Refractory Acute Myelogenous Leukemia (AML)

Also known as: Acute Myeloid Leukemia Refractory / Acute, refractory Myeloid Leukemia / Refractory Acute Myeloid Leukemia / Acute Myeloid Leukemia, Refractory / Refractory AML / Refractory Acute Myeloid Leukemia (AML) / Refractory Acute Myelogenous Leukemia / Acute, refractory Myelogenous Leukemia / Refractory acute myeloid leukemia (disorder) / Acute myeloid leukaemia refractory

DrugDrug NameDrug Description
DB00631ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
DB13874EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
DB00056Gemtuzumab ozogamicinA monoclonal anti-CD33 antibody used to treat CD33-positive acute myeloid leukemia.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibCytochrome P450 1A2enzyme
DB13874EnasidenibCytochrome P450 2B6enzyme
DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB13874EnasidenibCytochrome P450 2C8enzyme
DB13874EnasidenibCytochrome P450 2C9enzyme
DB13874EnasidenibCytochrome P450 2C19enzyme
DB13874EnasidenibCytochrome P450 2D6enzyme
DB13874EnasidenibCytochrome P450 3A4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-1enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-3enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-9enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B7enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B15enzyme
DB13874EnasidenibP-glycoprotein 1transporter
DB13874EnasidenibATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibSolute carrier family 22 member 6transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B1transporter
DB13874EnasidenibSolute carrier family 22 member 2transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B3transporter
DB13874EnasidenibSolute carrier family 22 member 8transporter
DB00056Gemtuzumab ozogamicinMyeloid cell surface antigen CD33target
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00056Gemtuzumab ozogamicinHigh affinity immunoglobulin gamma Fc receptor Itarget
DrugDrug NamePhaseStatusCount
DB09037Pembrolizumab0Withdrawn1
DB12001Abemaciclib1Recruiting1
DB05812Abiraterone1Recruiting1
DB08916Afatinib1Recruiting1
DB00062Albumin human1Recruiting1
DB09495Avobenzone1Recruiting1
DB00928Azacitidine1Active Not Recruiting1
DB00928Azacitidine1Completed1
DB00928Azacitidine1Recruiting1
DB05015Belinostat1Recruiting1
DB05015Belinostat1Terminated1
DB00112Bevacizumab1Recruiting1
DB01128Bicalutamide1Recruiting1
DB00188Bortezomib1Recruiting1
DB06772Cabazitaxel1Recruiting1
DB08875Cabozantinib1Completed1
DB08875Cabozantinib1Recruiting1
DB01101Capecitabine1Recruiting1
DB00958Carboplatin1Recruiting1
DB00482Celecoxib1Recruiting1
DB00242Cladribine1Not Yet Recruiting1
DB00242Cladribine1Recruiting2
DB05239Cobimetinib1Recruiting1
DB12483Copanlisib1Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting4
DB00091Cyclosporine1Recruiting1
DB00987Cytarabine1Active Not Recruiting3
DB00987Cytarabine1Completed4
DB00987Cytarabine1Not Yet Recruiting2
DB00987Cytarabine1Recruiting7
DB00987Cytarabine1Suspended1
DB00987Cytarabine1Terminated1
DB08912Dabrafenib1Recruiting1
DB11963Dacomitinib1Recruiting1
DB12941Darolutamide1Recruiting1
DB01254Dasatinib1Recruiting1
DB00694Daunorubicin1Recruiting2
DB01262Decitabine1Active Not Recruiting1
DB01262Decitabine1Completed1
DB01262Decitabine1Recruiting6
DB01262Decitabine1Withdrawn1
DB01234Dexamethasone1Recruiting1
DB00997Doxorubicin1Recruiting1
DB11714Durvalumab1Recruiting1
DB14598Edetate calcium disodium anhydrous1Recruiting1
DB00974Edetic acid1Recruiting1
DB13874Enasidenib1Recruiting1
DB11986Entrectinib1Recruiting1
DB08899Enzalutamide1Recruiting1
DB00530Erlotinib1Recruiting1
DB00773Etoposide1Completed2
DB00773Etoposide1Suspended1
DB01590Everolimus1Recruiting1
