Malaria caused by Plasmodium falciparum (DBCOND0021343)

Identifiers

Synonyms

Falciparum; Malaria / Malaria Falciparum / Malaria, Falciparum / Malaria,Falciparum / Falciparum Malaria / Malaria caused by plasmodium falciparum / Plasmodium falciparum malaria, unspecified / Falciparum malaria (disorder) / Falciparum malaria (malignant tertian) / Plasmodium falciparum malaria / Malignant tertian fever (finding) / Plasmodium falciparum infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Artemisinin	A medication indicated in the treatment of malaria.	Cytochrome P450 2B6enzyme Dihydroorotate dehydrogenase (quinone), mitochondrialtarget
Artenimol	For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941.	Actin, cytoplasmic 2target Alpha-aminoadipic semialdehyde dehydrogenasetarget Annexin A2target ATP synthase subunit alpha, mitochondrialtarget ATP synthase subunit g, mitochondrialtarget ATP synthase subunit O, mitochondrialtarget Calpastatintarget T-complex protein 1 subunit gammatarget Cofilin-1target Chloride intracellular channel protein 1target Cysteine and glycine-rich protein 1target Dihydropyrimidinase-related protein 2target Desmoplakintarget Elongation factor 1-alpha 1target Alpha-enolasetarget Filamin-Atarget Alpha-ketoglutarate-dependent dioxygenase FTOtarget Glucose-6-phosphate 1-dehydrogenasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Glucose-6-phosphate isomerasetarget Heterogeneous nuclear ribonucleoproteins A2/B1target Heterogeneous nuclear ribonucleoprotein D0target Heterogeneous nuclear ribonucleoprotein Ktarget Heterochromatin protein 1-binding protein 3target Heat shock protein beta-1target Ras GTPase-activating-like protein IQGAP1target Far upstream element-binding protein 2target L-lactate dehydrogenase A chaintarget L-lactate dehydrogenase B chaintarget Galectin-1target Microtubule-associated protein 4target Malate dehydrogenase, cytoplasmictarget Puromycin-sensitive aminopeptidasetarget Profilin-1target Phosphoglycerate kinase 1target Pyruvate kinase PKMtarget Peptidyl-prolyl cis-trans isomerase Atarget Peroxiredoxin-1target Large ribosomal subunit protein uL16target Large ribosomal subunit protein eL14target Large ribosomal subunit protein eL18target Large ribosomal subunit protein uL23target Large ribosomal subunit protein uL29target Large ribosomal subunit protein uL4target Small ribosomal subunit protein uS15target Small ribosomal subunit protein eS17target Small ribosomal subunit protein uS13target Small ribosomal subunit protein eS19target Small ribosomal subunit protein eS28target Small ribosomal subunit protein uS7target Small ribosomal subunit protein eS6target Small ribosomal subunit protein eS8target Small ribosomal subunit protein uS4target Splicing factor 1target Splicing factor, proline- and glutamine-richtarget Small nuclear ribonucleoprotein Sm D2target Signal recognition particle 14 kDa proteintarget Serine/arginine-rich splicing factor 4target Transgelintarget Transgelin-2target Triosephosphate isomerasetarget Tropomyosin alpha-1 chaintarget Tubulin alpha-1A chaintarget Vimentintarget Zyxintarget Heat shock cognate 71 kDa proteintarget Tubulin beta-6 chaintarget Tubulin beta-4A chaintarget Tubulin beta chaintarget Fructose-bisphosphate aldolase Atarget Glyceraldehyde-3-phosphate dehydrogenasetarget Cytochrome ctarget Phosphoglycerate mutase 1target Myosin-9target Protein disulfide-isomerasetarget Probable ATP-dependent RNA helicase DDX5target Serine hydroxymethyltransferase, mitochondrialtarget Spliceosome RNA helicase DDX39Btarget Nucleophosmintarget Translationally-controlled tumor protein homologtarget P-type Ca2+-transporting ATPasetarget Ornithine aminotransferasetarget Elongation factor 1-alphatarget Multidrug resistance proteintarget Elongation factor 2target Actin-1target Glyceraldehyde-3-phosphate dehydrogenasetarget Fructose-bisphosphate aldolasetarget Cell division cycle protein 48 homologue,putativetarget Heat shock protein 90target Eukaryotic initiation factor 4Atarget Pyruvate kinasetarget L-lactate dehydrogenasetarget Protein disulfide-isomerasetarget Thioredoxin-related protein, putativetarget Spermidine synthasetarget Probable ATP-dependent 6-phosphofructokinasetarget Glutamate dehydrogenasetarget Endoplasmin homolog, putativetarget Hypoxanthine-guanine-xanthine phosphoribosyltransferasetarget Enolasetarget 40S ribosomal protein S3target Non-SERCA-type