Myeloid Leukemia, Chronic, Chronic Phase

Also known as: Leukemia, Myeloid, Chronic-Phase (CML-CP) / Chronic Myeloid Leukemia in Chronic Phase / Chronic Phase of Chronic Myeloid Leukemia / Myeloid Leukemia, Chronic, Chronic-Phase / Leukemia, Myeloid, Chronic Phase / Chronic Phase-Chronic Myeloid Leukemia / Leukemia, Myeloid, Chronic-Phase / Chronic Myeloid Leukemia, Chronic Phase / Chronic Phase Chronic Myeloid Leukemia / Chronic Myeloid Leukemia - Chronic Phase / Leukemia, Myelogenous, Chronic Phase / Myelogenous Leukemia, Chronic, Chronic Phase / Chronic Myelogenous Leukemia - Chronic Phase / Chronic Phase Chronic Myelogenous Leukemia / Chronic phase chronic myeloid leukemia (disorder) / Chronic phase chronic myeloid leukaemia / Chronic myeloid leukemia (morphologic abnormality) / Myeloid leukemia, chronic / Chronic myeloid leukemia, disease (disorder) / Chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality) / Chronic myeloid leukaemia / Chronic myeloid leukemia / CML / Chronic myelogenous leukaemia / Chronic myelocytic leukaemia / Leukemia myelocytic chronic / Chronic myelogenous leukemia / Leukaemia myelocytic chronic / Chronic granulocytic leukemia / Leukaemias chronic myeloid / Chronic myelocytic leukemia / Chronic granulocytic leukaemia / Myeloid leukaemia, chronic / Chronic myeloid leukemia NOS (disorder)

Drug	Drug Name	Drug Description
DB12597	Asciminib	An inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
DB06616	Bosutinib	An antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
DB01254	Dasatinib	A tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy.
DB00694	Daunorubicin	An anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
DB04868	Nilotinib	A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
DB08901	Ponatinib	A kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).

Drug	Drug Name	Target	Type
DB12597	Asciminib	Cytochrome P450 3A4	enzyme
DB12597	Asciminib	UDP-glucuronosyltransferase 2B7	enzyme
DB12597	Asciminib	UDP-glucuronosyltransferase 2B17	enzyme
DB12597	Asciminib	Tyrosine-protein kinase ABL1	target
DB12597	Asciminib	ATP-binding cassette sub-family G member 2	transporter
DB12597	Asciminib	UDP-glucuronosyltransferase 1-1	enzyme
DB12597	Asciminib	Cytochrome P450 2C19	enzyme
DB12597	Asciminib	P-glycoprotein 1	transporter
DB12597	Asciminib	Solute carrier organic anion transporter family member 1B1	transporter
DB12597	Asciminib	Solute carrier organic anion transporter family member 1B3	transporter
DB12597	Asciminib	Solute carrier family 22 member 1	transporter
DB12597	Asciminib	Cytochrome P450 2C9	enzyme
DB06616	Bosutinib	Breakpoint cluster region protein	target
DB06616	Bosutinib	Tyrosine-protein kinase ABL1	target
DB06616	Bosutinib	Tyrosine-protein kinase Lyn	target
DB06616	Bosutinib	Tyrosine-protein kinase HCK	target
DB06616	Bosutinib	Proto-oncogene tyrosine-protein kinase Src	target
DB06616	Bosutinib	P-glycoprotein 1	transporter
DB06616	Bosutinib	Cytochrome P450 3A4	enzyme
DB06616	Bosutinib	Cyclin-dependent kinase 2	target
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 1	target
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 2	target
DB06616	Bosutinib	Mitogen-activated protein kinase kinase kinase 2	target
DB06616	Bosutinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	target
