Myeloid Leukemia, Chronic, Chronic Phase

Also known as: Leukemia, Myeloid, Chronic-Phase (CML-CP) / Chronic Myeloid Leukemia in Chronic Phase / Chronic Phase of Chronic Myeloid Leukemia / Myeloid Leukemia, Chronic, Chronic-Phase / Leukemia, Myeloid, Chronic Phase / Chronic Phase-Chronic Myeloid Leukemia / Leukemia, Myeloid, Chronic-Phase / Chronic Myeloid Leukemia, Chronic Phase / Chronic Phase Chronic Myeloid Leukemia / Chronic Myeloid Leukemia - Chronic Phase / Leukemia, Myelogenous, Chronic Phase / Myelogenous Leukemia, Chronic, Chronic Phase / Chronic Myelogenous Leukemia - Chronic Phase / Chronic Phase Chronic Myelogenous Leukemia / Chronic phase chronic myeloid leukemia (disorder) / Chronic phase chronic myeloid leukaemia / Chronic myeloid leukemia (morphologic abnormality) / Myeloid leukemia, chronic / Chronic myeloid leukemia, disease (disorder) / Chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality) / Chronic myeloid leukaemia / Chronic myeloid leukemia / CML / Chronic myelogenous leukaemia / Chronic myelocytic leukaemia / Leukemia myelocytic chronic / Chronic myelogenous leukemia / Leukaemia myelocytic chronic / Chronic granulocytic leukemia / Leukaemias chronic myeloid / Chronic myelocytic leukemia / Chronic granulocytic leukaemia / Myeloid leukaemia, chronic / Chronic myeloid leukemia NOS (disorder)

DrugDrug NameDrug Description
DB12597AsciminibAn inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
DB06616BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
DB01254DasatinibA tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy.
DB00694DaunorubicinAn anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
DB04868NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
DB08901PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
DrugDrug NameTargetType
DB12597AsciminibCytochrome P450 3A4enzyme
DB12597AsciminibUDP-glucuronosyltransferase 2B7enzyme
DB12597AsciminibUDP-glucuronosyltransferase 2B17enzyme
DB12597AsciminibTyrosine-protein kinase ABL1target
DB12597AsciminibATP-binding cassette sub-family G member 2transporter
DB12597AsciminibUDP-glucuronosyltransferase 1-1enzyme
DB12597AsciminibCytochrome P450 2C19enzyme
DB12597AsciminibP-glycoprotein 1transporter
DB12597AsciminibSolute carrier organic anion transporter family member 1B1transporter
DB12597AsciminibSolute carrier organic anion transporter family member 1B3transporter
DB12597AsciminibSolute carrier family 22 member 1transporter
DB12597AsciminibCytochrome P450 2C9enzyme
DB06616BosutinibBreakpoint cluster region proteintarget
DB06616BosutinibTyrosine-protein kinase ABL1target
DB06616BosutinibTyrosine-protein kinase Lyntarget
DB06616BosutinibTyrosine-protein kinase HCKtarget
DB06616BosutinibProto-oncogene tyrosine-protein kinase Srctarget
DB06616BosutinibP-glycoprotein 1transporter
DB06616BosutinibCytochrome P450 3A4enzyme
DB06616BosutinibCyclin-dependent kinase 2target
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 1target
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 2target
DB06616BosutinibMitogen-activated protein kinase kinase kinase 2target
DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
DB06616BosutinibCytochrome P450 2C8enzyme
DB01254DasatinibTyrosine-protein kinase ABL1target
DB01254DasatinibAbelson tyrosine-protein kinase 2target
DB01254DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DB01254DasatinibTyrosine-protein kinase Fyntarget
DB01254DasatinibTyrosine-protein kinase Lcktarget
DB01254DasatinibTyrosine-protein kinase Yestarget
DB01254DasatinibMast/stem cell growth factor receptor Kittarget
DB01254DasatinibPlatelet-derived growth factor receptor betatarget
DB01254DasatinibEphrin type-A receptor 2target
DB01254DasatinibSignal transducer and activator of transcription 5Btarget
DB01254DasatinibCytochrome P450 3A4enzyme
DB01254DasatinibP-glycoprotein 1transporter