Ca2+-transporting P-ATPasetarget Tubulin alpha chaintarget Knob-associated histidine-rich proteintarget S-adenosylmethionine synthasetarget V-type H(+)-translocating pyrophosphatase, putativetarget 60S ribosomal protein L4target Phosphoethanolamine N-methyltransferasetarget 40S ribosomal protein S3atarget Conserved Plasmodium membrane proteintarget 60S ribosomal protein L3target High molecular weight rhoptry protein 2target Serine repeat antigen 5target 40S ribosomal protein S19target Glycophorin-binding proteintarget Calcium-transporting ATPasetarget V-type proton ATPase catalytic subunit Atarget 60S ribosomal protein L2target Acyl-CoA synthetasetarget Plasmepsin IVtarget Plasmepsin-1target Chloroquine resistance transportertarget 14-3-3 proteintarget Isoleucine--tRNA ligase, putativetarget Plasmodium exported proteintarget Tubulin beta chaintarget 60S ribosomal protein L27target Sec62, putativetarget Autophagy-related protein 18, putativetarget Mature parasite-infected erythrocyte surface antigentarget Importin-7, putativetarget Importin subunit alphatarget Peptidyl-prolyl cis-trans isomerasetarget DnaJ protein, putativetarget Merozoite surface protein 1target Glutamate--tRNA ligasetarget T-complex protein 1 subunit etatarget Plasmepsin-2target Chaperone, putativetarget Rhoptry neck protein 3target 40S ribosomal protein S5, putativetarget Skeleton-binding protein 1target Purine nucleotide phosphorylase, putativetarget Adenosylhomocysteinasetarget Adenosine deaminasetarget Methionine--tRNA ligasetarget Carbamoyl phosphate synthetasetarget Aspartate carbamoyltransferasetarget Signal recognition particle receptor, beta subunittarget Parasite-infected erythrocyte surface proteintarget Coatomer alpha subunit, putativetarget Hexokinasetarget Proteasome subunit alpha typetarget Haloacid dehalogenase-like hydrolasetarget Insulinase, putativetarget 40S ribosomal protein S21target Ubiquitin-conjugating enzyme E2target Eukaryotic translation initiation factor 3 subunit Ctarget 60S ribosomal protein L24, putativetarget 60S ribosomal protein L23target 60S ribosomal protein L17, putativetarget HAP proteintarget Heat shock protein 110, putativetarget 60S ribosomal protein L10, putativetarget Lysophospholipase, putativetarget Polyadenylate-binding proteintarget Ubiquitin-60S ribosomal protein L40target Phosphoribosylpyrophosphate synthetasetarget Thioredoxin peroxidase 1target Protein transport protein SEC31target Dipeptidyl aminopeptidase 1target Ring-infected erythrocyte surface antigentarget ATP-dependent RNA helicase UAP56target Calcium-dependent protein kinase 4target GTP-binding nuclear protein Rantarget Nucleoside transporter 2target Anamorsin homologtarget Glutamine synthetase, putativetarget 60S ribosomal protein L30e, putativetarget Casein kinase 2, alpha subunittarget Threonine--tRNA ligasetarget cAMP-dependent protein kinase regulatory subunittarget Elongation factor 1-gamma, putativetarget Thioredoxin-like proteintarget 60S ribosomal protein L21target 60S ribosomal protein L14, putativetarget Inner membrane complex sub-compartment protein 3target HSP40, subfamily A, putativetarget Pyridoxal 5'-phosphate synthase subunit Pdx1target UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme Albumintarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme
Atovaquone	An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.	Dihydroorotate dehydrogenase (quinone), mitochondrialtarget Dihydroorotate dehydrogenase (quinone), mitochondrialtarget Cytochrome btarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter
Clindamycin	A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier ATP-dependent translocase ABCB1transporter 50S ribosomal protein L1target
Doxycycline	A tetracycline antibiotic used to treat a wide variety of bacterial infections.	Solute carrier family 22 member 6transporter Cytochrome P450 3A4enzyme ATP-binding cassette sub-family B member 5transporter Albumincarrier 30S ribosomal proteintarget
Mefloquine	An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax.	Cholinesteraseenzyme Cytochrome P450 3A4enzyme Adenosine receptor A2atarget Fe(II)-protoporphyrin IXtarget ATP-dependent translocase ABCB1transporter Aromataseenzyme Acetylcholinesteraseenzyme 80S ribosomal subunittarget
Piperaquine	For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638.	Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2E1enzyme