DB06616	Bosutinib	Cytochrome P450 2C8	enzyme
DB01254	Dasatinib	Tyrosine-protein kinase ABL1	target
DB01254	Dasatinib	Abelson tyrosine-protein kinase 2	target
DB01254	Dasatinib	Proto-oncogene tyrosine-protein kinase Src	target
DB01254	Dasatinib	Tyrosine-protein kinase Fyn	target
DB01254	Dasatinib	Tyrosine-protein kinase Lck	target
DB01254	Dasatinib	Tyrosine-protein kinase Yes	target
DB01254	Dasatinib	Mast/stem cell growth factor receptor Kit	target
DB01254	Dasatinib	Platelet-derived growth factor receptor beta	target
DB01254	Dasatinib	Ephrin type-A receptor 2	target
DB01254	Dasatinib	Signal transducer and activator of transcription 5B	target
DB01254	Dasatinib	Cytochrome P450 3A4	enzyme
DB01254	Dasatinib	P-glycoprotein 1	transporter
DB01254	Dasatinib	ATP-binding cassette sub-family G member 2	transporter
DB01254	Dasatinib	Cytochrome P450 1A1	enzyme
DB01254	Dasatinib	Cytochrome P450 1A2	enzyme
DB01254	Dasatinib	Cytochrome P450 1B1	enzyme
DB01254	Dasatinib	Cytochrome P450 3A5	enzyme
DB01254	Dasatinib	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
DB01254	Dasatinib	Tyrosine-protein kinase BTK	target
DB01254	Dasatinib	Nuclear receptor subfamily 4 group A member 3	target
DB01254	Dasatinib	Breakpoint cluster region protein	target
DB01254	Dasatinib	Tyrosine-protein kinase CSK	target
DB01254	Dasatinib	Ephrin type-A receptor 5	target
DB01254	Dasatinib	Ephrin type-B receptor 4	target
DB01254	Dasatinib	Tyrosine-protein kinase Fgr	target
DB01254	Dasatinib	Tyrosine-protein kinase FRK	target
DB01254	Dasatinib	Heat shock cognate 71 kDa protein	target
DB01254	Dasatinib	Tyrosine-protein kinase Lyn	target
DB01254	Dasatinib	Mitogen-activated protein kinase kinase kinase MLT	target
DB01254	Dasatinib	Mitogen-activated protein kinase 14	target
DB01254	Dasatinib	Amidophosphoribosyltransferase	target
DB00694	Daunorubicin	DNA	target
DB00694	Daunorubicin	Cytochrome P450 3A5	enzyme
DB00694	Daunorubicin	NADPH--cytochrome P450 reductase	enzyme
DB00694	Daunorubicin	P-glycoprotein 1	transporter
DB00694	Daunorubicin	Multidrug resistance-associated protein 1	transporter
DB00694	Daunorubicin	Multidrug resistance-associated protein 6	transporter
DB00694	Daunorubicin	Multidrug resistance-associated protein 7	transporter
DB00694	Daunorubicin	ATP-binding cassette sub-family G member 2	transporter
DB00694	Daunorubicin	DNA topoisomerase 2-alpha	target
DB00694	Daunorubicin	DNA topoisomerase 2-beta	target
DB00694	Daunorubicin	Cytochrome P450 1B1	enzyme
DB00694	Daunorubicin	Cytochrome P450 3A4	enzyme
DB00694	Daunorubicin	Aldose reductase	enzyme
DB00694	Daunorubicin	Carbonyl reductase [NADPH] 1	enzyme
DB00694	Daunorubicin	Carbonyl reductase [NADPH] 3	enzyme
DB04868	Nilotinib	Tyrosine-protein kinase ABL1	target
DB04868	Nilotinib	Mast/stem cell growth factor receptor Kit	target
DB04868	Nilotinib	Cytochrome P450 2D6	enzyme
DB04868	Nilotinib	Cytochrome P450 2C8	enzyme
DB04868	Nilotinib	Cytochrome P450 2C9	enzyme
DB04868	Nilotinib	Cytochrome P450 3A4	enzyme
DB04868	Nilotinib	P-glycoprotein 1	transporter
DB04868	Nilotinib	ATP-binding cassette sub-family G member 2	transporter
DB04868	Nilotinib	UDP-glucuronosyltransferase 1-1	transporter
DB04868	Nilotinib	Cytochrome P450 2B6	enzyme
