Depressive Episodes

Also known as: Acute depressive episodes / Depressive Episode / Acute Depressive Episode / Major depressive disorder, single episode, unspecified / Major depressive disorder, single episode / Major depression, single episode (disorder) / Episode of depression (finding) / Feeling down / Mood depression / Mood depressions / Depressed mood / Depressive disorder (disorder) / Low mood / Feeling blue / Dysthymic disorder / Depression, unspecified / Depressive illness / Dysthymia (disorder) / Depressive neurosis / Depressive disorder / Depressive disorders / Major depressive disorder, recurrent, unspecified / Depressive state / Depression NOS / Depressed state / Depression / Depression mental

DrugDrug NameDrug Description
DB06016CariprazineAn atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
DB06077LumateperoneA novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DB01224QuetiapineAn atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
DB00752TranylcypromineA monoamine oxidase inhibitor used to treat major depressive disorder.
DB00313Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
DrugDrug NameTargetType
DB06016CariprazineCytochrome P450 3A4enzyme
DB06016CariprazineCytochrome P450 2D6enzyme
DB06016CariprazineP-glycoprotein 1transporter
DB06016CariprazineCytochrome P450 3A5enzyme
DB06016CariprazineDopamine D3 receptortarget
DB06016CariprazineDopamine D2 receptortarget
DB06016Cariprazine5-hydroxytryptamine receptor 1Atarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Btarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Atarget
DB06016CariprazineHistamine H1 receptortarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Ctarget
DB06016CariprazineAlpha-1A adrenergic receptortarget
DB06016CariprazineCytochrome P450 1A2enzyme
DB06016CariprazineCytochrome P450 2C9enzyme
DB06016CariprazineCytochrome P450 2C19enzyme
DB06016CariprazineCytochrome P450 2E1enzyme
DB06077Lumateperone5-hydroxytryptamine receptor 2Atarget
DB06077LumateperoneDopamine D2 receptortarget
DB06077LumateperoneDopamine D1 receptortarget
DB06077LumateperoneSodium-dependent serotonin transportertarget
DB06077LumateperoneGlutamate receptor ionotropic, NMDA 2Btarget
DB06077LumateperoneAldo-keto reductase familyenzyme
DB06077LumateperoneCytochrome P450 3A4enzyme
DB06077LumateperoneCytochrome P450 2C8enzyme
DB06077LumateperoneCytochrome P450 1A2enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-1enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-4enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 2B15enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C1enzyme
DB06077LumateperoneAldo-keto reductase family 1 member B10enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C4enzyme
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineDopamine D2 receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1 adrenergic receptorstarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineDopamine D5 receptortarget
DB01224QuetiapineDopamine D1 receptortarget
DB01224QuetiapineDopamine D3 receptortarget
DB01224QuetiapineDopamine D4 receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineP-glycoprotein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB00752TranylcypromineAmine oxidase [flavin-containing] Btarget
DB00752TranylcypromineAmine oxidase [flavin-containing] Atarget
DB00752TranylcypromineCytochrome P450 2C19enzyme
DB00752TranylcypromineCytochrome P450 2A6enzyme
DB00752TranylcypromineCytochrome P450 2D6enzyme
DB00752TranylcypromineCytochrome P450 1A2enzyme
DB00752TranylcypromineCytochrome P450 2C9enzyme
DB00752TranylcypromineCytochrome P450 3A4enzyme
DB00313Valproic acidHistone deacetylase 9target
DB00313Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic acidCytochrome P450 2A6enzyme
DB00313Valproic acidCytochrome P450 2B6enzyme
DB00313Valproic acidCytochrome P450 2C9enzyme
DB00313Valproic acidSolute carrier family 22 member 5transporter
DB00313Valproic acidSolute carrier family 22 member 6transporter
DB00313Valproic acidSolute carrier family 22 member 8transporter
DB00313Valproic acidMonocarboxylate transporter 1transporter
DB00313Valproic acidSolute carrier family 22 member 7transporter
DB00313Valproic acidCytochrome P450 3A5enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic acidProstaglandin G/H synthase 1enzyme
DB00313Valproic acidCytochrome P450 1A2enzyme
DB00313Valproic acidCytochrome P450 2C19enzyme
DB00313Valproic acidCytochrome P450 3A4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic acidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic acidSodium channel proteintarget
DB00313Valproic acidHistone deacetylase 2target
DB00313Valproic acidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic acidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic acidSerum albumincarrier
DB00313Valproic acidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic acidSolute carrier organic anion transporter family member 2B1transporter
DB00313Valproic acidHistone deacetylasetarget
DB00313Valproic acidCyclin-dependent kinase inhibitor 1target
DB00313Valproic acidHepatocyte growth factortarget
DB00313Valproic acidOrnithine decarboxylasetarget
DB00313Valproic acidProgrammed cell death 1 ligand 1target
DrugDrug NamePhaseStatusCount
DB01393Bezafibrate2Recruiting1
DB00753Isoflurane2Unknown Status1
DB01221Ketamine2Not Yet Recruiting1
DB19178OSU-61622Recruiting1
DB01104Sertraline2Unknown Status1
DB09289Tianeptine2Completed1
DB01238Aripiprazole3Terminated1
DB00980Ramelteon3Terminated1
DB11823Esketamine4Not Yet Recruiting1
DB09167DosulepinNot AvailableCompleted1
DB01104SertralineNot AvailableCompleted1
DB00285VenlafaxineNot AvailableCompleted1