Proguanil	A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.	Bifunctional dihydrofolate reductase-thymidylate synthasetarget Dihydrofolate reductasetarget Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Peptide deformylase, mitochondrialtarget
Quinidine	A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.	Sodium channel protein type 5 subunit alphatarget Alpha-1-acid glycoprotein 1carrier Potassium voltage-gated channel subfamily H member 2target Potassium channel subfamily K member 1target Potassium channel subfamily K member 6target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Bile salt export pumptransporter Cytochrome P450 2C8enzyme Albumincarrier
Sulfadiazine	A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.	Cytochrome P450 2C9enzyme Dihydropteroate synthetasetarget Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Dihydropteroate synthasetarget
Sulfadoxine	A long acting sulfonamide used for the treatment or prevention of malaria.	Dihydropteroate synthetasetarget Bifunctional dihydrofolate reductase-thymidylate synthasetarget Dihydropteroate synthasetarget Amine oxidase [flavin-containing] Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06347471	The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy	Artemether Artenimol Lumefantrine Lumefantrine co-artemether Piperaquine	treatment	4	recruiting
NCT00928083	A Study to Investigate the Safety, Tolerability and Pharmacokinetics of OZ439 in Healthy Male and Female Subjects	Artefenomel	treatment	1	completed
NCT00164216	Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru	Artesunate Mefloquine	Not Available	Not Available	completed
NCT04565184	Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde	Amodiaquine Artemether Artesunate Lumefantrine Lumefantrine co-artemether	treatment	4	completed
NCT04079621	Short Course Radical Cure of P. Vivax Malaria in Nepal	Primaquine	treatment	4	completed
NCT03947190	A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults	Matrix-M	treatment	2	unknown_status
NCT05604521	A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI	No drug interventions	prevention	1	terminated
NCT03355664	Study to Compare the Triple ACT AL+AQ With the ACT AL in Cambodia and Vietnam	No drug interventions	treatment	3	completed
NCT02084602	Assessment of Artesunate/Mefloquine in the Peruvian Amazon	Artesunate Mefloquine	treatment	4	completed
NCT06036030	Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua	Artenimol Piperaquine Primaquine	treatment	2	completed
NCT05958693	TES of Artemether-lumefantrine for Pf in the Philippines in 2015	Artemether Lumefantrine Lumefantrine co-artemether Primaquine	Not Available	Not Available	completed
NCT05287893	Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria	Pyronaridine	other	1	completed
NCT05060198	Therapeutic Efficacy Study of AL and DP in Western Kenya	Artemether Artenimol Lumefantrine Lumefantrine co-artemether Piperaquine	treatment	Not Available	completed
NCT04969185	Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention	No drug interventions	Not Available	Not Available	completed
NCT04858087	Malawi International Center of Excellence in Malaria Research School-based Cohort	No drug interventions	Not Available	Not Available	completed
NCT06337253	Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique	Amodiaquine Pyrimethamine Sulfadoxine	prevention	4	not_yet_recruiting
NCT03882528	Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54	No drug interventions	screening	1	completed
NCT03580824	A Study to Determine if a New Malaria Vaccine is Safe and Induces Immunity Among Kenyan Adults, Young Children and Infants	Matrix-M	treatment	1 / 2	completed
NCT03195387	Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model	No drug interventions	prevention	1	withdrawn
NCT05567016	CHILD (Child Health and Infection With Low Density) Malaria	No drug interventions	prevention	Not Available	active_not_recruiting
NCT05244954	Comparing Chemoprevention Approaches for School-based Malaria Control	Artenimol Chloroquine Piperaquine	prevention	4	completed
NCT05252845	Safety and Immunogenicity of the Malaria Vaccine, R21/MatrixM, in Healthy Thai Adults	Matrix-M	prevention	2	completed
NCT05685875	Association of Diabetes and Metabolic Syndrome With Severe Malaria in Cameroon	No drug interventions	Not Available	Not Available	recruiting
