Chronic Myelogenous Leukemia (CML) in Blast Crisis

Also known as: Chronic Myelogenous Leukemia With Crisis of Blast Cells / Blast phase Chronic myeloid leukemia / Chronic Myelogenous Leukemia in Blast Crisis / Blastic Phase Chronic Myelogenous Leukemia / Blast-phase Chronic Myelogenous Leukemia / Blast phase Chronic myelocytic leukemia / Chronic Myelogenous Leukemia, Blastic Phase / Chronic Myeloid Leukemia, Blast Crisis / Blastic Phase Chronic Myeloid Leukemia / Blast Phase Chronic Myelogenous Leukemia (CML) / Blast phase Chronic myelogenous leukemia

Drug	Drug Name	Drug Description
DB06616	Bosutinib	An antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
DB00987	Cytarabine	A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia.
DB01254	Dasatinib	A tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
DB00619	Imatinib	A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB08901	Ponatinib	A kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).

Drug	Drug Name	Target	Type
DB06616	Bosutinib	Breakpoint cluster region protein	target
DB06616	Bosutinib	Tyrosine-protein kinase ABL1	target
DB06616	Bosutinib	Tyrosine-protein kinase Lyn	target
DB06616	Bosutinib	Tyrosine-protein kinase HCK	target
DB06616	Bosutinib	Proto-oncogene tyrosine-protein kinase Src	target
DB06616	Bosutinib	P-glycoprotein 1	transporter
DB06616	Bosutinib	Cytochrome P450 3A4	enzyme
DB06616	Bosutinib	Cyclin-dependent kinase 2	target
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 1	target
DB06616	Bosutinib	Dual specificity mitogen-activated protein kinase kinase 2	target
DB06616	Bosutinib	Mitogen-activated protein kinase kinase kinase 2	target
DB06616	Bosutinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	target
DB06616	Bosutinib	Cytochrome P450 2C8	enzyme
DB00987	Cytarabine	DNA polymerase beta	target
DB00987	Cytarabine	Cytidine deaminase	enzyme
DB00987	Cytarabine	Solute carrier family 22 member 4	transporter
DB00987	Cytarabine	Multidrug resistance-associated protein 7	transporter
DB00987	Cytarabine	Equilibrative nucleoside transporter 1	transporter
DB00987	Cytarabine	DNA	target
DB00987	Cytarabine	Cytochrome P450 3A4	enzyme
DB00987	Cytarabine	Deoxycytidine kinase	enzyme
DB00987	Cytarabine	5'-nucleotidase	enzyme
DB00987	Cytarabine	Deoxycytidylate deaminase	enzyme
DB01254	Dasatinib	Tyrosine-protein kinase ABL1	target
DB01254	Dasatinib	Abelson tyrosine-protein kinase 2	target
DB01254	Dasatinib	Proto-oncogene tyrosine-protein kinase Src	target
DB01254	Dasatinib	Tyrosine-protein kinase Fyn	target
DB01254	Dasatinib	Tyrosine-protein kinase Lck	target
DB01254	Dasatinib	Tyrosine-protein kinase Yes	target
DB01254	Dasatinib	Mast/stem cell growth factor receptor Kit	target
DB01254	Dasatinib	Platelet-derived growth factor receptor beta	target
DB01254	Dasatinib	Ephrin type-A receptor 2	target
DB01254	Dasatinib	Signal transducer and activator of transcription 5B	target
DB01254	Dasatinib	Cytochrome P450 3A4	enzyme
