Hydroxylamines

Name
Hydroxylamines
Accession Number
DBCAT000393
Description

Organic compounds that contain the (-NH2OH) radical.

Drugs
DrugDrug Description
FluvoxamineA selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
Acetohydroxamic acidA synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.
PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
MarimastatFor the treatment of various cancers
SC-74020Not Available
CoprogenNot Available
Benzhydroxamic AcidNot Available
Indirubin-3'-monoximeNot Available
WAY-151693Not Available
Aminooxyacetic acidA compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
VorinostatA histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies.
FilaminastFilaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
GallichromeNot Available
XylarohydroxamateNot Available
Bb-3497Not Available
4-Phospho-D-erythronohydroxamic acidNot Available
BrasofensineFor the treatment of Parkinson's Disease.
BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
LX-2931Investigated for use/treatment in rheumatoid arthritis, inflammatory disorders (unspecified), and autoimmune diseases.
DarapladibInvestigated for use/treatment in atherosclerosis.
PanobinostatA non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
AsoprisnilInvestigated for use/treatment in uterine fibroids.
NorelgestrominA progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
AdrafinilUsed to relieve excessive sleepiness and inattention in elderly patients.
IbuproxamIbuproxam is a non steroidal anti-inflammatory drug (NSAID).
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
TosedostatTosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the...
LanopepdenLanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial.
CUDC-101CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others.
CG-200745Cg200745 has been used in trials studying the treatment of Solid Tumour.
RicolinostatRicolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer.
R-306465R306465 has been used in trials studying the treatment of Neoplasms.
ResminostatResminostat has been used in trials studying the treatment of Sezary Syndrome, Mycosis fungoides, Hodgkin's Lymphoma, Hepatocellular Carcinoma, and Lymphoma, T-Cell, Cutaneous, among others.
AbexinostatAbexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase...
PyroxamidePyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.
DidoxDidox has been used in trials studying the supportive care of Gastric Cancer.
QuisinostatQuisinostat has been used in trials studying the treatment of Lymphoma, Neoplasms, Myelodysplastic Syndromes, and Advanced or Refractory Leukemia.
BufexamacAn NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses.
ObidoximeNot Annotated
CTS-1027CTS-1027 has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C Virus Infection.
Glutamine hydroxamateNot Available
MartinostatMartinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).
TefinostatTefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)).
EpacadostatEpacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others.
ReposalReposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia.
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideNot Available
6-bromoindirubin-3'-oximeNot Available
Trichostatin ANot Available
CGS-27023Not Available
IlomastatNot Available
Drugs & Drug Targets
DrugTargetType
FluvoxamineSodium-dependent serotonin transportertarget
FluvoxamineCytochrome P450 1A2enzyme
FluvoxamineCytochrome P450 2D6enzyme
FluvoxamineCytochrome P450 2C9enzyme
FluvoxamineCytochrome P450 2C19enzyme
FluvoxamineCytochrome P450 1A1enzyme
FluvoxamineCytochrome P450 3A4enzyme
FluvoxamineCytochrome P450 3A Subfamilyenzyme
FluvoxamineP-glycoprotein 1transporter
FluvoxamineCytochrome P450 2B6enzyme
FluvoxaminePotassium voltage-gated channel subfamily H member 2target
FluvoxamineBile salt export pumptransporter
Acetohydroxamic acidUrease subunit alphatarget
Acetohydroxamic acidMacrophage metalloelastasetarget
PralidoximeAcetylcholinesterasetarget
PralidoximeCholinesterasetarget
DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DeferoxamineIrontarget
DeferoxamineAluminumtarget
DeferoxamineAmyloid beta A4 proteintarget
Marimastat72 kDa type IV collagenasetarget
MarimastatMatrix metalloproteinase-9target
MarimastatStromelysin-1target
MarimastatInterstitial collagenasetarget
MarimastatStromelysin-2target
MarimastatMatrilysintarget
MarimastatNeutrophil collagenasetarget
MarimastatStromelysin-3target
MarimastatMacrophage metalloelastasetarget
MarimastatCollagenase 3target
MarimastatMatrix metalloproteinase-14target
MarimastatMatrix metalloproteinase-15target
MarimastatMatrix metalloproteinase-16target
MarimastatMatrix metalloproteinase-17target
MarimastatMatrix metalloproteinase-19target
MarimastatMatrix metalloproteinase-20target
MarimastatMatrix metalloproteinase-21target
MarimastatMatrix metalloproteinase-23target
MarimastatMatrix metalloproteinase-24target
MarimastatMatrix metalloproteinase-25target
MarimastatMatrix metalloproteinase-26target
MarimastatMatrix metalloproteinase-27target
MarimastatMatrix metalloproteinase-28target
SC-7402072 kDa type IV collagenasetarget
CoprogenIron(3+)-hydroxamate-binding protein FhuDtarget
Indirubin-3'-monoximeGlycogen synthase kinase-3 betatarget
Indirubin-3'-monoximeCyclin-dependent kinase 5target
Indirubin-3'-monoximeCyclin-dependent kinase 1target
Indirubin-3'-monoximeCyclin-dependent kinase 5 activator 1target
Indirubin-3'-monoximeCyclin-dependent kinase 2target
Indirubin-3'-monoximeAryl hydrocarbon receptortarget
WAY-151693Collagenase 3target
Aminooxyacetic acidSerine--pyruvate aminotransferasetarget
VorinostatHistone deacetylase 1target
VorinostatHistone deacetylase 2target
VorinostatHistone deacetylase 3target
VorinostatHistone deacetylase 6target
VorinostatHistone deacetylase 8target
VorinostatAcetoin utilization proteintarget
FilaminastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
XylarohydroxamateGlucarate dehydratasetarget
Bb-3497Peptide deformylasetarget
Bb-3497Peptide deformylase, mitochondrialtarget
4-Phospho-D-erythronohydroxamic acidRibose-5-phosphate isomerase Btarget
BrasofensineDopamine D2 receptortarget
BelinostatHistone deacetylasetarget
BelinostatCytochrome P450 1A2enzyme
BelinostatUDP-glucuronosyltransferase 1-4enzyme
BelinostatCytochrome P450 2C8enzyme
BelinostatCytochrome P450 2C9enzyme
BelinostatP-glycoprotein 1transporter
BelinostatCytochrome P450 3A4enzyme
DarapladibCytosolic phospholipase A2target
PanobinostatCytochrome P450 2D6enzyme
PanobinostatCytochrome P450 3A4enzyme
PanobinostatP-glycoprotein 1transporter
PanobinostatHistone deacetylasetarget
AsoprisnilProgesterone receptortarget
NorelgestrominSteryl-sulfataseenzyme
NorelgestrominProgesterone receptortarget
NorelgestrominSerum albumintarget
NorelgestrominAndrogen receptortarget
NorelgestrominCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 2C8enzyme
DabrafenibP-glycoprotein 1transporter
DabrafenibATP-binding cassette sub-family G member 2transporter
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibSolute carrier family 22 member 8transporter
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibLIM domain kinase 1target
DabrafenibCytochrome P450 2B6enzyme
DabrafenibCytochrome P450 2C9enzyme
TosedostatPuromycin-sensitive aminopeptidasetarget
TosedostatLeukotriene A-4 hydrolasetarget
AbexinostatHistone deacetylase 1target
BufexamacProstaglandin G/H synthase 1target
BufexamacProstaglandin G/H synthase 2target
BufexamacHistone deacetylase 6target
BufexamacHistone deacetylase 10target
CTS-1027Collagenase 3target
Glutamine hydroxamateGlutamine--fructose-6-phosphate aminotransferase [isomerizing]target
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideHistone deacetylase 8target
6-bromoindirubin-3'-oximeGlycogen synthase kinase-3 betatarget
Trichostatin AHistone deacetylase 8target
Trichostatin AAcetoin utilization proteintarget
Trichostatin AHistone deacetylase 7target
CGS-27023Macrophage metalloelastasetarget
CGS-27023Interstitial collagenasetarget
IlomastatLethal factortarget
IlomastatDisintegrin and metalloproteinase domain-containing protein 28target
IlomastatAggrecan core proteintarget