Hydroxylamines

Name
Hydroxylamines
Accession Number
DBCAT000393
Description

Organic compounds that contain the (-NH2OH) radical.

Drugs
DrugDrug Description
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideNot Available
4-Phospho-D-erythronohydroxamic acidNot Available
6-bromoindirubin-3'-oximeNot Available
AbexinostatAbexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase...
Acetohydroxamic acidA synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.
AdrafinilUsed to relieve excessive sleepiness and inattention in elderly patients.
AlilusemAlilusem is a small molecule drug. Alilusem has a monoisotopic molecular weight of 394.04 Da.
Aminooxyacetic acidA compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
AncrivirocAncriviroc is a small molecule drug. The usage of the INN stem '-viroc' in the name indicates that Ancriviroc is a CCR5 (Chemokine CC motif receptor 5) receptor antagonist. Ancriviroc...
AsoprisnilInvestigated for use/treatment in uterine fibroids.
Bb-3497Not Available
BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
BeloxamideBeloxamide is a small molecule drug. Beloxamide has a monoisotopic molecular weight of 283.16 Da.
BenurestatBenurestat is a small molecule drug. The usage of the INN stem '-restat' in the name indicates that Benurestat is a aldose reductase inhibitor. Benurestat has a monoisotopic molecular weight...
Benzhydroxamic AcidNot Available
BrasofensineFor the treatment of Parkinson's Disease.
BufexamacAn NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses.
Caprylhydroxamic acidNot Annotated
CGS-27023Not Available
ClovoxamineClovoxamine is a small molecule drug. Clovoxamine has a monoisotopic molecular weight of 284.13 Da.
CoprogenNot Available
CTS-1027CTS-1027 has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C Virus Infection.
CUDC-101CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others.
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DacinostatDacinostat is a novel histone deacetylase inhibitor.
DarapladibInvestigated for use/treatment in atherosclerosis.
DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
DiclofurimeDiclofurime is a small molecule drug. Diclofurime has a monoisotopic molecular weight of 384.1 Da.
DidoxDidox has been used in trials studying the supportive care of Gastric Cancer.
EnviroximeEnviroxime is a small molecule drug. Enviroxime has a monoisotopic molecular weight of 358.11 Da.
EpacadostatEpacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others.
FilaminastFilaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
FluvoxamineA selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
GallichromeNot Available
GivinostatA histone deacetylase inhibitor indicated for the treatment of Duchenne Muscular Dystrophy (DMD).
GlucoraphaninGlucoraphanin is under investigation in clinical trial NCT01879878 (Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]).
Glutamine hydroxamateNot Available
GSK2256098GSK2256098 is under investigation in clinical trial NCT02523014 (Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas).
IbuproxamIbuproxam is a non steroidal anti-inflammatory drug (NSAID).
IlomastatIlomastat is a broad-spectrum matrix metalloproteinase inhibitor.
Indirubin-3'-monoximeNot Available
IvaltinostatNot Annotated
LanopepdenLanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial.
LX-2931Investigated for use/treatment in rheumatoid arthritis, inflammatory disorders (unspecified), and autoimmune diseases.
MarimastatFor the treatment of various cancers
MartinostatMartinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).
MilamelineMilameline is a small molecule drug. Milameline has a monoisotopic molecular weight of 154.11 Da.
NolasibanNolasiban is under investigation in clinical trial NCT03081208 (Phase 3 Placebo Controlled Study of Nolasiban to Improve Pregnancy Rates in Women Undergoing IVF/ICSI).
NorelgestrominA progestin used as the progestational component of a transdermal combined hormonal contraceptive, preventing pregnancy primarily through suppression of ovulation.
NP-51Not Annotated
ObidoximeNot Annotated
PanobinostatA non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
PG-530742Investigated for use/treatment in osteoarthritis.
PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
PyroxamidePyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.
QuisinostatQuisinostat has been used in trials studying the treatment of Lymphoma, Neoplasms, Myelodysplastic Syndromes, and Advanced or Refractory Leukemia.
R-306465R306465 has been used in trials studying the treatment of Neoplasms.
ReposalReposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia.
ResminostatResminostat has been used in trials studying the treatment of Sezary Syndrome, Mycosis fungoides, Hodgkin's Lymphoma, Hepatocellular Carcinoma, and Lymphoma, T-Cell, Cutaneous, among others.
RicolinostatRicolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer.