DB01254	Dasatinib	P-glycoprotein 1	transporter
DB01254	Dasatinib	ATP-binding cassette sub-family G member 2	transporter
DB01254	Dasatinib	Cytochrome P450 1A1	enzyme
DB01254	Dasatinib	Cytochrome P450 1A2	enzyme
DB01254	Dasatinib	Cytochrome P450 1B1	enzyme
DB01254	Dasatinib	Cytochrome P450 3A5	enzyme
DB01254	Dasatinib	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
DB01254	Dasatinib	Tyrosine-protein kinase BTK	target
DB01254	Dasatinib	Nuclear receptor subfamily 4 group A member 3	target
DB01254	Dasatinib	Breakpoint cluster region protein	target
DB01254	Dasatinib	Tyrosine-protein kinase CSK	target
DB01254	Dasatinib	Ephrin type-A receptor 5	target
DB01254	Dasatinib	Ephrin type-B receptor 4	target
DB01254	Dasatinib	Tyrosine-protein kinase Fgr	target
DB01254	Dasatinib	Tyrosine-protein kinase FRK	target
DB01254	Dasatinib	Heat shock cognate 71 kDa protein	target
DB01254	Dasatinib	Tyrosine-protein kinase Lyn	target
DB01254	Dasatinib	Mitogen-activated protein kinase kinase kinase MLT	target
DB01254	Dasatinib	Mitogen-activated protein kinase 14	target
DB01254	Dasatinib	Amidophosphoribosyltransferase	target
DB00619	Imatinib	Platelet-derived growth factor receptor beta	target
DB00619	Imatinib	Tyrosine-protein kinase ABL1	target
DB00619	Imatinib	Mast/stem cell growth factor receptor Kit	target
DB00619	Imatinib	RET proto-oncogene	target
DB00619	Imatinib	High affinity nerve growth factor receptor	target
DB00619	Imatinib	Macrophage colony-stimulating factor 1 receptor	target
DB00619	Imatinib	Platelet-derived growth factor receptor alpha	target
DB00619	Imatinib	Epithelial discoidin domain-containing receptor 1	target
DB00619	Imatinib	Cytochrome P450 3A4	enzyme
DB00619	Imatinib	Breakpoint cluster region protein	target
DB00619	Imatinib	Cytochrome P450 1A2	enzyme
DB00619	Imatinib	Cytochrome P450 2D6	enzyme
DB00619	Imatinib	Cytochrome P450 2C9	enzyme
DB00619	Imatinib	Cytochrome P450 2C19	enzyme
DB00619	Imatinib	Cytochrome P450 3A5	enzyme
DB00619	Imatinib	Cytochrome P450 3A7	enzyme
DB00619	Imatinib	Solute carrier family 22 member 1	transporter
DB00619	Imatinib	P-glycoprotein 1	transporter
DB00619	Imatinib	Solute carrier family 22 member 2	transporter
DB00619	Imatinib	ATP-binding cassette sub-family G member 2	transporter
DB00619	Imatinib	ATP-binding cassette sub-family A member 3	transporter
DB00619	Imatinib	Serum albumin	carrier
DB00619	Imatinib	Alpha-1-acid glycoprotein 1	carrier
DB00619	Imatinib	Bile salt export pump	transporter
DB00619	Imatinib	Cytochrome P450 2C8	enzyme
DB00619	Imatinib	Canalicular multispecific organic anion transporter 1	transporter
DB00619	Imatinib	Multidrug resistance-associated protein 1	transporter
DB00619	Imatinib	Solute carrier family 22 member 5	transporter
DB00619	Imatinib	Solute carrier organic anion transporter family member 1B3	transporter
DB00619	Imatinib	Multidrug resistance-associated protein 4	transporter
DB00619	Imatinib	Solute carrier organic anion transporter family member 1A2	transporter