NCT04310085	Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites	Artemether Lumefantrine Lumefantrine co-artemether	treatment	1	completed
NCT03138096	Safety and Protective Efficacy of Pb(PfCS@UIS4)	No drug interventions	prevention	1 / 2	completed
NCT02987270	Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya	Artenimol Piperaquine	treatment	3	completed
NCT04271306	Safety, Immunogenicity and ex Vivo Efficacy of Pfs25-IMX313/Matrix-M in Healthy Volunteers in Bagamoyo, Tanzania.	Matrix-M	treatment	1	unknown_status
NCT04251351	Effect of Paracetamol on Kidney Function in Severe Malaria	Acetaminophen	prevention	3	recruiting
NCT00677833	Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa	Artemether Azithromycin Chloroquine Lumefantrine	treatment	2 / 3	completed
NCT00137553	The Efficacy of Re-treatment With Sulfadoxine-pyrimethamine in Children	Pyrimethamine Sulfadoxine	treatment	4	completed
NCT01163877	Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma	No drug interventions	basic_science	Not Available	completed
NCT02448745	Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)	No drug interventions	prevention	Not Available	completed
NCT00374998	Safety and Immunogenicity Study of the Malaria Vaccines FP9 PP and MVA PP	No drug interventions	prevention	1	completed
NCT00509015	Mass-Drug Administration to Reduce Malaria Transmission	Artesunate Primaquine Pyrimethamine Sulfadoxine	prevention	Not Available	completed
NCT02434952	Safety and Tolerability of Low Dose Primaquine	Artenimol Piperaquine Primaquine	treatment	4	completed
NCT00164359	Amodiaquine Plus Artesunate Versus Lapdap Plus Artesunate in the Treatment of Uncomplicated P. Falciparum Malaria in Malawi	Amodiaquine Artesunate Chlorproguanil Dapsone	treatment	4	completed
NCT00126906	Prevention of Malaria During Pregnancy Using Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: Malawi	Pyrimethamine Sulfadoxine	educational_counseling_training	Not Available	completed
NCT00344006	Chlorproguanil-Dapsone-Artesunate Versus COARTEM For Uncomplicated Malaria	Artemether Artesunate Chlorproguanil Dapsone Lumefantrine	treatment	3	completed
NCT01713517	Impact of Insecticide Resistance on Vector Control	No drug interventions	prevention	4	unknown_status
NCT00371735	Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria	Artesunate Chlorproguanil Dapsone	treatment	3	completed
NCT00082563	Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum	Azithromycin Chloroquine	treatment	2	terminated
NCT00426439	Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau	Artemether Chloroquine L-Acetylleucine Lumefantrine Lumefantrine co-artemether	treatment	4	completed
NCT01108939	Study of Iron Absorption and Utilization in Asymptomatic Malaria	No drug interventions	treatment	0	completed
NCT01103830	Safety Study on the Effect of Eurartesim™ on QT/QTc Interval Compared to Riamet in Healthy Volunteers	Artemether Artenimol Lumefantrine Lumefantrine co-artemether Piperaquine	treatment	1	completed
NCT06524336	Host Immune Dynamics Following Seasonal Malaria Chemoprevention in African Children	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06424002	The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children	Artemether Lumefantrine	prevention	4	not_yet_recruiting
NCT06141057	A Study to Compare Two Dosing Regimens for a New Malaria Vaccine	Matrix-M	treatment	1	recruiting
NCT06083688	Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi	Amodiaquine Artenimol Chloroquine Hydroxychloroquine Piperaquine Pyrimethamine Sulfadoxine Trimethoprim	prevention	4	not_yet_recruiting
NCT05979207	Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum	No drug interventions	treatment	1	completed
NCT05978037	A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines	Matrix-M	prevention	1 / 2	recruiting
NCT05980156	Comparing Chemoprevention Drugs for School-based Malaria Control	Artenimol Chloroquine Hydroxychloroquine Piperaquine Pyrimethamine Sulfadoxine Trimethoprim	prevention	4	completed
NCT05958810	TES of Artemether-lumefantrine for Pf in the Philippines in 2017-2018	Artemether Lumefantrine Lumefantrine co-artemether Primaquine	Not Available	Not Available	completed
NCT05801198	Addressing Asymptomatic Plasmodium Reservoirs to Accelerate Malaria Elimination and Eradication in Rwanda.	No drug interventions	treatment	2	not_yet_recruiting
NCT05507970	First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367	No drug interventions	treatment	1	completed
