acute Manic episode (DBCOND0024512)

Identifiers

Synonyms

Manic Episode / Acute Manic Episode / Manic episode, unspecified / Mania / Manic state / Mania (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aripiprazole	An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.	D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Etarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Histamine H1 receptortarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 5Atarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Histamine H2 receptortarget Histamine H3 receptortarget Histamine H4 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Kappa-type opioid receptortarget Mu-type opioid receptortarget Delta-type opioid receptortarget Glutamate (NMDA) receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent serotonin transportertarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Asenapine	An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.	5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Alpha-1A adrenergic receptortarget D(1A) dopamine receptortarget D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Histamine H1 receptortarget Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 5Atarget UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 3A4enzyme Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Albumincarrier alpha1-acid glycoproteincarrier
Clonazepam	A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.	Cytochrome P450 3A4enzyme Albumincarrier Cytochrome P450 2E1enzyme Arylamine N-acetyltransferase 2enzyme GABA(A) Receptortarget Nuclear receptor subfamily 1 group I member 2target GABA(A) Receptor Benzodiazepine Binding Sitetarget
Lithium carbonate	A medication used to treat manic episodes of bipolar disorder.	Inositol monophosphatase 2target Inositol monophosphatase 1target Glycogen synthase kinase-3 betatarget Glutamate receptor 3target Amiloride-sensitive sodium channel subunit alphatransporter Amiloride-sensitive sodium channel subunit betatransporter Amiloride-sensitive sodium channel subunit gammatransporter
Lithium cation	A drug used for the management of bipolar disorder and other psychiatric conditions.	Inositol monophosphatase 2target Inositol monophosphatase 1target Glycogen synthase kinase-3 betatarget Glutamate receptor 3target
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.	D(1A) dopamine receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target 5-hydroxytryptamine receptor 2Atarget D(4) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M2target D(2) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget D(3) dopamine receptortarget Alpha-1B adrenergic receptortarget Cytochrome P450 1A2enzyme 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target Alpha-1A adrenergic receptortarget D(1B) dopamine receptortarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Flavin-containing monooxygenase 3enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme D(1) dopamine receptortarget Beta adrenergic receptortarget 5-hydroxytryptamine receptor 1target GABA(A) Receptor Benzodiazepine Binding Sitetarget Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A Subfamilyenzyme
Quetiapine	An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.	5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget Histamine H1 receptortarget Cytochrome P450 3A4enzyme Alpha-1 adrenergic receptorstarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 1Dtarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target D(1B) dopamine receptortarget D(1A) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A7enzyme
Risperidone	A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.	Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier 5-hydroxytryptamine receptor 2Atarget D(2) dopamine receptortarget Alpha-1B adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-1A adrenergic receptortarget Alpha-2C adrenergic receptortarget Histamine H1 receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 7target D(1A) dopamine receptortarget
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.	Histone deacetylase 9target Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A9enzyme Prostaglandin G/H synthase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A10enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme 2-oxoglutarate dehydrogenase complex component E1target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Sodium channel proteintarget Histone deacetylase 2target Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor deltatarget Peroxisome proliferator-activated receptor gammatarget Albumincarrier UDP-glucuronosyltransferase 1A1enzyme Solute carrier organic anion transporter family member 2B1transporter Histone deacetylasetarget Cyclin-dependent kinase inhibitor 1target Hepatocyte growth factortarget Ornithine decarboxylasetarget Programmed cell death 1 ligand 1target 4-aminobutyrate aminotransferase, mitochondrialtarget Glycogen synthase kinase-3 alphatarget
Ziprasidone	An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.	Alpha-1A adrenergic receptortarget D(2) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget D(3) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Dtarget Histamine H1 receptortarget 5-hydroxytryptamine receptor 2Atarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 7target Cytochrome P450 3A4enzyme Alpha-2A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 6target Aldehyde oxidaseenzyme Albumincarrier ATP-dependent translocase ABCB1transporter Alpha-1-acid glycoprotein 1carrier 5-hydroxytryptamine 3 receptortarget 5-hydroxytryptamine receptor 5Atarget Neuronal acetylcholine receptor subunit alpha-7target
Zuclopenthixol	An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance.	D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(2) dopamine receptortarget Cytochrome P450 2D6enzyme Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget 5-hydroxytryptamine receptor 2Atarget Histamine H1 receptortarget Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00249236	A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder	Risperidone	treatment	3	completed
NCT05956340	A Study of Spoken Language in Mania	No drug interventions	supportive_care	Not Available	recruiting
NCT03259555	A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I Disorder	Brexpiprazole	treatment	3	completed
NCT05622552	Effect of tDCS Combined With Pharmacological Treatments for Bipolar Mania	No drug interventions	treatment	Not Available	recruiting
NCT00257075	A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder	Risperidone	treatment	3	completed
NCT06426134	Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03257865	A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes, Associated With Bipolar I Disorder	Brexpiprazole	treatment	3	completed