DB01254DasatinibATP-binding cassette sub-family G member 2transporter
DB01254DasatinibCytochrome P450 1A1enzyme
DB01254DasatinibCytochrome P450 1A2enzyme
DB01254DasatinibCytochrome P450 1B1enzyme
DB01254DasatinibCytochrome P450 3A5enzyme
DB01254DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB01254DasatinibTyrosine-protein kinase BTKtarget
DB01254DasatinibNuclear receptor subfamily 4 group A member 3target
DB01254DasatinibBreakpoint cluster region proteintarget
DB01254DasatinibTyrosine-protein kinase CSKtarget
DB01254DasatinibEphrin type-A receptor 5target
DB01254DasatinibEphrin type-B receptor 4target
DB01254DasatinibTyrosine-protein kinase Fgrtarget
DB01254DasatinibTyrosine-protein kinase FRKtarget
DB01254DasatinibHeat shock cognate 71 kDa proteintarget
DB01254DasatinibTyrosine-protein kinase Lyntarget
DB01254DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB01254DasatinibMitogen-activated protein kinase 14target
DB01254DasatinibAmidophosphoribosyltransferasetarget
DB00694DaunorubicinDNAtarget
DB00694DaunorubicinCytochrome P450 3A5enzyme
DB00694DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DB00694DaunorubicinP-glycoprotein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 6transporter
DB00694DaunorubicinMultidrug resistance-associated protein 7transporter
DB00694DaunorubicinATP-binding cassette sub-family G member 2transporter
DB00694DaunorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinDNA topoisomerase 2-betatarget
DB00694DaunorubicinCytochrome P450 1B1enzyme
DB00694DaunorubicinCytochrome P450 3A4enzyme
DB00694DaunorubicinAldose reductaseenzyme
DB00694DaunorubicinCarbonyl reductase [NADPH] 1enzyme
DB00694DaunorubicinCarbonyl reductase [NADPH] 3enzyme
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibP-glycoprotein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibCytochrome P450 2B6enzyme
DB04868NilotinibSolute carrier organic anion transporter family member 1B1transporter
DB08901PonatinibTyrosine-protein kinase ABL1target
DB08901PonatinibBreakpoint cluster region proteintarget
DB08901PonatinibMast/stem cell growth factor receptor Kittarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08901PonatinibAngiopoietin-1 receptortarget
DB08901PonatinibReceptor-type tyrosine-protein kinase FLT3target
DB08901PonatinibCytochrome P450 3A4enzyme
DB08901PonatinibCytochrome P450 2C8enzyme
DB08901PonatinibCytochrome P450 2D6enzyme
DB08901PonatinibCytochrome P450 3A5enzyme
DB08901PonatinibP-glycoprotein 1transporter
DB08901PonatinibATP-binding cassette sub-family G member 2transporter
DB08901PonatinibFibroblast growth factor receptor 1target
DB08901PonatinibFibroblast growth factor receptor 2target
DB08901PonatinibFibroblast growth factor receptor 3target
DB08901PonatinibFibroblast growth factor receptor 4target
DB08901PonatinibTyrosine-protein kinase Lcktarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase Srctarget
DB08901PonatinibTyrosine-protein kinase Lyntarget
DB08901PonatinibVascular endothelial growth factor receptor 2target
DB08901PonatinibPlatelet-derived growth factor receptor alphatarget
DrugDrug NamePhaseStatusCount
DB06626Axitinib1Terminated1
DB06616Bosutinib1Terminated1
DB11752Bryostatin 11Completed1
DB00531Cyclophosphamide1Completed1
DB00091Cyclosporine1Completed1
DB00091Cyclosporine1Terminated1
DB01254Dasatinib1Completed1
DB01254Dasatinib1Terminated1
DB01254Dasatinib1Withdrawn1
DB01073Fludarabine1Completed1
DB16185HQP13511Completed1
DB00619Imatinib1Completed1
DB00619Imatinib1Terminated1
DB00619Imatinib1Withdrawn1
DB05258Interferon alfa1Completed1
DB14123Menthol1Terminated1
DB00688Mycophenolate mofetil1Completed1
DB04868Nilotinib1Completed1
DB00172Proline1Completed1
DB08877Ruxolitinib1Completed1
DB00020Sargramostim1Completed1
DB01268Sunitinib1Completed1
DB06287Temsirolimus1Terminated1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Recruiting1
DB06616Bosutinib1 / 2Recruiting2
