Showing BioInteractions for Acyclovir (DB00787)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Acyclovir is a DNA polymerase catalytic subunit inhibitor
1	DNA polymerase catalytic subunit inhibitors	Famciclovir, Foscarnet, Ganciclovir, Penciclovir, Valaciclovir, Vidarabine
2	DNA polymerase catalytic subunit activators	Talimogene laherparepvec

	Interacting Group	Interacting Drugs
	Acyclovir is a DNA polymerase catalytic subunit inhibitor
1	DNA polymerase catalytic subunit activators	Talimogene laherparepvec

	Interacting Group	Interacting Drugs
	Acyclovir is a Thymidine kinase potentiator
1	Thymidine kinase inducers	Ganciclovir

	Interacting Group	Interacting Drugs
	Acyclovir is a Thymidine kinase substrate
1	Thymidine kinase substrates	Valaciclovir
2	Thymidine kinase inducers	Vidarabine

	Interacting Group	Interacting Drugs
	Acyclovir is a Guanylate kinase substrate
1	Guanylate kinase substrates	Valaciclovir

	Interacting Group	Interacting Drugs
	Acyclovir is a Nucleoside diphosphokinase substrate
1	Nucleoside diphosphokinase substrates	Decitabine, Tenofovir disoproxil

	Interacting Group	Interacting Drugs
	Acyclovir is a Pyruvate Kinases substrate

	Interacting Group	Interacting Drugs
	Acyclovir is a Creatine Kinases substrate
1	Creatine Kinases substrates	Tenofovir disoproxil
2	Creatine Kinases inducers	Tenofovir disoproxil

	Interacting Group	Interacting Drugs
	Acyclovir is a Phosphoglycerate Kinases substrate

	Interacting Group	Interacting Drugs
	Acyclovir is a Succinyl-CoA Synthetases substrate

	Interacting Group	Interacting Drugs
	Acyclovir is a Phosphoenolpyruvate Carboxykinases substrate

	Interacting Group	Interacting Drugs
	Acyclovir is a Adenylosuccinate Synthetases substrate
1	Adenylosuccinate Synthetases substrates	Aspartic acid

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 1 substrate
1	Solute carrier family 22 member 1 substrates	Acetylcholine, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Formoterol, Ganciclovir, Guanfacine, Imatinib, Lamivudine, Lamotrigine, Metformin, Nafamostat, Nintedanib, Norepinephrine, Pancuronium, Phenformin, Pramipexole, Prazosin, Quinine, Ranitidine, Rocuronium, Salmeterol, Spermidine, Spermine, Sulpiride, Thiamine, Tubocurarine
2	Solute carrier family 22 member 1 inhibitors	Amantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Ganciclovir, Gilteritinib, Guanfacine, Guanidine, Indinavir, Lasmiditan, Levofloxacin, Linagliptin, Lurbinectedin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Osilodrostat, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Ranitidine, Reserpine, Rucaparib, Salmeterol, Saquinavir, Tirbanibulin, Verapamil

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 1 inhibitor
1	Solute carrier family 22 member 1 substrates	Acetylcholine, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Formoterol, Ganciclovir, Guanfacine, Imatinib, Lamivudine, Lamotrigine, Metformin, Nafamostat, Nintedanib, Norepinephrine, Pancuronium, Phenformin, Pramipexole, Prazosin, Quinine, Ranitidine, Rocuronium, Salmeterol, Spermidine, Spermine, Sulpiride, Thiamine, Tubocurarine
2	Solute carrier family 22 member 1 inhibitors	Amantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Formoterol, Ganciclovir, Gilteritinib, Guanfacine, Guanidine, Indinavir, Lasmiditan, Levofloxacin, Linagliptin, Lurbinectedin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Osilodrostat, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Ranitidine, Reserpine, Rucaparib, Salmeterol, Saquinavir, Tirbanibulin, Verapamil

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 6 substrate
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acamprosate, Acetazolamide, Acetylsalicylic acid, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acamprosate, Acetylcysteine, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 8 substrate
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine

	Interacting Group	Interacting Drugs
	Acyclovir is a Solute carrier family 22 member 8 inhibitor
1	Solute carrier family 22 member 8 inhibitors	Acetylsalicylic acid, Aminohippuric acid, Apalutamide, Artesunate, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Favipiravir, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Hydroflumethiazide, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Novobiocin, Osilodrostat, Ouabain, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rimegepant, Rosuvastatin, Rucaparib, Salicylic acid, Tafamidis, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2	Solute carrier family 22 member 8 inducers	Methyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3	Solute carrier family 22 member 8 substrates	Acamprosate, Allopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Betamethasone phosphate, Budesonide, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cortisone acetate, Cyclic adenosine monophosphate, Dexamethasone, Dexamethasone acetate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Empagliflozin, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Hydroflumethiazide, Leucovorin, Levocarnitine, Medrysone, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Oxytetracycline, Pemetrexed, Piperacillin, Polythiazide, Pravastatin, Prednisolone phosphate, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine

	Interacting Group	Interacting Drugs
	Acyclovir is a Ileal sodium/bile acid cotransporter substrate
1	Ileal sodium/bile acid cotransporter substrates	Cholic Acid, Glycochenodeoxycholic Acid, Taurocholic acid, Valaciclovir
2	Ileal sodium/bile acid cotransporter inducers	Cholic Acid, Taurocholic acid
3	Ileal sodium/bile acid cotransporter inhibitors	Cholic Acid, Cyclosporine, Deoxycholic acid, Levamlodipine, Ursodeoxycholic acid, Volixibat

	Interacting Group	Interacting Drugs
	Acyclovir is a Multidrug and toxin extrusion protein 1 substrate
1	Multidrug and toxin extrusion protein 1 substrates	Cefradine, Cephalexin, Cimetidine, Ciprofloxacin, Emtricitabine, Estrone sulfate, Flecainide, Ganciclovir, Guanidine, Levofloxacin, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Sulpiride, Tetraethylammonium, Tipiracil, Topotecan, Trimethoprim
2	Multidrug and toxin extrusion protein 1 inhibitors	Abemaciclib, Apalutamide, Bictegravir, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Famotidine, Fedratinib, Flecainide, Gilteritinib, Glasdegib, Guanfacine, Istradefylline, Lasmiditan, Levofloxacin, Lofexidine, Methylene blue, Osilodrostat, Pemigatinib, Pexidartinib, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Remdesivir, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Rucaparib, Selpercatinib, Tafenoquine, Tazemetostat, Tirbanibulin, Topotecan, Trilaciclib, Trimethoprim, Tucatinib, Verapamil

	Interacting Group	Interacting Drugs
	Acyclovir is a Multidrug and toxin extrusion protein 2 substrate
1	Multidrug and toxin extrusion protein 2 substrates	Baricitinib, Cimetidine, Estrone sulfate, Ganciclovir, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Sulpiride, Topotecan, Trastuzumab deruxtecan, Trimethoprim
2	Multidrug and toxin extrusion protein 2 inhibitors	Abemaciclib, Apalutamide, Baricitinib, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Copanlisib, Fedratinib, Glasdegib, Istradefylline, Lasmiditan, Levofloxacin, Methylene blue, Pexidartinib, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Risdiplam, Rucaparib, Tafenoquine, Tazemetostat, Tirbanibulin, Trilaciclib, Trimethoprim, Tucatinib, Verapamil