SC-74020Not Available
SibrafibanSibrafiban is a small molecule drug. The usage of the INN stem '-fiban' in the name indicates that Sibrafiban is a fibrinogen receptor antagonist (glycoprotein IIb/IIIa receptor antagonist). Sibrafiban has...
SolimastatSolimastat is a small molecule drug. The usage of the INN stem '-mastat' in the name indicates that Solimastat is a matrix metalloproteinase inhibitor. Solimastat has a monoisotopic molecular weight...
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
TefinostatTefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)).
TosedostatTosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the...
Trichostatin ANot Available
TRO40303TRO40303 is under investigation in clinical trial NCT01374321 (Safety and Efficacy Study of TRO40303 for Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction).
UpamostatUpamostat has been used in trials studying the treatment of Pancreatic Cancer.
VorinostatA histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies.
WAY-151693Not Available
XylarohydroxamateNot Available
ZinviroximeZinviroxime is a small molecule drug. Zinviroxime has a monoisotopic molecular weight of 358.11 Da.
Drugs & Drug Targets
DrugTargetType
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideDopamine receptor D3target
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideDopamine receptor D2target
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideHistone deacetylase 8target
4-Phospho-D-erythronohydroxamic acidRibose-5-phosphate isomerase Btarget
6-bromoindirubin-3'-oximeAurora kinase Ctarget
6-bromoindirubin-3'-oximeAurora kinase Atarget
6-bromoindirubin-3'-oximeAurora kinase Btarget
6-bromoindirubin-3'-oximeGlycogen synthase kinase-3 alphatarget
6-bromoindirubin-3'-oximeGlycogen synthase kinase-3 betatarget
AbexinostatHistone deacetylasetarget
AbexinostatHistone deacetylase 1target
Acetohydroxamic acidMacrophage metalloelastasetarget
Acetohydroxamic acidUrease subunit alphatarget
AdrafinilAlpha adrenergic receptortarget
AdrafinilAlpha-1 adrenergic receptorstarget
Aminooxyacetic acidAlanine--glyoxylate aminotransferasetarget
Aminooxyacetic acidCystathionine beta-synthasetarget
AncrivirocC-C chemokine receptor type 5target
AsoprisnilProgesterone receptortarget
Bb-3497Peptide deformylasetarget
Bb-3497Peptide deformylase, mitochondrialtarget
Bb-3497Peptide deformylasetarget
BelinostatHistone deacetylasetarget
BelinostatCytochrome P450 3A4enzyme
BelinostatATP-dependent translocase ABCB1transporter
BelinostatCytochrome P450 2C9enzyme
BelinostatCytochrome P450 1A2enzyme
BelinostatUDP-glucuronosyltransferase 1A1enzyme
BelinostatCytochrome P450 2C8enzyme
BrasofensineDopamine receptor D2target
BrasofensineSodium-dependent serotonin transportertarget
BufexamacPolyamine deacetylase HDAC10target
BufexamacProtein deacetylase HDAC6target
BufexamacProstaglandin G/H synthase 2target
BufexamacProstaglandin G/H synthase 1target
CGS-27023Matrix metalloproteinase-9target
CGS-27023Lethal factortarget
CGS-27023Macrophage metalloelastasetarget
CGS-27023Interstitial collagenasetarget
CGS-27023Neutrophil collagenasetarget
CGS-27023Carbonic anhydrase 9target
CGS-27023Matrilysintarget
CGS-27023A disintegrin and metalloproteinase with thrombospondin motifs 4target
CGS-2702372 kDa type IV collagenasetarget
CGS-27023Matrix metalloproteinase-14target
CGS-27023Stromelysin-1target
CGS-27023Carbonic anhydrase 2target
CGS-27023Collagenase 3target
ClovoxamineSodium-dependent noradrenaline transportertarget
ClovoxamineSodium-dependent serotonin transportertarget
CoprogenIron(3+)-hydroxamate-binding protein FhuDtarget
CTS-1027Macrophage metalloelastasetarget
CTS-1027Neutrophil collagenasetarget
CTS-1027Matrix metalloproteinase-14target
CTS-1027Interstitial collagenasetarget
CTS-1027Matrix metalloproteinase-9target