DB11680Ficlatuzumab1Terminated1
DB00099Filgrastim1Completed1
DB00099Filgrastim1Not Yet Recruiting2
DB00099Filgrastim1Recruiting3
DB15223Flotetuzumab1Active Not Recruiting1
DB01073Fludarabine1Active Not Recruiting3
DB01073Fludarabine1Completed1
DB01073Fludarabine1Not Yet Recruiting1
DB01073Fludarabine1Recruiting5
DB00544Fluorouracil1Recruiting1
DB00056Gemtuzumab ozogamicin1Recruiting1
DB14999Human interferon beta1Recruiting1
DB00741Hydrocortisone1Active Not Recruiting1
DB00741Hydrocortisone1Recruiting1
DB14539Hydrocortisone acetate1Active Not Recruiting1
DB09054Idelalisib1Recruiting1
DB00619Imatinib1Recruiting1
DB06186Ipilimumab1Recruiting3
DB14568Ivosidenib1Not Yet Recruiting1
DB09570Ixazomib1Completed1
DB09078Lenvatinib1Recruiting1
DB00650Leucovorin1Recruiting1
DB12130Lorlatinib1Recruiting1
DB00678Losartan1Recruiting1
DB11740MK-17751Terminated1
DB16620Methopterin1Active Not Recruiting1
DB00563Methotrexate1Active Not Recruiting1
DB00563Methotrexate1Recruiting1
DB01204Mitoxantrone1Completed2
DB01204Mitoxantrone1Not Yet Recruiting1
DB01204Mitoxantrone1Recruiting2
DB01204Mitoxantrone1Suspended1
DB00688Mycophenolate mofetil1Recruiting1
DB01024Mycophenolic acid1Recruiting1
DB15721Natural Killer Cell1Completed1
DB15721Natural Killer Cell1Recruiting1
DB15299Navtemadlin1Recruiting1
DB16252Nedisertib1Suspended1
DB11828Neratinib1Recruiting1
DB09079Nintedanib1Recruiting1
DB09035Nivolumab1Recruiting2
DB16630OPB-1110771Recruiting1
DB09496Octinoxate1Recruiting1
DB09074Olaparib1Recruiting1
DB00526Oxaliplatin1Recruiting1
DB01229Paclitaxel1Recruiting1
DB09073Palbociclib1Recruiting2
DB06603Panobinostat1Recruiting1
DB16281Pegcrisantaspase1Recruiting1
DB09037Pembrolizumab1Recruiting2
DB06366Pertuzumab1Recruiting1
DB11759Pevonedistat1Active Not Recruiting2
DB11759Pevonedistat1Recruiting1
DB08901Ponatinib1Recruiting1
DB12008Prexasertib1Active Not Recruiting1
DB05213Quizartinib1Completed1
DB08896Regorafenib1Recruiting1
DB08877Ruxolitinib1Recruiting3
DB14797SEphB4-HSA1Recruiting1
DB11942Selinexor1Active Not Recruiting1
DB11942Selinexor1Recruiting1
DB00877Sirolimus1Recruiting1
DB11119Sodium iodide1Recruiting1
DB00398Sorafenib1Recruiting2
DB00566Succimer1Recruiting1
DB01268Sunitinib1Recruiting1
DB15013TAK-2431Withdrawn1
DB08911Trametinib1Recruiting1
DB05773Trastuzumab emtansine1Recruiting1
DB00755Tretinoin1Recruiting1
DB00135Tyrosine1Recruiting1
DB08881Vemurafenib1Recruiting1
DB11581Venetoclax1Not Yet Recruiting1
DB11581Venetoclax1Recruiting4
DB00541Vincristine1Recruiting1
DB08828Vismodegib1Recruiting1
DB02546Vorinostat1Completed1
DB02546Vorinostat1Recruiting1
DB160758-Chloroadenosine1 / 2Suspended1
DB00640Adenosine1 / 2Suspended1
DB00041Aldesleukin1 / 2Recruiting1
DB03496Alvocidib1 / 2Withdrawn1
DB11945Avelumab1 / 2Recruiting1
DB11945Avelumab1 / 2Terminated1
DB00928Azacitidine1 / 2Completed1
DB00928Azacitidine1 / 2Recruiting6
DB00928Azacitidine1 / 2Terminated1
DB01008Busulfan1 / 2Recruiting1
DB15694Cedazuridine1 / 2Recruiting2
DB15694Cedazuridine1 / 2Withdrawn1
DB00242Cladribine1 / 2Completed1
DB09110Coenzyme M1 / 2Recruiting1
DB14681Cortisone1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting3
DB00091Cyclosporine1 / 2Recruiting1
DB00987Cytarabine1 / 2Completed1
DB00987Cytarabine1 / 2Recruiting6
DB00694Daunorubicin1 / 2Recruiting1
DB01262Decitabine1 / 2Completed2
DB01262Decitabine1 / 2Recruiting3
DB01262Decitabine1 / 2Withdrawn2
DB01234Dexamethasone1 / 2Recruiting1
DB13874Enasidenib1 / 2Recruiting1
DB00099Filgrastim1 / 2Completed1
DB00099Filgrastim1 / 2Recruiting4
DB01073Fludarabine1 / 2Recruiting4
DB00056Gemtuzumab ozogamicin1 / 2Recruiting2
DB12141Gilteritinib1 / 2Not Yet Recruiting1
DB12141Gilteritinib1 / 2Recruiting2
DB11978Glasdegib1 / 2Recruiting1
