Monotherapy (DBCOND0049070)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aripiprazole	An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.	D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Etarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Histamine H1 receptortarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 5Atarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Histamine H2 receptortarget Histamine H3 receptortarget Histamine H4 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Kappa-type opioid receptortarget Mu-type opioid receptortarget Delta-type opioid receptortarget Glutamate (NMDA) receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent serotonin transportertarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Empagliflozin	An SGLT2 inhibitor used to manage type 2 diabetes mellitus.	Sodium/glucose cotransporter 2target UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Inotuzumab ozogamicin	An antibody-drug conjugate used to treat B-cell precursor acute lymphoblastic leukemia (ALL).	ATP-dependent translocase ABCB1transporter B-cell receptor CD22target
Irinotecan	A topoisomerase inhibitor used to treat metastatic carcinoma of the colon or rectum and pancreatic adenocarcinoma.	DNA topoisomerase I, mitochondrialtarget DNA topoisomerase 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 1B1transporter Multidrug resistance-associated protein 1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Human Carboxylesterasesenzyme
Natalizumab	A monoclonal anti-integrin antibody used to treat Crohn's disease or multiple sclerosis.	Integrin alpha-4target Low affinity immunoglobulin gamma Fc region receptor III-Btarget High affinity immunoglobulin gamma Fc receptor Itarget Intercellular adhesion molecule 1target
Oxcarbazepine	An anti-epileptic used in the treatment of partial-onset seizures.	Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Albumincarrier ATP-dependent translocase ABCB1transporter Aldo-keto reductase family 1 member C1enzyme Aldo-keto reductase family 1 member C2enzyme Aldo-keto reductase family 1 member C3enzyme Aldo-keto reductase family 1 member C4enzyme Carbonyl reductase [NADPH] 1enzyme Carbonyl reductase [NADPH] 3enzyme Sodium channel proteintarget Sodium channel protein type 11 subunit alphatarget
Pemetrexed	A folate analog used to treat mesothelioma and non-small cell lung cancer.	Thymidylate synthasetarget Dihydrofolate reductasetarget Trifunctional purine biosynthetic protein adenosine-3target Deoxycytidine kinaseenzyme Bifunctional purine biosynthesis protein ATICtarget Equilibrative nucleoside transporter 1enzyme Organic anion transporter 3transporter Reduced folate transportertransporter Proton-coupled folate transportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 5transporter Solute carrier family 22 member 6transporter Albumincarrier Solute carrier family 22 member 11transporter Thymidylate synthasetarget
Spesolimab	An interleukin-36 receptor antagonist used to treat generalized pustular psoriasis flares in adults.	Interleukin-1 receptor-like 2target
Tisotumab vedotin	A tissue factor-directed antibody drug conjugate that is used to treat adults with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.	Cytochrome P450 3A4enzyme Tissue factortarget ATP-dependent translocase ABCB1transporter
Tocilizumab	An interleukin-6 (IL-6) receptor antagonist used to treat Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA).	Interleukin-6 receptor subunit alphatarget Cytochrome P450 3A4enzyme
Vinorelbine	A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.	Tubulin beta chaintarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05958524	Analysis of Factors Influencing the Efficacy of Levamlodipine Benzoate and Its Population Pharmacodynamic Modeling	No drug interventions	Not Available	Not Available	recruiting
NCT06159166	Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).	Mirdametinib	treatment	1 / 2	recruiting
NCT02551523	Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection	Dolutegravir	treatment	2	unknown_status
NCT01243177	Trial Comparing the Efficacy and Safety of Lacosamide (LCM) to Carbamazepine Controlled-Release (CBZ-CR); Initial Monotherapy in Epilepsy; Subjects Aged 16 and Older	Carbamazepine Lacosamide	treatment	3	completed
NCT02572947	A Pilot Study of MONOtherapy of DOlutegravir in HIV-1 Virologically Suppressed Patients	Dolutegravir	treatment	2	completed
NCT01465997	Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older	Carbamazepine Lacosamide	treatment	3	completed