CTS-102772 kDa type IV collagenasetarget
CTS-1027Stromelysin-1target
CTS-1027Collagenase 3target
CUDC-101Histone deacetylasetarget
CUDC-101Receptor tyrosine-protein kinase erbB-2target
CUDC-101Epidermal growth factor receptortarget
DabrafenibCytochrome P450 1A2enzyme
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DabrafenibAlbumincarrier
DabrafenibATP-dependent translocase ABCB1transporter
DabrafenibCytochrome P450 2C8enzyme
DabrafenibCytochrome P450 2C19enzyme
DabrafenibCytochrome P450 2C9enzyme
DabrafenibCytochrome P450 2B6enzyme
DabrafenibLIM domain kinase 1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibSolute carrier organic anion transporter family member 1A2transporter
DabrafenibSolute carrier family 22 member 2transporter
DabrafenibOrganic anion transporter 3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibCytochrome P450 3A4enzyme
DabrafenibUDP-glucuronosyltransferase 1A1enzyme
DacinostatHistone deacetylase 1target
DarapladibCytosolic phospholipase A2target
DarapladibPhospholipase A2target
DarapladibPlatelet-activating factor acetylhydrolasetarget
DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DeferoxamineIrontarget
DeferoxamineAluminumtarget
DeferoxamineAmyloid-beta precursor proteintarget
DidoxRibonucleoside-diphosphate reductase subunit M2 Btarget
DidoxRibonucleoside-diphosphate reductase subunit M2target
DidoxRibonucleoside-diphosphate reductase large subunittarget
EnviroximePhosphatidylinositol 4-kinase betatarget
EnviroximePhosphatidylinositol 3-kinasetarget
EpacadostatIndoleamine 2,3-dioxygenase 1target
Filaminast3',5'-cyclic-AMP phosphodiesterase 4Btarget
FluvoxamineSodium-dependent serotonin transportertarget
FluvoxamineCytochrome P450 2B6enzyme
FluvoxamineCytochrome P450 1A2enzyme
FluvoxamineCytochrome P450 2D6enzyme
FluvoxamineCytochrome P450 2C9enzyme
FluvoxamineCytochrome P450 2C19enzyme
FluvoxamineCytochrome P450 1A1enzyme
FluvoxamineATP-dependent translocase ABCB1transporter
FluvoxamineCytochrome P450 3A Subfamilyenzyme
FluvoxamineVoltage-gated inwardly rectifying potassium channel KCNH2target
FluvoxamineBile salt export pumptransporter
FluvoxamineCytochrome P450 3A4enzyme
GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
GivinostatTyrosine-protein kinase JAK2target
GivinostatHistone deacetylase 1target
GivinostatCytochrome P450 2B6enzyme
GivinostatCytochrome P450 1A2enzyme
GivinostatSolute carrier family 22 member 2transporter
GivinostatCytochrome P450 3A4enzyme
GivinostatHistone deacetylasetarget
GlucoraphaninNuclear factor erythroid 2-related factor 2target
Glutamine hydroxamateGlutamine--fructose-6-phosphate aminotransferase [isomerizing]target
GSK2256098Focal adhesion kinase 1target
IbuproxamC-X-C chemokine receptor type 2target
IbuproxamC-X-C chemokine receptor type 1target
IbuproxamPolyunsaturated fatty acid 5-lipoxygenasetarget
IlomastatDisintegrin and metalloproteinase domain-containing protein 28target
IlomastatAggrecan core proteintarget
IlomastatInterstitial collagenasetarget
IlomastatMatrix metalloproteinase-14target
IlomastatNeutrophil collagenasetarget
IlomastatLethal factortarget
IlomastatStromelysin-1target
IlomastatMatrix metalloproteinase-9target
IlomastatMacrophage metalloelastasetarget
IlomastatCollagenase 3target
Ilomastat72 kDa type IV collagenasetarget
Indirubin-3'-monoximeAurora kinase Btarget
Indirubin-3'-monoximeAurora kinase Atarget
Indirubin-3'-monoximeAryl hydrocarbon receptortarget
Indirubin-3'-monoximeAurora kinase Ctarget
Indirubin-3'-monoximeCyclin-dependent kinase 5target
Indirubin-3'-monoximeGlycogen synthase kinase-3 betatarget
Indirubin-3'-monoximeCyclin-dependent kinase 2target
Indirubin-3'-monoximeCyclin-dependent kinase 5 activator 1target
Indirubin-3'-monoximeCyclin-dependent kinase 1target
IvaltinostatHistone deacetylasetarget
