvailableNot Availableunknown_status
NCT01577056
Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish OilsNo drug interventionstreatmentNot Availableunknown_status
NCT01078675
An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemiatreatment3completed
NCT06275724
Specified Drug-use Survey of Leqvio for s.c. Injection.No drug interventionsNot AvailableNot Availablerecruiting
NCT02693548
The Spanish Familial Hypercholesterolaemia Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05181553
Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.No drug interventionspreventionNot Availablerecruiting
NCT02489253
Atherosclerosis in Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT05746247
Improving Diagnosis and Clinical Management of Familial Hypercholesterolemia Through Integrated Machine Learning, Implementation Science, and Behavioral EconomicsNo drug interventionsdiagnosticNot Availableenrolling_by_invitation
NCT05425745
Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.treatment3completed
NCT05271305
Pilot Study for a National Screening for Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT05218005
Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemiaNo drug interventionsdiagnosticNot Availablerecruiting
NCT04272697
EAS Familial Hypercholesterolaemia Studies CollaborationNo drug interventionsNot AvailableNot Availablerecruiting
NCT04656028
Genetic Testing and Motivational Counseling for FHNo drug interventionstreatmentNot Availablerecruiting
NCT01138371
Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid MarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT03152656
A Registration Study for Familial Hypercholesterolemia in TaiwanNo drug interventionsNot AvailableNot Availableunknown_status
NCT03832985
Pediatric Reporting of Adult-Onset Genomic ResultsNo drug interventionshealth_services_research0active_not_recruiting
NCT05695937
Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial HypercholesterolemiaNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06546137
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter RegistryNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03253432
IN-TANDEM Familial Hypercholesterolemia Pilot StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05066932
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00827606
Atorvastatin Three Year Pediatric Studytreatment3completed
NCT04101149
Genetic Causes of Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05284513
Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)No drug interventionsotherNot Availableenrolling_by_invitation
NCT02013713
French Observatory of Familial Hypercholesterolemia in CardiologyNo drug interventionsNot AvailableNot Availableterminated
NCT05614219
Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.No drug interventionsscreeningNot Availablenot_yet_recruiting
NCT00924339
Soy Food Intervention TrialNo drug interventionstreatmentNot Availableunknown_status
NCT05142722
Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapiestreatment3active_not_recruiting
NCT06389825
Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.No drug interventionstreatmentNot Availablerecruiting
NCT06571630
PMMHRI - Familial Hypercholesterolemia RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02729857
Postprandial Response After Intake of Meals With Different Fatty Acid CompositionNo drug interventionspreventionNot Availablecompleted
NCT04929457
Evaluation of a Digiphysical Screening Method to Identify and Diagnose Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03331666
Impact of LDL-cholesterol Lowering on Platelet Activationprevention4terminated
NCT04458766
The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in AdolescentsNo drug interventionstreatmentNot Availablecompleted
NCT00655265
A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-on Therapy to Their Existing Medicationtreatment4completed
NCT00924274
Effect of Rapeseed Oil and Sunflower OilNo drug interventionstreatmentNot Availableunknown_status
NCT03934320
Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT)No drug interventionsdiagnosticNot Availableunknown_status
NCT06362473
Lipid Transport Disorder Italian Genetic Record (LIPIGEN)No drug interventionsNot AvailableNot Availablerecruiting
NCT02750527
Pediatric Population Screening for Type 1 Diabetes and Familial Hypercholesterolemia in Lower Saxony, GermanyNo drug interventionsNot AvailableNot Availablecompleted
NCT02870660
Familial Hypercholesterolemia Amongst Patients With Acute Coronary SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT02865694
Developing and Implementing Familial Hypercholesterolemia RegistryNo drug interventionsNot AvailableNot Availableunknown_status
NCT06293729
Safety and Efficacy Study of NGGT006 in Refractory Hypercholesterolemia PatientsNo drug interventionstreatment0not_yet_recruiting
NCT00704444
