Metastatic Colorectal Cancer (CRC)
Also known as: Metastatic Colorectal Cancers / Metastatic Cancer Colorectal / Metastatic Colorectal Cancer / Colorectal Cancer Metastatic / Colorectal Cancer, Metastatic / Cancer - Metastatic Colorectal / Metastatic Colorectal Cancer (MCRC) / Metastatic Colo-rectal Cancer / MCRC / Metastasis from malignant neoplasm of colon and/or rectum (disorder) / Secondary malignant neoplasm of colon and/or rectum (disorder) / Secondary malignant neoplasm of large intestine (disorder)
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB08885 | Aflibercept | A vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy. |
| DB00112 | Bevacizumab | A monoclonal anti-vascular endothelial growth factor antibody used in combination with antineoplastic agents for the treatment of many types of cancer. |
| DB00002 | Cetuximab | An endothelial growth factor receptor binding fragment used to treat colorectal cancer as well as squamous cell carcinoma of the head and neck. |
| DB11718 | Encorafenib | A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations. |
| DB11596 | Levoleucovorin | A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. |
| DB09035 | Nivolumab | A PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma. |
| DB01269 | Panitumumab | A recombinant humanized monoclonal antibody used to treat EGFR-expressing, metastatic colorectal carcinoma that is refractory to fluoropyrimidine-, oxaliplatin-, and irinotecan- containing chemotherapy regimens. |
| DB05578 | Ramucirumab | An antineoplastic agent and direct VEGFR2 (vascular endothelial growth factor receptor 2) antagonist that blocks the binding of natural VEGF ligands, which are secreted by solid tumors to promote angiogenesis and enhance tumor blood supply. |
| DB08896 | Regorafenib | A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. |
| DB09343 | Tipiracil | A thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. |
| DB00432 | Trifluridine | A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. |