NCT05468606	Coadministration of GA2 Sporozoites With Adjuvants	Imiquimod Yellow fever vaccine	prevention	0	recruiting
NCT05081089	Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali	Amodiaquine Artemether Lumefantrine Lumefantrine co-artemether Primaquine Pyrimethamine Sulfadoxine Tafenoquine	treatment	2	completed
NCT05058885	Plasmodium Vivax Among Duffy Negative Population in Cameroon.	No drug interventions	Not Available	Not Available	recruiting
NCT04864444	Mass Drug Administration of Dihydroartemisinin-piperaquine + Single Low-dose Primaquine to Accelerate Toward Elimination Activities	Artenimol Piperaquine Primaquine	prevention	Not Available	completed
NCT04844905	Adjunctive Ivermectin Mass Drug Administration for Malaria Control	Artenimol Ivermectin Piperaquine	treatment	3	unknown_status
NCT04318002	Safety and Immunogenicity of RH5.1/Matrix-M in Adults and Infants Living in Tanzania	Matrix-M	prevention	1	active_not_recruiting
NCT04289688	Health Itinerary of Young Children With Suspected Bloodstream Infection in Kisantu General Referral Hospital, DR Congo	No drug interventions	Not Available	Not Available	completed
NCT04149106	Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin	Artenimol Pyrimethamine Sulfadoxine	prevention	3	active_not_recruiting
NCT03640403	Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania	Amodiaquine Artenimol Artesunate Piperaquine	prevention	3	unknown_status
NCT03511443	Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections	No drug interventions	diagnostic	Not Available	unknown_status
NCT03201770	Cohort Event Monitoring Study of Pyramax®	Artesunate Pyronaridine	treatment	4	completed
NCT05125133	Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.	No drug interventions	prevention	Not Available	unknown_status
NCT05135273	Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali	Matrix-M Rabies virus inactivated antigen, A	prevention	1	completed
NCT05197751	MSP3-CRM-Vac4All/ Alhydrogel® Malaria Vaccine	No drug interventions	prevention	1	active_not_recruiting
NCT05550909	Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali	Amodiaquine Artemether Artesunate Lumefantrine Lumefantrine co-artemether Primaquine	treatment	2	completed
NCT05676645	Pharmacokinetics of Antimalarials in Breastfeeding Ugandan Mother-infant Pairs	Artemether Lumefantrine	Not Available	Not Available	active_not_recruiting
NCT05757167	Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics	Artemether Lumefantrine Lumefantrine co-artemether	screening	4	recruiting
NCT03178643	Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)	Amodiaquine Artenimol Piperaquine Proguanil Sulfadoxine	prevention	4	completed
NCT03435874	Safety and Immunogenicity of ChAd63 RH5 and MVA RH5 in Adults, Young Children and Infants Living in Tanzania	Rabies virus inactivated antigen, A	prevention	1	completed
NCT03420053	Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults	No drug interventions	prevention	1	completed
NCT03241901	"Prolonging the Therapeutic Life Span of Artemisinin-based Combination Therapies (ACT) in Bagamoyo District, Tanzania"	Artemether Lumefantrine Primaquine	treatment	4	completed
NCT01992900	A Pharmacokinetic/Pharmacodynamic Study of Eurartesim Dispersible Formulation in Infants With P.Falciparum Malaria	Artenimol Piperaquine	treatment	2	completed
NCT01325974	Time to Become Negative of Three Rapid Diagnostic Tests for Malaria	No drug interventions	Not Available	Not Available	completed
NCT00084227	Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America	Atovaquone Azithromycin Chloroquine Proguanil	treatment	2 / 3	completed
NCT01160562	Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity	No drug interventions	Not Available	Not Available	completed
NCT02325180	Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia	Artemether Artenimol Lumefantrine Lumefantrine co-artemether Piperaquine	treatment	4	completed
NCT01944189	Artemether/ Lumefantrine: A Study of the Effect of Local Food on Pharmacokinetics and Population Pharmacokinetics	No drug interventions	supportive_care	4	unknown_status
NCT01783340	Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis	Azithromycin	prevention	1 / 2	withdrawn
NCT00084240	Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia	Azithromycin Chloroquine Pyrimethamine Sulfadoxine	treatment	2 / 3	terminated
NCT02329301	Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia	Artenimol Dihydroxyacetone phosphate Piperaquine	treatment	Not Available	completed
