Dermatomyositis (DM) (DBCOND0047795)

Identifiers

Synonyms
Dermatomyositis / Dermatopolymyositis, unspecified, organ involvement unspecified / Dermatopolymyositis, unspecified / Dermatomyositis (disorder) / Dermatopolymyositis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Betamethasone
A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
Bupivacaine
A local anesthetic used in a wide variety of superficial and invasive procedures.
Human immunoglobulin G
A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders.
Hydrocortisone
A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.
Hydrocortisone succinate
A corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
Methotrexate
An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
Methylprednisolone
A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
Methylprednisolone hemisuccinate
A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
Prednisolone
A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
Tetracosactide
A diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
Triamcinolone
A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06371417
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)No drug interventionstreatment1recruiting
NCT01151644
Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic DiseasesNo drug interventionsprevention4unknown_status
NCT04723303
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)No drug interventionstreatment0completed
NCT04044690
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)treatment3active_not_recruiting
NCT00001421
Methimazole to Treat Polymyositis and Dermatomyositistreatment2completed
NCT05495321
Interleukin-2 on Active Dermatomyositistreatment3enrolling_by_invitation
NCT05239702
Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune DiseasesNo drug interventionstreatment0recruiting
NCT03941184
Spontaneous Coronary Artery Dissection (SCAD) and AutoimmunityNo drug interventionsNot AvailableNot Availablecompleted
NCT00106184
Rituximab for the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM)treatment2completed
NCT00341679
Studies of the Natural History and Pathogenesis of Autoimmune/Connective Tissue DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT03267277
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositistreatment2 / 3completed
NCT02971683
Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathytreatment3completed
NCT04486261
High-intensity Strength Training in MyositisNo drug interventionstreatmentNot Availablecompleted
NCT05833711
Study Evaluating Efficacy and Safety of Froniglutide (PF1801) in Patients With Idiopathic Inflammatory Myopathytreatment2recruiting
NCT03181893
A Study In Adults With Moderate To Severe Dermatomyositistreatment2completed
NCT00005571
Safety and Effectiveness of h5G1.1-mAb for Dermatomyositistreatment2completed
NCT00112385
A Pilot Study of Etanercept in Dermatomyositistreatment1completed
NCT04747652
Clinical Research on Advanced Warning Factors Of Respiratory Injury in DermatomyositisNo drug interventionsNot AvailableNot Availableunknown_status
NCT06154252
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathytreatment1 / 2recruiting
NCT05027152
Muscle Function and Effects of Repetitive Task Training in Patients With Inflammatory MyopatiesNo drug interventionstreatmentNot Availableunknown_status
NCT01276470
Environmental Risk Factors for the Anti-synthetase SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT04628936
Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM.treatment2completed
NCT01432613
Diagnostic Accuracy of Whole Body Magnetic Resonance Imaging in Inflammatory MyopathiesNo drug interventionsdiagnosticNot Availablecompleted
NCT06347718
CAR-T Cells in Systemic B Cell Mediated Autoimmune DiseaseNo drug interventionstreatment1 / 2recruiting
NCT06298019
Study of KYV-101 Anti-CD19 CAR T Therapy in Adult DermatomyositisNo drug interventionstreatment1not_yet_recruiting
NCT01813617
Outcome in Patients With Recent Onset Polymyositis and DermatomyositisNot AvailableNot Availablecompleted
NCT06004817
Evaluation of Severity in Juvenile and Adult-onset DermatomyositisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05832034
Add-on Intravenous Immunoglobulins in Early Myositistreatment2recruiting
NCT00035958
Understanding the Pathogenesis and Treatment of Childhood Onset Dermatomyositistreatment2 / 3terminated
NCT02594735
Abatacept in Juvenile Dermatomyositistreatment4completed
NCT05437263
A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With DermatomyositisNo drug interventionstreatment3active_not_recruiting
NCT06149039
Study on Lymphocyte Subsets of Peripheral Blood in Patients With Nonmyopathic Dermatomyositis Complicated With Pulmonary Interstitial DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT00866125
Hand Function in Patients With Poly- or DermatomyositisNo drug interventionsNot AvailableNot Availablecompleted
NCT02043548
Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositistreatment2completed
NCT00004357
Absorption of Corticosteroids in Children With Juvenile Dermatomyositistreatment2completed
NCT03027674
Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaudtreatment0completed
NCT02418273
Denosumab for Glucocorticoid-treated Children With Rheumatic Disorderstreatment1 / 2withdrawn
NCT03813160
Trial to Evaluate Efficacy and Safety of Lenabasum in Dermatomyositistreatment3completed
NCT04972760
Baricitinib in Patients With Relapsing or naïve Dermatomyositistreatment3recruiting
NCT03981744
A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatmentstreatment3terminated
NCT04976140
Allogeneic Mitochondria (PN-101) Transplantation for Refractory Polymyositis or DermatomyositisNo drug interventionstreatment1 / 2completed
NCT06462768
Neutrophil Extracellular Traps in Different Forms of Systemic SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01734369
Environmental Risk Factors for Myositis in Military PersonnelNo drug interventionsNot AvailableNot Availablecompleted
NCT05695950