LanopepdenPeptide deformylasetarget
LX-2931Sphingosine-1-phosphate lyase 1target
MarimastatMatrilysintarget
MarimastatMacrophage metalloelastasetarget
MarimastatMatrix metalloproteinase-28target
MarimastatMatrix metalloproteinase-27target
MarimastatMatrix metalloproteinase-26target
MarimastatMatrix metalloproteinase-25target
MarimastatMatrix metalloproteinase-24target
MarimastatMatrix metalloproteinase-23target
MarimastatMatrix metalloproteinase-21target
MarimastatMatrix metalloproteinase-20target
MarimastatMatrix metalloproteinase-19target
MarimastatMatrix metalloproteinase-17target
MarimastatMatrix metalloproteinase-16target
MarimastatMatrix metalloproteinase-15target
MarimastatMatrix metalloproteinase-14target
MarimastatCollagenase 3target
MarimastatMatrix metalloproteinase-9target
MarimastatStromelysin-3target
MarimastatNeutrophil collagenasetarget
MarimastatStromelysin-1target
MarimastatInterstitial collagenasetarget
MarimastatStromelysin-2target
Marimastat72 kDa type IV collagenasetarget
MartinostatHistone deacetylase 3target
MartinostatHistone deacetylase 1target
MartinostatHistone deacetylase 2target
MartinostatProtein deacetylase HDAC6target
MartinostatHistone deacetylase 5target
MartinostatHistone deacetylase 4target
MartinostatHistone deacetylase 7target
MartinostatHistone deacetylase 8target
MartinostatHistone deacetylase 9target
MilamelineMuscarinic acetylcholine receptortarget
MilamelineMuscarinic acetylcholine receptor M1target
MilamelineMuscarinic acetylcholine receptor M2target
MilamelineMuscarinic acetylcholine receptor M5target
MilamelineMuscarinic acetylcholine receptor M4target
MilamelineMuscarinic acetylcholine receptor M3target
NolasibanOxytocin receptortarget
NorelgestrominSteryl-sulfataseenzyme
NorelgestrominProgesterone receptortarget
NorelgestrominAlbumintarget
NorelgestrominAndrogen receptortarget
NorelgestrominCytochrome P450 3A4enzyme
NP-51Mitogen-activated protein kinase 10target
NP-51Mitogen-activated protein kinase 8target
NP-51Mitogen-activated protein kinase 9target
ObidoximeAcetylcholinesterasetarget
PanobinostatCytochrome P450 2D6enzyme
PanobinostatCytochrome P450 3A4enzyme
PanobinostatATP-dependent translocase ABCB1transporter
PanobinostatHistone deacetylasetarget
PanobinostatHistone deacetylase 1target
PG-530742Matrix metalloproteinase-9target
PG-530742Stromelysin-1target
PralidoximeAcetylcholinesterasetarget
PralidoximeCholinesterasetarget
PyroxamideHistone deacetylase 1target
PyroxamideHistone deacetylasetarget
QuisinostatHistone deacetylasetarget
R-306465Histone deacetylase 8target
R-306465Histone deacetylase 1target
R-306465Histone deacetylasetarget
ReposalProtein deacetylase HDAC6target
ResminostatHistone deacetylase 1target
RicolinostatProtein deacetylase HDAC6target
SC-7402072 kDa type IV collagenasetarget
SibrafibanIntegrin alpha-IIbtarget
SibrafibanIntegrin beta-3target
SolimastatMatrilysintarget
Solimastat72 kDa type IV collagenasetarget
SolimastatInterstitial collagenasetarget
TefinostatLiver carboxylesterase 1enzyme
TefinostatHistone deacetylasetarget
TosedostatLeukotriene A-4 hydrolasetarget
TosedostatPuromycin-sensitive aminopeptidasetarget
Trichostatin ATumor necrosis factortarget
Trichostatin AProstaglandin E2 Receptorstarget
Trichostatin ACaspase-8target
Trichostatin AHistone deacetylase 7target
Trichostatin ANAD-independent protein lysine deacetylasetarget
Trichostatin AHistone deacetylase 8target
TRO40303Translocator proteintarget
UpamostatUrokinase-type plasminogen activatortarget
VorinostatHistone deacetylasetarget
VorinostatHistone deacetylase 1target
VorinostatHistone deacetylase 2target
VorinostatHistone deacetylase 3target
VorinostatProtein deacetylase HDAC6target
VorinostatHistone deacetylase 8target
WAY-151693Collagenase 3target
XylarohydroxamateGlucarate dehydratasetarget