NCT00152204	The Community Effectiveness of IPTi in Southern Tanzania	Pyrimethamine Sulfadoxine	prevention	3	unknown_status
NCT01442168	Sevuparin/DF02 as an Adjunctive Therapy in Subjects Affected With Uncomplicated Falciparum Malaria	Atovaquone	treatment	1 / 2	terminated
NCT00147368	Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria	Arginine	treatment	1 / 2	completed
NCT00142246	Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education.	Amodiaquine	prevention	3	completed
NCT00223990	Double-blind, Randomized, Controlled Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria Vaccine	Rabies immune globulin, human Rabies virus inactivated antigen, A	prevention	2	completed
NCT00885287	Interactions Between Artemether-lumefantrine and Antiretrovirals in HIV-patients With Uncomplicated Malaria in Tanzania	Artemether Lumefantrine	treatment	4	completed
NCT01660854	Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites	Atovaquone Proguanil	basic_science	Not Available	completed
NCT01326754	Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi	Amodiaquine Artemether Artenimol Artesunate Lumefantrine Piperaquine	treatment	Not Available	completed
NCT01556945	Safety and Preliminary Efficacy of the Malaria Vaccine Candidates Falciparum Merozoite Protein-1 (FMP1) and SmithKlineBeecham (SKBB) Candidate Malaria Vaccine RTS,S	No drug interventions	prevention	1 / 2	completed
NCT04609098	Single Low Dose Tafenoquine to Reduce P. Falciparum Transmission in Mali (NECTAR2)	Artenimol Piperaquine Tafenoquine	treatment	2	completed
NCT00374205	Randomized Trial on Effectiveness of ACTs in Ghana	Amodiaquine Artemether Artesunate Lumefantrine Lumefantrine co-artemether	treatment	4	terminated
NCT02637128	In Vivo Efficacy of Artemether-Lumefantrine and Artesunate-Amodiaquine for Uncomplicated P. Falciparum Malaria	Amodiaquine Artemether Artesunate Lumefantrine Lumefantrine co-artemether	treatment	4	completed
NCT00375128	Sporozoite Challenge of Polyprotein Vaccinees	No drug interventions	prevention	1 / 2	completed
NCT01204411	Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010	Amodiaquine Artesunate	treatment	4	withdrawn
NCT05385471	A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults	Matrix-M	prevention	0	recruiting
NCT02737007	A Microdose Study in Healthy Subjects to Describe Intravenous Pharmacokinetics of GSK3191607	No drug interventions	treatment	1	completed
NCT00142207	Preventing Malaria During Pregnancy in Epidemic-prone Areas.	Pyrimethamine Sulfadoxine	prevention	3	completed
NCT00157885	A Randomised Trial of Artekin and Artesunate & Amodiaquine for Uncomplicated Malaria in Timika, Papua, Indonesia.	Amodiaquine Artesunate	treatment	Not Available	completed
NCT01829737	Malaria Transmission Studies in Mali	No drug interventions	Not Available	Not Available	completed
NCT04839900	Proactive Community Case Management for Malaria in Zambia	No drug interventions	treatment	Not Available	completed
NCT00951106	Therapeutic Efficacy Study of Pyrimethamine/Sulfdoxine (Fansidar®) for the Treatment of Uncomplicated Falciparum Malaria in the Peruvian Amazon	Pyrimethamine Sulfadoxine	treatment	Not Available	completed
NCT00479206	Artemisinin Resistance in Cambodia	Artesunate	treatment	Not Available	completed
NCT01222949	A Pharmacokinetic (PK) Trial in Healthy Asian and Caucasian Volunteers Investigating the PK Profile of Eurartesim™	Artenimol Piperaquine	treatment	1	completed
NCT06572644	Performance of an Ultrasensible Malaria Rapid Diagnostic Test Among Pregnant Women in Burkina Faso	No drug interventions	Not Available	Not Available	completed
NCT06558643	Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants	No drug interventions	treatment	1	not_yet_recruiting
NCT06413108	Safety, Pharmacokinetics, and Plasmodium Falciparum Transmission-reducing Activity of Monoclonal Antibody TB31F in Mali	No drug interventions	other	1 / 2	recruiting
NCT05790889	A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.	Matrix-M Rabies virus inactivated antigen, A	prevention	1 / 2	recruiting
NCT05776017	MSP3-CRM-Vac4All/ Alhydrogel® Vaccine	Rabies virus inactivated antigen, A	prevention	1 / 2	recruiting
NCT05306067	Plasmodium Falciparum Genomic Intelligence in Mozambique	No drug interventions	Not Available	Not Available	completed
NCT05150808	Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania	No drug interventions	prevention	3	unknown_status
