Conjunctivitis (DBCOND0009989)

Identifiers

Synonyms

Pinkeye / Keratoconjunctivitis caused by Moraxella bovis (disorder) / Unspecified conjunctivitis / Conjunctivitis, unspecified / Conjunctivitis NOS / Conjunctivitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Anthoxanthum odoratum	An extract from Anthoxanthum odoratum used in allergy testing.	No drug targets
Anthoxanthum odoratum pollen	An extract from Anthoxanthum odoratum pollen used in allergy testing.	No drug targets
Bacitracin	A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.	Alpha-2-macroglobulintarget Insulin-degrading enzymetarget C55-isoprenyl pyrophosphatetarget Bacitracin transport ATP-binding protein BcrAtransporter Bacitracin transport permease protein BCRBtransporter Bacitracin transport permease protein BcrCtransporter
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Dactylis glomerata pollen	An extract from Dactylis glomerata pollen used in allergy testing.	No drug targets
Dermatophagoides farinae	An extract from Dermatophagoides farinae used in allergy testing.	No drug targets
Dermatophagoides pteronyssinus	An extract from Dermatophagoides pteronyssinus used in allergy testing.	No drug targets
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Dexchlorpheniramine	A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin.	Cytochrome P450 2D6enzyme
Framycetin	An aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus.	30S ribosomal protein S12target 16S ribosomal RNAtarget C-X-C chemokine receptor type 4target
Gramicidin D	A bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.	ATP-dependent translocase ABCB1transporter Dihydropteroate synthasetarget
Hyaluronic acid	A glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.	CD44 antigentarget Intercellular adhesion molecule 1target Hyaluronan mediated motility receptortarget Neurocan core proteintarget Versican core proteintarget Complement component 1 Q subcomponent-binding protein, mitochondrialtarget Hyaluronan and proteoglycan link protein 1target Hyaluronan and proteoglycan link protein 3target Hyaluronan-binding protein 2target Layilintarget Stabilin-2target Tumor necrosis factor-inducible gene 6 proteintarget Interphotoreceptor matrix proteoglycan 2target Intracellular hyaluronan-binding protein 4target Hyaluronidase enzymesenzyme ATP-binding cassette sub-family C member 5transporter Lymphatic vessel endothelial hyaluronic acid receptor 1target
Hydrocortisone acetate	A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter
Lolium perenne pollen	An extract from Lolium perenne pollen used in allergy testing.	No drug targets
Naphazoline	A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget D(2) dopamine receptortarget
Ofloxacin	An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Organic cation/carnitine transporter 2transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Bile salt export pumptransporter DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Phleum pratense pollen	An extract from Phleum pratense pollen used in allergy testing.	No drug targets
Poa pratensis pollen	An extract from Poa pratensis pollen used in allergy testing.	No drug targets
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Sodium borate	No FDA- or EMA-approved therapeutic indications on its own.	No drug targets
Sulfacetamide	A sulfonamide used to treat inflammatory ocular conditions and acne vulgaris.	Dihydropteroate synthasetarget Dihydropteroate synthase type-1target Folic acid synthesis protein FOL1target
Sulfamerazine	An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.	Dihydropteroate synthasetarget Albumincarrier
Tetracosactide	A diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.	Adrenocorticotropic hormone receptortarget
Tetryzoline	An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.	Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Alpha-2C adrenergic receptortarget
Zinc phenolsulfonate	An ingredient in ophthalmic solutions indicated in the treatment of minor irritation and conjunctivitis.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04397666	RT-PCR on Conjunctival Sample for the Detection of SARS-CoV-2 in Patients With Covid-19	No drug interventions	other	Not Available	unknown_status
NCT00783198	Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05233)(COMPLETED)	No drug interventions	treatment	2 / 3	completed
NCT06469697	Zanzibar Arts for Children's Eyesight Pilot Trial	No drug interventions	prevention	Not Available	active_not_recruiting
NCT01385371	A Study of SCH 697243 in Participants With Grass Pollen Allergy Symptoms, With or Without Asthma (P08067)	No drug interventions	treatment	3	completed