DB00619	Imatinib	Discoidin domain-containing receptor 2	target
DB08901	Ponatinib	Tyrosine-protein kinase ABL1	target
DB08901	Ponatinib	Breakpoint cluster region protein	target
DB08901	Ponatinib	Mast/stem cell growth factor receptor Kit	target
DB08901	Ponatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
DB08901	Ponatinib	Angiopoietin-1 receptor	target
DB08901	Ponatinib	Receptor-type tyrosine-protein kinase FLT3	target
DB08901	Ponatinib	Cytochrome P450 3A4	enzyme
DB08901	Ponatinib	Cytochrome P450 2C8	enzyme
DB08901	Ponatinib	Cytochrome P450 2D6	enzyme
DB08901	Ponatinib	Cytochrome P450 3A5	enzyme
DB08901	Ponatinib	P-glycoprotein 1	transporter
DB08901	Ponatinib	ATP-binding cassette sub-family G member 2	transporter
DB08901	Ponatinib	Fibroblast growth factor receptor 1	target
DB08901	Ponatinib	Fibroblast growth factor receptor 2	target
DB08901	Ponatinib	Fibroblast growth factor receptor 3	target
DB08901	Ponatinib	Fibroblast growth factor receptor 4	target
DB08901	Ponatinib	Tyrosine-protein kinase Lck	target
DB08901	Ponatinib	Proto-oncogene tyrosine-protein kinase Src	target
DB08901	Ponatinib	Tyrosine-protein kinase Lyn	target
DB08901	Ponatinib	Vascular endothelial growth factor receptor 2	target
DB08901	Ponatinib	Platelet-derived growth factor receptor alpha	target

Drug	Drug Name	Phase	Status	Count
DB02594	2'-Deoxycytidine	1	Completed	1
DB01933	7-Hydroxystaurosporine	1	Completed	1
DB03496	Alvocidib	1	Completed	1
DB03496	Alvocidib	1	Terminated	1
DB06626	Axitinib	1	Terminated	1
DB12234	BMS-214662	1	Completed	1
DB06362	Becatecarin	1	Completed	1
DB00188	Bortezomib	1	Completed	2
DB16741	Bortezomib D-mannitol	1	Completed	1
DB06616	Bosutinib	1	Terminated	1
DB11752	Bryostatin 1	1	Completed	1
DB00987	Cytarabine	1	Completed	3
DB00987	Cytarabine	1	Terminated	1
DB11651	Dactolisib	1	Completed	1
DB01254	Dasatinib	1	Completed	1
DB01262	Decitabine	1	Completed	1
DB00380	Dexrazoxane	1	Terminated	1
DB00997	Doxorubicin	1	Terminated	1
DB11841	Entinostat	1	Terminated	1
DB00773	Etoposide	1	Completed	1
DB15030	GTI-2040	1	Completed	1
DB12047	Ganetespib	1	Completed	1
DB01177	Idarubicin	1	Completed	1
DB00619	Imatinib	1	Completed	1
DB00619	Imatinib	1	Terminated	1
DB06188	Ispinesib	1	Completed	1
DB14123	Menthol	1	Terminated	1
DB00331	Metformin	1	Terminated	1
DB12191	Obatoclax	1	Terminated	1
DB06641	Perifosine	1	Completed	1
DB14729	Rebeccamycin	1	Completed	1
DB06176	Romidepsin	1	Completed	1
DB11965	SJG-136	1	Terminated	1
DB00020	Sargramostim	1	Completed	1
DB11942	Selinexor	1	Active Not Recruiting	1
DB00398	Sorafenib	1	Terminated	1
DB06398	Tanespimycin	1	Completed	1
DB06287	Temsirolimus	1	Terminated	1
DB11940	Triapine	1	Completed	1
DB00541	Vincristine	1	Terminated	1
DB02546	Vorinostat	1	Completed	4
DB00041	Aldesleukin	1 / 2	Terminated	1
DB06616	Bosutinib	1 / 2	Recruiting	1
DB01008	Busulfan	1 / 2	Terminated	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Withdrawn	1
DB00091	Cyclosporine	1 / 2	Recruiting	1
DB00987	Cytarabine	1 / 2	Completed	1