DB01177Idarubicin1 / 2Recruiting1
DB14568Ivosidenib1 / 2Recruiting2
DB16208Ivuxolimab1 / 2Recruiting1
DB14770Lanraplenib1 / 2Not Yet Recruiting1
DB00650Leucovorin1 / 2Recruiting1
DB16225Magrolimab1 / 2Recruiting1
DB16620Methopterin1 / 2Recruiting1
DB00563Methotrexate1 / 2Recruiting1
DB00723Methoxamine1 / 2Recruiting1
DB00959Methylprednisolone1 / 2Recruiting1
DB01204Mitoxantrone1 / 2Completed1
DB00688Mycophenolate mofetil1 / 2Recruiting3
DB15721Natural Killer Cell1 / 2Recruiting1
DB16267Olutasidenib1 / 2Withdrawn1
DB04865Omacetaxine mepesuccinate1 / 2Not Yet Recruiting1
DB00019Pegfilgrastim1 / 2Recruiting1
DB12920Pinometostat1 / 2Completed1
DB01263Posaconazole1 / 2Recruiting1
DB00635Prednisone1 / 2Recruiting1
DB12874Quizartinib1 / 2Recruiting3
DB00073Rituximab1 / 2Recruiting1
DB08877Ruxolitinib1 / 2Completed1
DB00877Sirolimus1 / 2Recruiting1
DB00398Sorafenib1 / 2Recruiting1
DB00864Tacrolimus1 / 2Recruiting2
DB11760Talazoparib1 / 2Recruiting1
DB11581Venetoclax1 / 2Not Yet Recruiting1
DB11581Venetoclax1 / 2Recruiting10
DB11581Venetoclax1 / 2Withdrawn1
DB00541Vincristine1 / 2Recruiting1
DB00582Voriconazole1 / 2Recruiting1
DB00437Allopurinol2Terminated1
DB00928Azacitidine2Active Not Recruiting1
DB00928Azacitidine2Recruiting4
DB00928Azacitidine2Terminated1
DB01008Busulfan2Terminated1
DB01008Busulfan2Withdrawn1
DB00958Carboplatin2Active Not Recruiting1
DB15694Cedazuridine2Not Yet Recruiting1
DB15694Cedazuridine2Recruiting1
DB00242Cladribine2Completed1
DB00242Cladribine2Recruiting2
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Not Yet Recruiting1
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Completed1
DB00091Cyclosporine2Withdrawn1
DB00987Cytarabine2Completed1
DB00987Cytarabine2Not Yet Recruiting2
DB00987Cytarabine2Recruiting5
DB09331Daratumumab2Recruiting1
DB01254Dasatinib2Terminated1
DB00694Daunorubicin2Not Yet Recruiting1
DB00694Daunorubicin2Recruiting4
DB01262Decitabine2Not Yet Recruiting1
DB01262Decitabine2Recruiting4
DB00590Doxazosin2Recruiting2
DB13874Enasidenib2Recruiting2
DB13874Enasidenib2Withdrawn1
DB00099Filgrastim2Completed1
DB00099Filgrastim2Not Yet Recruiting1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Completed1
DB01073Fludarabine2Not Yet Recruiting2
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Withdrawn1
DB00056Gemtuzumab ozogamicin2Recruiting1
DB12141Gilteritinib2Recruiting1
DB14865Human interleukin-22Not Yet Recruiting2
DB14865Human interleukin-22Terminated1
DB01177Idarubicin2Recruiting2
DB09054Idelalisib2Terminated1
DB06186Ipilimumab2Recruiting1
DB02325Isopropyl alcohol2Recruiting2
DB14568Ivosidenib2Recruiting1
DB12504JNJ-403465272Terminated1
DB01202Levetiracetam2Terminated1
DB11754Lirilumab2Terminated1
DB00888Mechlorethamine2Completed1
DB01042Melphalan2Completed1
DB16620Methopterin2Active Not Recruiting1
DB16620Methopterin2Withdrawn1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Withdrawn1
DB06595Midostaurin2Recruiting1
DB01204Mitoxantrone2Completed1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed1
DB15721Natural Killer Cell2Not Yet Recruiting1
DB09035Nivolumab2Recruiting1
DB09074Olaparib2Recruiting1
DB11697Pacritinib2Terminated1
DB11759Pevonedistat2Active Not Recruiting1
DB08901Ponatinib2Recruiting1
DB08901Ponatinib2Terminated1
DB12874Quizartinib2Recruiting1
DB08877Ruxolitinib2Terminated1
DB01399Salsalate2Recruiting1
DB00877Sirolimus2Completed1
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Withdrawn1
DB04572Thiotepa2Active Not Recruiting1
DB01030Topotecan2Active Not Recruiting1
DB08911Trametinib2Recruiting1
DB03754Tromethamine2Active Not Recruiting1
DB07232Veliparib2Active Not Recruiting1
DB11581Venetoclax2Not Yet Recruiting1
DB11581Venetoclax2Recruiting7