DB06616Bosutinib1 / 2Terminated1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Completed1
DB00091Cyclosporine1 / 2Recruiting1
DB01254Dasatinib1 / 2Terminated1
DB01073Fludarabine1 / 2Completed1
DB00159Icosapent1 / 2Terminated1
DB00619Imatinib1 / 2Completed1
DB00619Imatinib1 / 2Terminated1
DB00563Methotrexate1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Completed1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB04868Nilotinib1 / 2Completed2
DB04868Nilotinib1 / 2Terminated1
DB11133Omega-3 fatty acids1 / 2Terminated1
DB15276PR1 leukemia peptide vaccine1 / 2Completed1
DB01132Pioglitazone1 / 2Recruiting1
DB08901Ponatinib1 / 2Recruiting1
DB08877Ruxolitinib1 / 2Completed1
DB00020Sargramostim1 / 2Completed1
DB00864Tacrolimus1 / 2Recruiting1
DB00135Tyrosine1 / 2Terminated1
DB02546Vorinostat1 / 2Recruiting1
DB00945Acetylsalicylic acid2Recruiting1
DB00087Alemtuzumab2Completed2
DB09312Antilymphocyte immunoglobulin (horse)2Completed2
DB00098Antithymocyte immunoglobulin (rabbit)2Completed2
DB12597Asciminib2Recruiting3
DB00394Beclomethasone dipropionate2Completed1
DB01008Busulfan2Completed4
DB15694Cedazuridine2Recruiting1
DB00531Cyclophosphamide2Completed5
DB00091Cyclosporine2Completed8
DB00987Cytarabine2Completed1
DB01254Dasatinib2Active Not Recruiting1
DB01254Dasatinib2Completed4
DB01254Dasatinib2Recruiting3
DB01254Dasatinib2Unknown Status1
DB01262Decitabine2Recruiting1
DB01609Deferasirox2Terminated1
DB00005Etanercept2Completed1
DB01073Fludarabine2Completed8
DB16185HQP13512Active Not Recruiting2
DB01005Hydroxyurea2Active Not Recruiting1
DB00619Imatinib2Active Not Recruiting1
DB00619Imatinib2Completed5
DB00619Imatinib2Recruiting2
DB00619Imatinib2Terminated2
DB01026Ketoconazole2Recruiting1
DB01042Melphalan2Completed1
DB00563Methotrexate2Completed5
DB00959Methylprednisolone2Completed3
DB14644Methylprednisolone hemisuccinate2Completed3
DB00688Mycophenolate mofetil2Completed7
DB04868Nilotinib2Active Not Recruiting1
DB04868Nilotinib2Completed1
DB04868Nilotinib2Recruiting2
DB04868Nilotinib2Terminated1
DB04865Omacetaxine mepesuccinate2Active Not Recruiting1
DB04865Omacetaxine mepesuccinate2Completed2
DB04865Omacetaxine mepesuccinate2Terminated1
DB00904Ondansetron2Completed1
DB06603Panobinostat2Terminated1
DB01132Pioglitazone2Completed1
DB08901Ponatinib2Active Not Recruiting2
DB08901Ponatinib2Recruiting1
DB08877Ruxolitinib2Recruiting1
DB00877Sirolimus2Terminated1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Completed5
DB00864Tacrolimus2Terminated1
DB17459Therapeutic allogeneic lymphocytes2Completed1
DB00135Tyrosine2Recruiting1
DB02546Vorinostat2Completed1
DB12597Asciminib3Recruiting1
DB01254Dasatinib3Completed2
DB01254Dasatinib3Terminated1
DB00099Filgrastim3Completed1
DB16185HQP13513Recruiting1
DB00619Imatinib3Active Not Recruiting1
DB00619Imatinib3Completed1
DB00619Imatinib3Terminated2
DB04868Nilotinib3Recruiting1
DB04868Nilotinib3Terminated2
DB08901Ponatinib3Terminated1
DB12323Radotinib3Active Not Recruiting1
DB12323Radotinib3Recruiting1
DB01254Dasatinib4Completed2
DB01254Dasatinib4Recruiting1
DB11904Flumatinib4Recruiting2
DB04868Nilotinib4Completed1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableCompleted1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB06616BosutinibNot AvailableCompleted1
DB00091CyclosporineNot AvailableCompleted2
DB01254DasatinibNot AvailableCompleted2
DB00099FilgrastimNot AvailableTerminated1
DB01073FludarabineNot AvailableCompleted3
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB00619ImatinibNot AvailableCompleted3
DB14509Lithium carbonateNot AvailableCompleted1
DB01042MelphalanNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted2
DB04868NilotinibNot AvailableCompleted1
DB00039PaliferminNot AvailableCompleted1
DB06809PlerixaforNot AvailableTerminated1
DB17459Therapeutic allogeneic lymphocytesNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1