NCT00581542	Moxifloxacin vs. Polytrim for Conjunctivitis	Moxifloxacin Polymyxin B Trimethoprim	treatment	4	completed
NCT00567918	Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis	Tacrolimus	treatment	3	completed
NCT04984941	Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients	No drug interventions	Not Available	Not Available	completed
NCT00001734	Screening for NEI Clinical Studies	No drug interventions	Not Available	Not Available	completed
NCT03519516	Safety and Tolerability of the PRO-174 Versus Sophixín Ofteno®, on the Ocular Surface of Healthy Subjects	Ciprofloxacin Levofloxacin	treatment	1	completed
NCT01600365	Evaluate the Use of Ganciclovir Gel 0.3% for the Treatment of Conjunctivitis Caused by Adenovirus	Ganciclovir	treatment	3	unknown_status
NCT02795273	Efficacy and Safety of Grass-SPIRE Registration Study	No drug interventions	treatment	2 / 3	withdrawn
NCT04346160	A Study to Assess the Virus RNA, and miRNA Levels Related to Viral Infection, and Inflammatory Response in Tears of Patients Affected by COVID-19 Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT00567762	Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis	Tacrolimus	treatment	3	completed
NCT00550550	Efficacy and Safety of Grass Sublingual Tablet in Children and Adolescents (P05239 AM3)(COMPLETED)	Albuterol Fluticasone propionate Loratadine Mometasone furoate Olopatadine Prednisone	treatment	3	completed
NCT03631108	Feasibility Study and Preliminary Application Study on Iris OCTA	No drug interventions	Not Available	Not Available	unknown_status
NCT00857779	Study on Pharmacodynamic Parameter and Tolerability With Subcutaneous Immunotherapy in Grass Pollen Allergic Patients	No drug interventions	treatment	2	completed
NCT06229379	The Effects of a Large Language Model on Clinical Questioning Skills	No drug interventions	other	Not Available	recruiting
NCT03753893	Ocular Manifestations in Rheumatic Diseases	No drug interventions	Not Available	Not Available	completed
NCT04374656	Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients With Conjunctivitis During the COVID-19 Pandemic	No drug interventions	Not Available	Not Available	completed
NCT02503956	Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients	No drug interventions	treatment	Not Available	completed
NCT00770315	Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet (SCH 39641) in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234)	No drug interventions	treatment	2 / 3	completed
NCT06092515	Efficacy of Zinc Fortified Fermented Wheat Flour	No drug interventions	prevention	Not Available	completed
NCT00522600	Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations	No drug interventions	Not Available	Not Available	completed
NCT00705159	Safety and Efficacy of Zylet vs Lotemax, Tobramycin and Vehicle in Pediatric Blepharoconjunctivitis	Loteprednol etabonate Tobramycin	treatment	4	completed
NCT00562159	Efficacy and Safety of Grass Sublingual Tablet in Adults (P05238 AM3)(COMPLETED)	Albuterol Fluticasone propionate Loratadine Mometasone Mometasone furoate Olopatadine Prednisone	treatment	3	completed
NCT04709575	Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis	Atisnolerbart Bremzalerbart	treatment	3	completed
NCT05430919	Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants	Atisnolerbart Bremzalerbart	treatment	2	completed
NCT00008541	Evaluation and Treatment of Patients With Corneal and External Diseases	No drug interventions	Not Available	Not Available	completed
NCT04837534	Improving the Follow up Rate for Pediatric Patients	No drug interventions	health_services_research	Not Available	completed
NCT01028027	Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis	Dexamethasone Loteprednol etabonate Tobramycin	treatment	3	completed
NCT00978029	Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081)	No drug interventions	treatment	2	completed
NCT00623701	Efficacy and Safety From a High-dosed Sublingual Grass Pollen Preparation	No drug interventions	treatment	3	completed
NCT00732446	Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis	Dexamethasone Moxifloxacin	treatment	3	completed
NCT00921895	A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis	No drug interventions	diagnostic	Not Available	completed
NCT02472223	Reducing Adenoviral Patient Infected Days	Povidone-iodine	treatment	Not Available	completed
NCT04287608	Observational Study of Conjunctivitis in the Setting of DUPIXENT® Treatment for Atopic Dermatitis	Dupilumab	Not Available	Not Available	completed