DB04868	Nilotinib	Solute carrier organic anion transporter family member 1B1	transporter
DB08901	Ponatinib	Tyrosine-protein kinase ABL1	target
DB08901	Ponatinib	Breakpoint cluster region protein	target
DB08901	Ponatinib	Mast/stem cell growth factor receptor Kit	target
DB08901	Ponatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
DB08901	Ponatinib	Angiopoietin-1 receptor	target
DB08901	Ponatinib	Receptor-type tyrosine-protein kinase FLT3	target
DB08901	Ponatinib	Cytochrome P450 3A4	enzyme
DB08901	Ponatinib	Cytochrome P450 2C8	enzyme
DB08901	Ponatinib	Cytochrome P450 2D6	enzyme
DB08901	Ponatinib	Cytochrome P450 3A5	enzyme
DB08901	Ponatinib	P-glycoprotein 1	transporter
DB08901	Ponatinib	ATP-binding cassette sub-family G member 2	transporter
DB08901	Ponatinib	Fibroblast growth factor receptor 1	target
DB08901	Ponatinib	Fibroblast growth factor receptor 2	target
DB08901	Ponatinib	Fibroblast growth factor receptor 3	target
DB08901	Ponatinib	Fibroblast growth factor receptor 4	target
DB08901	Ponatinib	Tyrosine-protein kinase Lck	target
DB08901	Ponatinib	Proto-oncogene tyrosine-protein kinase Src	target
DB08901	Ponatinib	Tyrosine-protein kinase Lyn	target
DB08901	Ponatinib	Vascular endothelial growth factor receptor 2	target
DB08901	Ponatinib	Platelet-derived growth factor receptor alpha	target

Drug	Drug Name	Phase	Status	Count
DB06626	Axitinib	1	Terminated	1
DB06616	Bosutinib	1	Terminated	1
DB11752	Bryostatin 1	1	Completed	1
DB00531	Cyclophosphamide	1	Completed	1
DB00091	Cyclosporine	1	Completed	1
DB00091	Cyclosporine	1	Terminated	1
DB01254	Dasatinib	1	Completed	1
DB01254	Dasatinib	1	Terminated	1
DB01254	Dasatinib	1	Withdrawn	1
DB01073	Fludarabine	1	Completed	1
DB16185	HQP1351	1	Completed	1
DB00619	Imatinib	1	Completed	1
DB00619	Imatinib	1	Terminated	1
DB00619	Imatinib	1	Withdrawn	1
DB05258	Interferon alfa	1	Completed	1
DB14123	Menthol	1	Terminated	1
DB00688	Mycophenolate mofetil	1	Completed	1
DB04868	Nilotinib	1	Completed	1
DB00172	Proline	1	Completed	1
DB08877	Ruxolitinib	1	Completed	1
DB00020	Sargramostim	1	Completed	1
DB01268	Sunitinib	1	Completed	1
DB06287	Temsirolimus	1	Terminated	1
DB11595	Atezolizumab	1 / 2	Recruiting	1
DB11945	Avelumab	1 / 2	Recruiting	1
DB06616	Bosutinib	1 / 2	Recruiting	2
DB06616	Bosutinib	1 / 2	Terminated	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00091	Cyclosporine	1 / 2	Completed	1
DB00091	Cyclosporine	1 / 2	Recruiting	1
DB01254	Dasatinib	1 / 2	Terminated	1
DB01073	Fludarabine	1 / 2	Completed	1
DB00159	Icosapent	1 / 2	Terminated	1
DB00619	Imatinib	1 / 2	Completed	1
DB00619	Imatinib	1 / 2	Terminated	1
DB00563	Methotrexate	1 / 2	Recruiting	1
DB00688	Mycophenolate mofetil	1 / 2	Completed	1
DB00688	Mycophenolate mofetil	1 / 2	Recruiting	1
DB04868	Nilotinib	1 / 2	Completed	2
DB04868	Nilotinib	1 / 2	Terminated	1
DB11133	Omega-3 fatty acids	1 / 2	Terminated	1
DB15276	PR1 leukemia peptide vaccine	1 / 2	Completed	1
DB01132	Pioglitazone	1 / 2	Recruiting	1
DB08901	Ponatinib	1 / 2	Recruiting	1
DB08877	Ruxolitinib	1 / 2	Completed	1
DB00020	Sargramostim	1 / 2	Completed	1
DB00864	Tacrolimus	1 / 2	Recruiting	1
DB00135	Tyrosine	1 / 2	Terminated	1
DB02546	Vorinostat	1 / 2	Recruiting	1
DB00945	Acetylsalicylic acid	2	Recruiting	1
DB00087	Alemtuzumab	2	Completed	2
DB09312	Antilymphocyte immunoglobulin (horse)	2	Completed	2