A 12-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combination With Other Lipid-lowering Drugs in Japanese Subjects With Hypercholesterolemia (Study P05244)Not AvailableNot Availablecompleted
NCT04529967
Child-Parent Familial Hypercholesterolemia ScreeningNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02208869
Russian Familial Hypercholesterolemia RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02624869
Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)treatment3completed
NCT00079846
Implitapide in Patients With Homozygous Familial Hypercholesterolemia (HoFH) on Maximal Concurrent Lipid-Lowering Therapytreatment2terminated
NCT02048410
Efficacy of a New Symbiotic Formulation in Children With Familial HypercholesterolemiaNo drug interventionstreatment1 / 2completed
NCT06458010
Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)No drug interventionstreatment0recruiting
NCT04455581
A Study to Determine the Safety, Tolerability, and Efficacy of SHR-1209 in Patients With Familial Hypercholesterolemiatreatment2unknown_status
NCT06331195
An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03110250
Familial Hypercholesterolemia in Turkey (A-HIT2)No drug interventionsNot AvailableNot Availablecompleted
NCT02709850
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS ANGPTL3-LRx in Healthy Volunteers With Elevated Triglycerides and Participants With Familial HypercholesterolemiaNo drug interventionsother1completed
NCT00751608
Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia PatientsNo drug interventionsbasic_science2withdrawn
NCT01107743
Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan)Not AvailableNot Availablecompleted
NCT02808403
Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in JapanNo drug interventionsNot AvailableNot Availablecompleted
NCT04507984
Universal Familial Hypercholesterolemia Screening in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT05758779
The Danish Familial Hypercholesterolemia Organized Coronary Screening TrialNo drug interventionspreventionNot Availablerecruiting
NCT03756779
Cross-over Pilot Study of Blood Cholesterol Response to Dietary Saturated Fat in Patients With Autosomal Dominant HypercholesterolemiaNo drug interventionstreatmentNot Availablewithdrawn
NCT06439654
Atlantic Lipid Lowering Treatment Optimization ProgramNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT03398954
a Prospective Pilot Study of Screening Out Rate and Clinical Management of Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT03060577
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesteroltreatment2completed
NCT02009345
Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale CanadaNo drug interventionsNot AvailableNot Availablerecruiting
NCT03140605
Greek Registry - Familial HypercholesterolaemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT01783405
Cardiovascular Disease in FH HeterozygousNo drug interventionsNot AvailableNot Availableunknown_status
NCT06005597
Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapiestreatment3active_not_recruiting
NCT00705211
A 52-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combination With Other Lipid-lowering Drugs in Japanese Subjects With Hypercholesterolemia (Study P05245)Not AvailableNot Availablecompleted
NCT03310671
Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With StatinsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05465278
Alirocumab and Plaque Burden In Familial Hypercholesterolaemiatreatment4completed
NCT00004809
Phase I Study of Ex Vivo Liver-Directed Gene Therapy for Familial HypercholesterolemiaNo drug interventionstreatment1completed
NCT05952856
A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef LipidsNo drug interventionstreatment3active_not_recruiting
NCT00355615
PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatintreatment3completed
NCT03884452
Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018)treatment3completed
NCT00079859
Implitapide in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) on Maximal Concurrent Lipid-Lowering Therapytreatment2terminated
NCT04941599
2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)prevention2recruiting
NCT04370899
Early Detection of Familial Hypercholesterolemia in ChildrenNo drug interventionsNot AvailableNot Availablerecruiting
NCT01813006
Effect of Omega-3 Fatty Acid on Endothelial Functiontreatment3completed
NCT00943306
Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemiatreatment3completed
NCT05238519
Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH)No drug interventionsscreening3recruiting
NCT03640234
Return of Actionable Variants Empirical StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03747224
Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patientstreatment1completed
NCT03597958
Genetic Causes of Hypercholesterolaemia in the Emirati PopulationNo drug interventionsNot AvailableNot Availableunknown_status