A Study Evaluating the Effects of GLPG3667 Given as Oral Treatment for up to 24 Weeks in Adults With DermatomyositisNo drug interventionstreatment2recruiting
NCT01165008
Anakinra in Myositistreatment2 / 3completed
NCT02466243
Safety, Tolerability, and Efficacy of JBT-101 in Subjects With Dermatomyositistreatment2terminated
NCT01140503
A Study to Evaluate the Safety and Efficacy of Apremilast in the Treatment of Skin Disease in Patients With DermatomyositistreatmentNot Availableterminated
NCT01637064
Dermatomyositis and Polymyositis RegistryNot AvailableNot Availableunknown_status
NCT06056921
Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune DiseaseNo drug interventionstreatment1recruiting
NCT06438679
3T Therapy in the Treatment of MDA5-positive Dermatomyositistreatment4enrolling_by_invitation
NCT06284954
A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults with Dermatomyositistreatment2recruiting
NCT02945345
Clinical Responsiveness of Dermatomyositis Using Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI)No drug interventionsNot AvailableNot Availablerecruiting
NCT03816345
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancertreatment1recruiting
NCT02980198
Study of IFN-K in DermatomyositisNo drug interventionstreatment2withdrawn
NCT00001261
Intravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory MyopathiesNo drug interventionstreatment2completed
NCT03840928
PatientSpot Formerly Known as ArthritisPowerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05361109
Baricitinib for Cutaneous Dermatomyositistreatment2withdrawn
NCT00335985
Efficacy and Safety Study of GB-0998 for Treatment of Steroid-resistant Polymyositis and Dermatomyositis (PM/DM)treatment3completed
NCT03293615
Exercise Capacity of Patients With DermatomyosisNo drug interventionspreventionNot Availablerecruiting
NCT02728752
Study Evaluating Efficacy and Safety of Octagam 10% in Patients With Dermatomyositis (Idiopathic Inflammatory Myopathy)treatment3completed
NCT03324152
Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and DermatomyositisNo drug interventionstreatmentNot Availableunknown_status
NCT05192200
An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Studytreatment2completed
NCT03582800
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot StudyNo drug interventionstreatment2recruiting
NCT06433999
A 12-Week Open-Label Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Skin-Predominant DermatomyositisNo drug interventionstreatment2not_yet_recruiting
NCT03002649
Study of Tofacitinib in Refractory Dermatomyositistreatment1completed
NCT01415219
Efficacy of an Individual Rehabilitation Program in Polymyositis and DermatomyositisNo drug interventionstreatment2completed
NCT02245841
Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositistreatment4completed
NCT05979441
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory MyopathyNo drug interventionstreatment3enrolling_by_invitation
NCT03817424
A Study to Evaluate VIB7734 in Participants With Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE), Sjogren's Syndrome, Systemic Sclerosis, Polymyositis, and Dermatomyositistreatment1completed
NCT00010335
Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune DisordersNo drug interventionstreatment1completed
NCT03414086
Predictor of Clinical Response to Acthar in MyositisNo drug interventionsNot AvailableNot Availablecompleted
NCT04402086
Rheumatology Patient Registry and BiorepositoryNo drug interventionsNot AvailableNot Availablerecruiting
NCT00504348
Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimustreatment2 / 3completed
NCT02612857
Trial of IMO-8400 in Adult Patients With Dermatomyositistreatment2completed
NCT03192657
Basiliximab Treating Interstitial Pneumonia of CADMtreatment2unknown_status
NCT04033926
A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositistreatment2completed
NCT00001265
Study and Treatment of Inflammatory Muscle DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT02271165
Subcutaneous Immunoglobulin (Hizentra) in Patients With Dermatomyositis: A Proof of Concept Studytreatment0terminated
NCT04999020
Ravulizumab Versus Placebo in Adult Participants With Dermatomyositistreatment2 / 3terminated
NCT05637931
Plexin D1 as a Potential Biomarker inPM/DMNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00001331
Genetic and Family Studies of Inherited Muscle DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT02880527
Study of the Prevalence of Polymyositis and Dermatomyositis in NormandyNo drug interventionsNot AvailableNot Availablecompleted
NCT05488327
Lenalidomide in the Treatment of Refractory Cutaneous DermatomyositistreatmentNot Availableunknown_status
NCT00033891
Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositistreatment2completed
NCT00213629
myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory MyopathiesNo drug interventionsdiagnosticNot Availablecompleted
NCT00651040
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DMtreatment3completed
NCT05523167
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants with Active Idiopathic Inflammatory Myopathy.No drug interventionstreatment2 / 3recruiting
NCT05650567
Study of M5049 in DM and PM Participants (NEPTUNIA)treatment2recruiting
NCT01906372
Acthar in Treatment of Refractory Dermatomyositis and Polymyositistreatment2completed
NCT04946669
An Exploratory Study on the Efficacy and Safety of Abatacept in the Treatment of Refractory Dermatomyositistreatment0unknown_status
NCT03686969
Study Evaluating Efficacy and Safety of Octanorm in Patients With Dermatomyositistreatment3terminated
NCT01148810
Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositistreatment2terminated
NCT00017914
Adult and Juvenile MyositisNo drug interventionsNot AvailableNot Availablerecruiting
NCT06002750
Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With InflammationNo drug interventionsNot AvailableNot Availablecompleted
NCT01315938
Abatacept Treatment in Polymyositis and Dermatomyositistreatment2completed