Resistance or intolerance to prior therapy

Drugs
Drugs and Targets

Drug	Drug Name	Drug Description
DB00307	Bexarotene	A retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.
DB06616	Bosutinib	An antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
DB01254	Dasatinib	A tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
DB00997	Doxorubicin	A medication used to treat various cancers, including AIDS-associated Kaposi's Sarcoma and metastatic cancers.
DB15569	Sotorasib	An experimental KRAS inhibitor being investigated for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer.

Drug	Drug Name	Target	Type
DB00307	Bexarotene	Retinoic acid receptor RXR-beta	target
DB00307	Bexarotene	Cytochrome P450 3A4	enzyme
DB00307	Bexarotene	Retinoic acid receptor RXR-alpha	target
DB00307	Bexarotene	Retinoic acid receptor RXR-gamma	target
DB00307	Bexarotene	Cytochrome P450 2C8	enzyme
DB06616	Bosutinib	Tyrosine-protein kinase ABL1	target
DB06616	Bosutinib	Tyrosine-protein kinase Lyn	target
DB06616	Bosutinib	Proto-oncogene tyrosine-protein kinase Src	target
DB06616	Bosutinib	P-glycoprotein 1	transporter
DB06616	Bosutinib	Cytochrome P450 3A4	enzyme
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 1	target
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 2	target
DB06616	Bosutinib	Mitogen-activated protein kinase kinase kinase 2	target
DB06616	Bosutinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	target
DB06616	Bosutinib	Cytochrome P450 2C8	enzyme
DB06616	Bosutinib	Tyrosine-protein kinase Fgr	target
DB06616	Bosutinib	Tyrosine-protein kinase HCK	target
DB06616	Bosutinib	Tyrosine-protein kinase Tec	target
DB06616	Bosutinib	STE20-like serine/threonine-protein kinase	target
DB01254	Dasatinib	Tyrosine-protein kinase ABL1	target
DB01254	Dasatinib	Tyrosine-protein kinase ABL2	target
DB01254	Dasatinib	Proto-oncogene tyrosine-protein kinase Src	target
DB01254	Dasatinib	Tyrosine-protein kinase Fyn	target
DB01254	Dasatinib	Tyrosine-protein kinase Lck	target
DB01254	Dasatinib	Tyrosine-protein kinase Yes	target
DB01254	Dasatinib	Mast/stem cell growth factor receptor Kit	target
DB01254	Dasatinib	Platelet-derived growth factor receptor beta	target
DB01254	Dasatinib	Ephrin type-A receptor 2	target
DB01254	Dasatinib	Signal transducer and activator of transcription 5B	target
DB01254	Dasatinib	Cytochrome P450 3A4	enzyme
DB01254	Dasatinib	P-glycoprotein 1	transporter
DB01254	Dasatinib	ATP-binding cassette sub-family G member 2	transporter
DB01254	Dasatinib	Cytochrome P450 1A1	enzyme
DB01254	Dasatinib	Cytochrome P450 1A2	enzyme
DB01254	Dasatinib	Cytochrome P450 1B1	enzyme
DB01254	Dasatinib	Cytochrome P450 3A5	enzyme
DB01254	Dasatinib	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
DB01254	Dasatinib	Tyrosine-protein kinase BTK	target
DB01254	Dasatinib	Nuclear receptor subfamily 4 group A member 3	target
DB01254	Dasatinib	Breakpoint cluster region protein	target
DB01254	Dasatinib	Tyrosine-protein kinase CSK	target
DB01254	Dasatinib	Ephrin type-A receptor 5	target
DB01254	Dasatinib	Ephrin type-B receptor 4	target
DB01254	Dasatinib	Tyrosine-protein kinase Fgr	target
DB01254	Dasatinib	Tyrosine-protein kinase FRK	target
DB01254	Dasatinib	Heat shock cognate 71 kDa protein	target
DB01254	Dasatinib	Tyrosine-protein kinase Lyn	target
DB01254	Dasatinib	Mitogen-activated protein kinase kinase kinase MLT	target
DB01254	Dasatinib	Mitogen-activated protein kinase 14	target
DB01254	Dasatinib	Amidophosphoribosyltransferase	target
DB00997	Doxorubicin	DNA topoisomerase 2-alpha	target
DB00997	Doxorubicin	DNA	target
DB00997	Doxorubicin	Cytochrome P450 3A4	enzyme
DB00997	Doxorubicin	Cytochrome P450 2D6	enzyme
DB00997	Doxorubicin	Cytochrome P450 2B6	enzyme
DB00997	Doxorubicin	P-glycoprotein 1	transporter
DB00997	Doxorubicin	Canalicular multispecific organic anion transporter 2	transporter
DB00997	Doxorubicin	Multidrug resistance-associated protein 6	transporter
DB00997	Doxorubicin	Multidrug resistance-associated protein 1	transporter
DB00997	Doxorubicin	Multidrug resistance-associated protein 7	transporter
DB00997	Doxorubicin	ATP-binding cassette sub-family G member 2	transporter
DB00997	Doxorubicin	Bile salt export pump	transporter
DB00997	Doxorubicin	Solute carrier family 22 member 16	transporter
DB00997	Doxorubicin	ATP-binding cassette sub-family B member 8, mitochondrial	transporter
DB00997	Doxorubicin	Cytochrome P450 1B1	enzyme
DB00997	Doxorubicin	Carbonyl reductase [NADPH] 1	enzyme
DB00997	Doxorubicin	Carbonyl reductase [NADPH] 3	enzyme
DB00997	Doxorubicin	Alcohol dehydrogenase [NADP(+)]	enzyme
DB00997	Doxorubicin	Aldo-keto reductase family 1 member C3	enzyme
DB00997	Doxorubicin	NAD(P)H dehydrogenase [quinone] 1	enzyme
DB00997	Doxorubicin	Xanthine dehydrogenase/oxidase	enzyme
DB00997	Doxorubicin	Nitric oxide synthase, endothelial	enzyme
DB00997	Doxorubicin	Nitric oxide synthase, inducible	enzyme
DB00997	Doxorubicin	Nitric oxide synthase, brain	enzyme
DB00997	Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	enzyme
DB00997	Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	enzyme
DB00997	Doxorubicin	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	enzyme
DB00997	Doxorubicin	NADPH--cytochrome P450 reductase	enzyme
DB00997	Doxorubicin	RalA-binding protein 1	transporter
DB00997	Doxorubicin	Canalicular multispecific organic anion transporter 1	transporter
DB00997	Doxorubicin	Serum albumin	carrier
DB00997	Doxorubicin	Nucleolar and coiled-body phosphoprotein 1	target
DB00997	Doxorubicin	DNA topoisomerase 1	target
DB00997	Doxorubicin	DNA topoisomerase 2-beta	target
DB00997	Doxorubicin	Aldose reductase	enzyme
DB00997	Doxorubicin	Aldo-keto reductase family 1 member B10	enzyme
DB00997	Doxorubicin	Aldo-keto reductase family 1 member C4	enzyme
DB15569	Sotorasib	GTPase KRas	target
DB15569	Sotorasib	Cytochrome P450 3A Subfamily	enzyme
DB15569	Sotorasib	Cytochrome P450 2C8	enzyme
DB15569	Sotorasib	Cytochrome P450 2C9	enzyme
DB15569	Sotorasib	Cytochrome P450 2B6	enzyme
DB15569	Sotorasib	ATP-binding cassette sub-family G member 2	transporter
DB15569	Sotorasib	P-glycoprotein 1	transporter

Drug	Drug Name	Phase	Status	Count