NCT04940130	PfSPZ Vaccine Trial in Malian Children	No drug interventions	prevention	2	completed
NCT04862416	Safety and Efficacy of R0.6C Vaccine	No drug interventions	prevention	1	completed
NCT04800055	Attractive Targeted Sugar Bait Phase III Trial in Zambia	No drug interventions	prevention	Not Available	active_not_recruiting
NCT04473768	Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children	No drug interventions	Not Available	Not Available	completed
NCT04319380	Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study	No drug interventions	prevention	3	completed
NCT06320535	A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™	Matrix-M	prevention	1	recruiting
NCT04238689	Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F	No drug interventions	prevention	1	completed
NCT04130282	VAC077: Safety and Immunogenicity of the Pfs25-IMX313/Matrix-M Vaccine	Matrix-M	prevention	1	terminated
NCT04049916	Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission	Artenimol Artesunate Piperaquine Primaquine Pyronaridine	treatment	2 / 3	completed
NCT03896724	Safety, Immunogenicity and Efficacy of R21 Matrix-M in 5-17 Month Old Children in Nanoro, Burkina Faso	Matrix-M Rabies virus inactivated antigen, A	treatment	1 / 2	completed
NCT03813108	Safety and Efficacy of NF135 CPS Immunization	Artemether Atovaquone Lumefantrine Mefloquine Proguanil	prevention	Not Available	terminated
NCT03806465	Malaria Vaccine Pilot Evaluation	No drug interventions	Not Available	Not Available	unknown_status
NCT03814616	Pyramax in Asymptomatic Carriers of P. Falciparum Monoinfections	Artesunate Pyronaridine	treatment	2	unknown_status
NCT03176719	Non-specific Effects of Vaccination on Mortality and Morbidity	No drug interventions	Not Available	Not Available	unknown_status
NCT05878366	Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC)	No drug interventions	other	Not Available	recruiting
NCT06293339	Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)	No drug interventions	prevention	1	not_yet_recruiting
NCT03143218	Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)	Rabies immune globulin, human	prevention	3	completed
NCT03454048	Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2	Atovaquone Piperaquine Proguanil Pyrimethamine Sulfadoxine	other	Not Available	completed
NCT03867331	To Assess the Safety, Immunogenicity and Efficacy of VLPM01 in Healthy, Malaria-Naïve Volunteers	No drug interventions	prevention	1	completed
NCT00378625	Efficacy, Effect on Gametocytes and Tolerability of the Addition of Artesunate to Amodiaquine in Colombia	Artesunate	Not Available	3	completed
NCT04280692	Controlled Human Malaria Infection Transmission Model - Phase A	Artemether Lumefantrine Lumefantrine co-artemether Piperaquine Primaquine Pyrimethamine Sulfadoxine	basic_science	1 / 2	suspended
NCT06171113	A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants	No drug interventions	treatment	1	recruiting
NCT02389439	Efficacy and Safety of Pyronaridine-artesunate for the Treatment in Uncomplicated Falciparum Malaria	Artesunate Pyronaridine	treatment	2	completed
NCT01213966	Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infection	Artefenomel	treatment	2	completed
NCT01930331	Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO	Artemisinin Artenimol Naphthoquine Piperaquine	treatment	4	completed
NCT02014727	Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults	G100	treatment	1	completed
NCT00082576	Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa	Azithromycin Chloroquine Mefloquine	treatment	2 / 3	completed
NCT01222962	Food Interaction Study on the Pharmacokinetics of Eurartesim™ (DHA and PQP)in Healthy Male Adult Volunteers	Artenimol Piperaquine	treatment	1	completed
NCT04709692	Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malaria	SJ-733	treatment	2	completed
NCT02281344	MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants	No drug interventions	basic_science	1	terminated
NCT00529867	Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria	Artemether Lumefantrine Lumefantrine co-artemether	treatment	4	completed
NCT00408668	Efficacy of Combined PEV3A Virosomal Vaccine and FP9-MVA ME-TRAP Prime Boost Regimen	PEV3A	prevention	1 / 2	completed
NCT00164710	Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi	Amodiaquine Artemether Artesunate Chlorproguanil Dapsone Lumefantrine Pyrimethamine Sulfadoxine	treatment	4	completed
