Emergency Contraception (DBCOND0033839)

Identifiers

Synonyms

Contraception, Postcoital / Postcoital Contraception / Post-coital contraception / Emergency contraception therapy / Post coital contraception / Emergency contraception / Postcoital contraceptive procedure (procedure) / Uses postcoital contraception (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Copper	A transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).	Superoxide dismutase [Cu-Zn]enzyme Diamine oxidase [copper-containing]enzyme Protein-lysine 6-oxidaseenzyme High affinity copper uptake protein 1transporter Natural resistance-associated macrophage protein 2transporter Albumincarrier Alpha-2-macroglobulincarrier Ceruloplasmincarrier Copper transport protein ATOX1carrier Copper-transporting ATPase 1transporter Copper-transporting ATPase 2transporter Copper chaperone for superoxide dismutasecarrier Cytochrome c oxidase copper chaperonecarrier Cytochrome c oxidase subunit 1enzyme Tyrosinaseenzyme Dopamine beta-hydroxylaseenzyme Peptidyl-glycine alpha-amidating monooxygenaseenzyme Monoamine oxidaseenzyme Angiogeninenzyme Amyloid-beta precursor proteintarget Hephaestincarrier Major prion proteinenzyme Adenosylhomocysteinasetarget Coagulation factor Vcarrier Coagulation factor VIIIcarrier Metallothioneincarrier Protein SLC31A2transporter Histone H2B type 1-C/E/F/G/Itarget Glyceraldehyde-3-phosphate dehydrogenasetarget Nucleoside diphosphate kinase Atarget Histone H1.4target Peroxiredoxin-1target Protein S100-A8target Small ribosomal subunit protein uS2target Actin, cytoplasmic 2target Alpha-enolasetarget Elongation factor 1-alpha 1target Keratin, type II cytoskeletal 8target Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target 60 kDa heat shock protein, mitochondrialtarget Heat shock 70 kDa protein 13target Endoplasmic reticulum chaperone BiPtarget Endoplasmintarget Serotransferrintarget Cell growth-regulating nucleolar proteintarget Small ribosomal subunit protein uS5target Serine/arginine-rich splicing factor 1target Heterogeneous nuclear ribonucleoproteins A2/B1target Heterogeneous nuclear ribonucleoprotein Htarget Heterogeneous nuclear ribonucleoprotein H3target Cobalt-precorrin-5B C(1)-methyltransferasetarget Heterogeneous nuclear ribonucleoprotein Ltarget Splicing factor, proline- and glutamine-richtarget Splicing factor 3A subunit 2target Small ribosomal subunit protein RACK1target Alpha-actinin-1target Aminoacylase-1target Annexin A4target Annexin A5target Calreticulintarget Pyruvate kinase PKMtarget Aldo-keto reductase family 1 member A1target NADH-cytochrome b5 reductase 3target Glutathione reductase, mitochondrialtarget Transketolasetarget Peroxiredoxin-2target Peroxiredoxin-6target Peptidyl-prolyl cis-trans isomerase Atarget Heat shock cognate 71 kDa proteintarget Heat shock protein HSP 90-alphatarget Prostaglandin E synthase 3target Stress-induced-phosphoprotein 1target Eukaryotic translation initiation factor 6target Eukaryotic initiation factor 4A-Itarget Glucose-6-phosphate isomerasetarget L-lactate dehydrogenase A chaintarget Phosphoglycerate kinase 1target Tubulin beta chaintarget Cofilin-1target 14-3-3 protein beta/alphatarget Aspartate aminotransferase, cytoplasmictarget Glutathione synthetasetarget Hepatoma-derived growth factortarget Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget Chloride intracellular channel protein 1target Proteasome activator complex subunit 1target Phosphatidylethanolamine-binding protein 1target Phosphoglycerate mutase 1target Ran-specific GTPase-activating proteintarget UDP-glucose 6-dehydrogenasetarget Beta-2-microglobulintarget Protein SCO1 homolog, mitochondrialtarget Alternative prion proteintarget Glycine receptor subunit alpha-1target Huntingtintarget Endonuclease 8-like 1target Endonuclease 8-like 2target Ferroxidase HEPHL1target Plasminogen activator inhibitor 1target Protein S100-A2target Protein S100-A4target Alpha-synucleintarget Brain-derived neurotrophic factortarget Parkinson disease protein 7target Islet amyloid polypeptidetarget Tachykinin-3target Alpha-1B-glycoproteintarget Afamintarget Angiotensinogentarget Alpha-2-HS-glycoproteintarget Serum amyloid P-componenttarget Apolipoprotein A-Itarget Apolipoprotein A-IItarget Apolipoprotein A-IVtarget Apolipoprotein B receptortarget Apolipoprotein C-IItarget Apolipoprotein C-IIItarget Apolipoprotein Dtarget Apolipoprotein Etarget Beta-2-glycoprotein 1target