NCT05352386
Coronary and Heart Effects of Early Treatment in Familial HypercholesterolemiaNo drug interventionsdiagnosticNot Availablecompleted
NCT04798430
Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reductiontreatment3enrolling_by_invitation
NCT02748057
A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)treatment3completed
NCT05261126
A Study of the Efficacy and Safety of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008)No drug interventionstreatment2completed
NCT05851066
A VSA003 Phase 1 Study in Chinese Adult Healthy VolunteersNo drug interventionstreatment1not_yet_recruiting
NCT02597127
Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)treatment2completed
NCT05430191
Equitable Implementation of Cascade Screening for Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT04958629
A Prospective Cohort Study on Familial Hypercholesterolemia in Health Examination PopulationNo drug interventionsNot AvailableNot Availableunknown_status
NCT02225340
Relationships Between Plasma PCSK9 Levels, LDL-cholesterol Concentrations and Lipoprotein (a) Levels in Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT05750667
Penn Family Screening for Familial HypercholesterolemiaNo drug interventionshealth_services_researchNot Availableenrolling_by_invitation
NCT03900169
Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent PpciNo drug interventionsNot AvailableNot Availableunknown_status
NCT05952869
A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017) CORALreef HeFHNo drug interventionstreatment3active_not_recruiting
NCT02778646
Detection of Familial Hypercholesterolaemia in Cardiovascular Disease RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT05825612
EPIRUS FH Reverse Cascade ScreeningNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05367310
Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05043181
Exosome-based Nanoplatform for Ldlr mRNA Delivery in FHNo drug interventionstreatment1not_yet_recruiting
NCT02462655
Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial HypercholesterolemiaNo drug interventionstreatmentNot Availablecompleted
NCT00916643
Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. TherapyNo drug interventionstreatment4completed
NCT04419090
Cascade Genetic Testing of Familial HypercholesterolemiaNo drug interventionsscreeningNot Availablecompleted
NCT04494464
Treatment Rates and Compliance to Treatment in Patients With Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT05348564
Comparing Direct vs Indirect Methods for Cascade ScreeningNo drug interventionsscreeningNot Availablerecruiting
NCT06461702
Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)No drug interventionstreatment0recruiting
NCT00092833
Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED)treatment3terminated
NCT01375751
Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Studytreatment2completed
NCT00384293
Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED)treatment3terminated
NCT00515307
Bone Marrow Stem Cells as a Source of Allogenic Hepatocyte Transplantation in Homozygous Familial HypercholesterolemiaNo drug interventionstreatment1completed
NCT00134485
Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial Hypercholerolemiatreatment3completed
NCT04526457
Is Family Screening Improved by Genetic Testing of Familial HypercholesterolemiaNo drug interventionsotherNot Availablecompleted
NCT00000594
NHLBI Type II Coronary Intervention Studyprevention3completed
NCT01524289
Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)treatment3completed
NCT03989167
Clinical Decision Support for Familial HypercholesterolemiaNo drug interventionsdiagnosticNot Availablerecruiting
NCT00005168
Hyperapo B and Coronary Heart DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04722068
Regeneron 1331 Kinetics Sub-Study HoFHNo drug interventionsotherNot Availablecompleted
NCT00136981
Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.treatment3completed
NCT00281008
Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering TherapyNo drug interventionstreatment2completed
NCT04837638
Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01583647
A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158)treatment1terminated
NCT04073797
PET Imaging of Inflammation and Lipid Lowering StudydiagnosticNot Availablerecruiting
NCT00134511
Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol Disordertreatment3completed
NCT03018678
Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01753232
Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein FilterNo drug interventionsNot AvailableNot Availablecompleted
NCT06231459
Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemiatreatment4completed
NCT04313270
Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®Not AvailableNot Availablerecruiting
NCT04118348
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