NCT00137514	Chloroquine and Amodiaquine for Treatment of Malaria in Children	Amodiaquine Chloroquine	treatment	4	completed
NCT01567423	Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria	Amodiaquine Artesunate Lumefantrine Lumefantrine co-artemether	treatment	Not Available	completed
NCT01019408	Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan	Chloroquine	treatment	4	completed
NCT02453308	A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC)	No drug interventions	treatment	2 / 3	completed
NCT02851108	Methylene Blue Against Falciparum Malaria in Burkina Faso	Chloride ion Methylene blue Primaquine	treatment	2	completed
NCT00149383	Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria	Rosiglitazone	treatment	1 / 2	completed
NCT00859807	A Bioequivalence Study Comparing Camoquin® Suspension (Pfizer) To Flavoquine® Tablets (Sanofi Aventis) In Healthy Subjects	Amodiaquine	treatment	4	completed
NCT01350856	Tracking Resistance to Artemisinin (TRAC)	Artesunate	treatment	4	completed
NCT04422015	Biological Mechanisms in Afebrile P. Falciparum Malaria	No drug interventions	Not Available	Not Available	completed
NCT00440752	The Impact of Artemether-Lumefantrine on Genes Associated With Antimalarial Resistance	No drug interventions	Not Available	Not Available	completed
NCT00157859	To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia	Chloroquine Pyrimethamine Sulfadoxine	treatment	Not Available	completed
NCT01047436	Efficacy of ArTiMist™ in Children	Artemether Quinine	treatment	2	completed
NCT00282919	A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria	Azithromycin Chloroquine	treatment	2	completed
NCT04289558	Nitrite Infusion in Children With Malaria	Nitrous acid	treatment	1	withdrawn
NCT00493363	Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia	Artesunate Mefloquine	treatment	Not Available	completed
NCT00158548	ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan	Amodiaquine Artesunate Chloroquine Primaquine	treatment	3	completed
NCT00894660	A Bioequivalence Study Comparing Amodiaquine Tablet (Pfizer) To Amodiaquine Tablets (Arsuamoon-Guilin China) In Healthy Subjects	Amodiaquine	basic_science	1	completed
NCT00513669	Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania	No drug interventions	prevention	1	completed
NCT04829695	Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon	Amodiaquine Artemether Artesunate Lumefantrine Lumefantrine co-artemether	treatment	4	unknown_status
NCT03916003	Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas	Primaquine	treatment	4	completed
NCT01144702	Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum	Artesunate Mefloquine	treatment	2 / 3	completed
NCT00157833	A Randomized Trial of Coartemether and Artekin for the Treatment of Uncomplicated Malaria in Papua, Indonesia.	No drug interventions	treatment	Not Available	completed
NCT00442377	Study to Investigate the Induction of an Protective Immune Response to Malaria	No drug interventions	prevention	Not Available	completed
NCT01365598	Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda	Primaquine	prevention	3	completed
NCT05911828	A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers	ZY19489	treatment	1	not_yet_recruiting
NCT04222088	TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014	Chloroquine Lumefantrine Lumefantrine co-artemether Primaquine	Not Available	Not Available	completed
NCT00459615	Phase II Dose Ranging Study of Artesunate	Artesunate	treatment	2	completed
NCT06529237	Malaria Molecular Surveillance in Mozambique (Phase 2)	No drug interventions	Not Available	Not Available	recruiting
NCT01115439	Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria	Artesunate Pyrimethamine Sulfadoxine	Not Available	Not Available	completed
NCT01374126	Azithromycin Combination Therapy for the Treatment of Severe Malaria	Artesunate Azithromycin	treatment	2	completed
NCT00894374	Bioequivalence Study Comparing Artesunate Tablet To Arsuamoon® Tablets (Guilin-China) In Healthy Subjects	Artesunate	basic_science	1	completed
NCT00403260	Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients	Artesunate Mefloquine Pyronaridine	treatment	3	completed
NCT00400101	Phase Ia Malaria Vaccine Trial of Two Virosome-Formulated Peptides	No drug interventions	prevention	1	terminated
NCT00722150	Artemisinin Resistance in Cambodia II	Artesunate	treatment	Not Available	completed