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	2
DB12597	Asciminib	2	Recruiting	3
DB00394	Beclomethasone dipropionate	2	Completed	1
DB01008	Busulfan	2	Completed	4
DB15694	Cedazuridine	2	Recruiting	1
DB00531	Cyclophosphamide	2	Completed	5
DB00091	Cyclosporine	2	Completed	8
DB00987	Cytarabine	2	Completed	1
DB01254	Dasatinib	2	Active Not Recruiting	1
DB01254	Dasatinib	2	Completed	4
DB01254	Dasatinib	2	Recruiting	3
DB01254	Dasatinib	2	Unknown Status	1
DB01262	Decitabine	2	Recruiting	1
DB01609	Deferasirox	2	Terminated	1
DB00005	Etanercept	2	Completed	1
DB01073	Fludarabine	2	Completed	8
DB16185	HQP1351	2	Active Not Recruiting	2
DB01005	Hydroxyurea	2	Active Not Recruiting	1
DB00619	Imatinib	2	Active Not Recruiting	1
DB00619	Imatinib	2	Completed	5
DB00619	Imatinib	2	Recruiting	2
DB00619	Imatinib	2	Terminated	2
DB01026	Ketoconazole	2	Recruiting	1
DB01042	Melphalan	2	Completed	1
DB00563	Methotrexate	2	Completed	5
DB00959	Methylprednisolone	2	Completed	3
DB14644	Methylprednisolone hemisuccinate	2	Completed	3
DB00688	Mycophenolate mofetil	2	Completed	7
DB04868	Nilotinib	2	Active Not Recruiting	1
DB04868	Nilotinib	2	Completed	1
DB04868	Nilotinib	2	Recruiting	2
DB04868	Nilotinib	2	Terminated	1
DB04865	Omacetaxine mepesuccinate	2	Active Not Recruiting	1
DB04865	Omacetaxine mepesuccinate	2	Completed	2
DB04865	Omacetaxine mepesuccinate	2	Terminated	1
DB00904	Ondansetron	2	Completed	1
DB06603	Panobinostat	2	Terminated	1
DB01132	Pioglitazone	2	Completed	1
DB08901	Ponatinib	2	Active Not Recruiting	2
DB08901	Ponatinib	2	Recruiting	1
DB08877	Ruxolitinib	2	Recruiting	1
DB00877	Sirolimus	2	Terminated	1
DB01268	Sunitinib	2	Terminated	1
DB00864	Tacrolimus	2	Completed	5
DB00864	Tacrolimus	2	Terminated	1
DB17459	Therapeutic allogeneic lymphocytes	2	Completed	1
DB00135	Tyrosine	2	Recruiting	1
DB02546	Vorinostat	2	Completed	1
DB12597	Asciminib	3	Recruiting	1
DB01254	Dasatinib	3	Completed	2
DB01254	Dasatinib	3	Terminated	1
DB00099	Filgrastim	3	Completed	1
DB16185	HQP1351	3	Recruiting	1
DB00619	Imatinib	3	Active Not Recruiting	1
DB00619	Imatinib	3	Completed	1
DB00619	Imatinib	3	Terminated	2
DB04868	Nilotinib	3	Recruiting	1
DB04868	Nilotinib	3	Terminated	2
DB08901	Ponatinib	3	Terminated	1
DB12323	Radotinib	3	Active Not Recruiting	1
DB12323	Radotinib	3	Recruiting	1
DB01254	Dasatinib	4	Completed	2
DB01254	Dasatinib	4	Recruiting	1
DB11904	Flumatinib	4	Recruiting	2
DB04868	Nilotinib	4	Completed	1
DB09312	Antilymphocyte immunoglobulin (horse)	Not Available	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	Not Available	Completed	1
DB06616	Bosutinib	Not Available	Completed	1
DB00091	Cyclosporine	Not Available	Completed	2
DB01254	Dasatinib	Not Available	Completed	2
DB00099	Filgrastim	Not Available	Terminated	1
DB01073	Fludarabine	Not Available	Completed	3
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB00619	Imatinib	Not Available	Completed	3
DB14509	Lithium carbonate	Not Available	Completed	1
DB01042	Melphalan	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	Completed	2
DB04868	Nilotinib	Not Available	Completed	1
DB00039	Palifermin	Not Available	Completed	1
DB06809	Plerixafor	Not Available	Terminated	1
DB17459	Therapeutic allogeneic lymphocytes	Not Available	Completed	1
DB01610	Valganciclovir	Not Available	Completed	1