| Acetaminophen | An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | |
| Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | |
| Butylscopolamine | An antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain. | |
| Chlorphenesin | A phenol ether used to treat painful muscular conditions. | |
| Cyclobenzaprine | A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. | |
| Drotaverine | A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. | |
| Etodolac | An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. | |
| Famotidine | A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. | |
| Fenyramidol | A muscle relaxant indicated in the symptomatic treatment of musculoskeletal pain and spasms. | No drug targets |
| Flurbiprofen | An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. | |
| Ibuprofen | An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | |
| Lorazepam | A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. | |
| Mephenoxalone | A muscle relaxant indicated in the treatment of painful muscle spasms and cramps. | No drug targets |
| Methocarbamol | A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. | |
| Naproxen | An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. | |
| Orphenadrine | A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. | |
| Ox bile extract | Not Annotated | No drug targets |
| Phenprobamate | A skeletal muscle relaxant indicated in the treatment of pain caused by muscle spasms. | No drug targets |
| Thiocolchicoside | A semi-synthetic colchicine derivative used as an analgesic and anti-inflammatory. | |