maintenance therapy (DBCOND0021419)

Identifiers

Synonyms

Maintenance therapy (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alpha-1-proteinase inhibitor	A purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.	Neutrophil elastasetarget
Asenapine	An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.	5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Alpha-1A adrenergic receptortarget D(1A) dopamine receptortarget D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Histamine H1 receptortarget Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 5Atarget UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 3A4enzyme Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Albumincarrier alpha1-acid glycoproteincarrier
Avelumab	An anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.	Programmed cell death 1 ligand 1target
Budesonide	A corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Annexin A1target Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Corticosteroid-binding globulincarrier Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Albumincarrier
Carglumic acid	An analog of N-acetylglutamate (NAG) used for the treatment of acute and chronic hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency.	Carbamoyl-phosphate synthase [ammonia], mitochondrialtarget
Dupilumab	A monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.	Interleukin-4 receptor subunit alphatarget Interleukin-13target Interleukin-4target
Fluoxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.	Sodium-dependent serotonin transportertarget Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme CYP2B proteinenzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Potassium voltage-gated channel subfamily H member 2target 5-hydroxytryptamine receptor 2Ctarget Cyclin-dependent kinases regulatory subunit 1target Neuronal acetylcholine receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit beta-4target
Formoterol	An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-3 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2A6enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme Solute carrier family 22 member 1transporter Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 3transporter Albumincarrier UDP-glucuronosyltransferase 1A1enzyme
Human immunoglobulin G	A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders.	Low affinity immunoglobulin gamma Fc region receptor III-Btarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget High affinity immunoglobulin gamma Fc receptor Itarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget Putative high affinity immunoglobulin gamma Fc receptor IBtarget Complement C3target Complement C4-Atarget Complement C4-Btarget Complement C5target
Methadone	An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.	NMDA receptortarget Mu-type opioid receptortarget Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Delta-type opioid receptortarget Cytochrome P450 3A7enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C8enzyme Aromataseenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C9enzyme 5-hydroxytryptamine receptor 3Atarget Alpha-1-acid glycoprotein 1carrier Albumincarrier Neuronal acetylcholine receptor subunit alpha-7target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 2B4enzyme
Niraparib	A poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.	Poly [ADP-ribose] polymerase 1target Poly [ADP-ribose] polymerase 2target Carboxylesteraseenzyme Cytochrome P450 1A2enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Olaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.	Poly [ADP-ribose] polymerase 1target Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Poly [ADP-ribose] polymerase 2target Protein mono-ADP-ribosyltransferase PARP3target Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Aldo-keto reductase family 1 member C3target UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier
Reboxetine	A drug used for the acute treatment of major depression and for maintenance therapy of depression.	Sodium-dependent noradrenaline transportertarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter
Rucaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults.	Poly [ADP-ribose] polymerase 1target Poly [ADP-ribose] polymerase 2target Protein mono-ADP-ribosyltransferase PARP3target Cytochrome P450 2D6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Solute carrier family 22 member 1transporter ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 3A43enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme
Spironolactone	An aldosterone receptor antagonist used to treat edema, hypertension, heart failure, and aldosteronism.	Mineralocorticoid receptortarget Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Androgen receptortarget Progesterone receptortarget Glucocorticoid receptortarget Nuclear receptor subfamily 1 group I member 2target Bile salt export pumptransporter Albumincarrier alpha1-acid glycoproteincarrier Estrogen receptortarget Cytochrome P450 11B2, mitochondrialenzyme Voltage-dependent L-type calcium channeltarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05965284	Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM)	Azathioprine Telitacicept	treatment	4	recruiting
NCT03160105	Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV)	No drug interventions	treatment	4	completed
NCT06341556	A Multicenter, Prospective, Phase II Study of Zanubrutinib for Maintenance in Patients With Mantle Cell Lymphoma	Zanubrutinib	treatment	2	recruiting
NCT03384459	Maintenance Therapy of 308-nm Excimer Laser Therapy in Patients With Vitiligo	No drug interventions	treatment	Not Available	unknown_status
NCT03384342	Maintenance Therapy of Narrow-band UV-B Therapy in Patients With Vitiligo	No drug interventions	treatment	Not Available	unknown_status
NCT04737343	Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis	Azathioprine Leflunomide	treatment	Not Available	recruiting
NCT05869227	Maintenance Therapy With Toripalimab Combined With Capecitabine/Placebo for Recurrent and Metastatic Nasopharyngeal Carcinoma	No drug interventions	treatment	3	recruiting
NCT04552912	Physical Activity to Improve Patient Reported Outcomes for Adults With Acute Leukemia	No drug interventions	supportive_care	Not Available	completed
NCT06277050	Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma	Capecitabine Toripalimab	treatment	3	recruiting