DB00773	Etoposide	1 / 2	Terminated	1
DB01073	Fludarabine	1 / 2	Withdrawn	1
DB00619	Imatinib	1 / 2	Completed	2
DB00563	Methotrexate	1 / 2	Recruiting	1
DB00688	Mycophenolate mofetil	1 / 2	Recruiting	1
DB04868	Nilotinib	1 / 2	Completed	2
DB08901	Ponatinib	1 / 2	Recruiting	1
DB08877	Ruxolitinib	1 / 2	Completed	1
DB00864	Tacrolimus	1 / 2	Recruiting	1
DB17459	Therapeutic allogeneic lymphocytes	1 / 2	Terminated	1
DB02546	Vorinostat	1 / 2	Recruiting	1
DB02594	2'-Deoxycytidine	2	Completed	1
DB00437	Allopurinol	2	Terminated	1
DB09312	Antilymphocyte immunoglobulin (horse)	2	Completed	2
DB09312	Antilymphocyte immunoglobulin (horse)	2	Terminated	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	2
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Terminated	1
DB00394	Beclomethasone dipropionate	2	Completed	1
DB00112	Bevacizumab	2	Terminated	1
DB01008	Busulfan	2	Completed	3
DB01008	Busulfan	2	Terminated	1
DB00242	Cladribine	2	Withdrawn	1
DB09110	Coenzyme M	2	Withdrawn	1
DB00531	Cyclophosphamide	2	Completed	2
DB00531	Cyclophosphamide	2	Terminated	1
DB00531	Cyclophosphamide	2	Withdrawn	2
DB00091	Cyclosporine	2	Completed	2
DB00987	Cytarabine	2	Terminated	1
DB00987	Cytarabine	2	Withdrawn	2
DB01262	Decitabine	2	Completed	1
DB01609	Deferasirox	2	Terminated	1
DB01234	Dexamethasone	2	Withdrawn	1
DB00997	Doxorubicin	2	Withdrawn	1
DB00005	Etanercept	2	Completed	1
DB00099	Filgrastim	2	Withdrawn	1
DB01073	Fludarabine	2	Completed	5
DB01073	Fludarabine	2	Terminated	1
DB01073	Fludarabine	2	Withdrawn	1
DB01177	Idarubicin	2	Terminated	1
DB00619	Imatinib	2	Completed	1
DB00619	Imatinib	2	Withdrawn	1
DB00650	Leucovorin	2	Withdrawn	1
DB14123	Menthol	2	Completed	1
DB00563	Methotrexate	2	Completed	3
DB00563	Methotrexate	2	Withdrawn	1
DB00959	Methylprednisolone	2	Completed	2
DB14644	Methylprednisolone hemisuccinate	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	2
DB00688	Mycophenolate mofetil	2	Terminated	1
DB00688	Mycophenolate mofetil	2	Withdrawn	1
DB04868	Nilotinib	2	Withdrawn	1
DB00904	Ondansetron	2	Completed	1
DB00635	Prednisone	2	Withdrawn	1
DB00049	Rasburicase	2	Terminated	1
DB00073	Rituximab	2	Terminated	1
DB00073	Rituximab	2	Withdrawn	1
DB14546	Sulfate ion	2	Withdrawn	1
DB01268	Sunitinib	2	Terminated	1
DB00864	Tacrolimus	2	Completed	4
DB00864	Tacrolimus	2	Terminated	1
DB00864	Tacrolimus	2	Withdrawn	1
DB06287	Temsirolimus	2	Completed	1
DB17459	Therapeutic allogeneic lymphocytes	2	Completed	1
DB11678	Treosulfan	2	Completed	1
DB11940	Triapine	2	Completed	1
DB00541	Vincristine	2	Withdrawn	1
DB00091	Cyclosporine	Not Available	Completed	1
DB00099	Filgrastim	Not Available	Terminated	1
DB01073	Fludarabine	Not Available	Completed	1
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB14509	Lithium carbonate	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	Completed	1
DB00039	Palifermin	Not Available	Completed	1
DB06809	Plerixafor	Not Available	Terminated	1
DB01610	Valganciclovir	Not Available	Completed	1