Zinc-alpha-2-glycoproteintarget Complement C1q subcomponent subunit Ctarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget Complement C5target Complement component C8 beta chaintarget Complement component C9target Complement factor Htarget Complement factor Itarget Tetranectintarget Clusterintarget Prothrombintarget Complement component 1 Q subcomponent-binding protein, mitochondrialtarget Gelsolintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Chromobox protein homolog 5target Haptoglobin-related proteintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Immunoglobulin heavy constant gamma 1target Immunoglobulin heavy constant gamma 4target Immunoglobulin kappa variable 3-20target Immunoglobulin lambda-like polypeptide 1target Inter-alpha-trypsin inhibitor heavy chain H2target Kininogen-1target Keratin, type II cytoskeletal 1target Keratin, type I cytoskeletal 10target Keratin, type II cytoskeletal 2 epidermaltarget Keratin, type I cytoskeletal 9target Leucine-rich alpha-2-glycoproteintarget Lumicantarget N-acetylmuramoyl-L-alanine amidasetarget Plasminogentarget Serum paraoxonase/arylesterase 1target Platelet basic proteintarget Alpha-1-antitrypsintarget Kallistatintarget Corticosteroid-binding globulintarget Thyroxine-binding globulintarget Antithrombin-IIItarget Heparin cofactor 2target Pigment epithelium-derived factortarget Alpha-2-antiplasmintarget Plasma protease C1 inhibitortarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Tubulin alpha 3C/D chaintarget
Levonorgestrel	A progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives.	Progesterone receptortarget Estrogen receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenase 1target Cytochrome P450 3A4enzyme Androgen receptortarget Sex hormone-binding globulintarget Glucocorticoid receptortarget Cytochrome P450 3A5enzyme
Norgestrel	A progestin used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women.	Progesterone receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenase 1target Androgen receptortarget Cytochrome P450 3A4enzyme Aromataseenzyme
Ulipristal	A selective progesterone receptor modulator used for emergency contraception after unprotected intercourse or in a situation where a planned method of contraception has failed.	Progesterone receptortarget Glucocorticoid receptortarget Androgen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01096498	Cross -Over Study to Prove Bioequivalence Between Two Oral Formulations of Levonorgestrel	Levonorgestrel	Not Available	1	completed
NCT01096485	Cross-over Study to Prove Bioequivalence Between Two Oral Formulations of Levonorgestrel	Levonorgestrel	Not Available	1	completed
NCT01320709	Effect of Piroxicam on Ovulation	Piroxicam	Not Available	2	completed
NCT01771016	Emergency Contraception - User's Profile	No drug interventions	Not Available	Not Available	completed
NCT03120728	Application for the Etonogestrel/Ethinyl Estradiol Ring	Ethinylestradiol Etonogestrel	prevention	4	unknown_status
NCT06162611	Etonogestrel (ENG) Implant Insertion for Emergency Contraception With Oral Levonorgestrel (LNG) vs Placebo	Etonogestrel Levonorgestrel	prevention	4	recruiting
NCT00777556	Emergency Contraception Actual Use Study	Levonorgestrel	treatment	3	completed
NCT03208985	A Study of Use of Ella®, an Emergency Contraceptive, Under Simulated OTC Conditions	Ulipristal	other	3	completed
NCT01569737	Clinical Follow-up and Outcomes of Pregnancies Exposed to Ella	No drug interventions	Not Available	Not Available	completed
NCT01569113	Assessment of Effects on Ovarian Activity of a Combined Oral Contraceptive Pill When Preceded by the Intake of ellaOne® or Placebo.	Ethinylestradiol Levonorgestrel Ulipristal	treatment	4	completed
NCT02076217	Quick Start of Highly Effective Contraception	Copper Levonorgestrel Medroxyprogesterone acetate	Not Available	Not Available	active_not_recruiting
NCT02078414	Continued Use of Effective Contraception After Use of Emergency Contraception	No drug interventions	Not Available	Not Available	completed
NCT00677755	Medical Abortion for Emergency Contraception Failure	Mifepristone Misoprostol	treatment	Not Available	completed
NCT00411684	Safety and Efficacy of CDB-2914 for Emergency Contraception	Ulipristal	treatment	3	completed
NCT04172584	Awareness & Use of Emergency Contraception	No drug interventions	Not Available	Not Available	unknown_status
NCT00271583	Efficacy Trial of CDB 2914 for Emergency Contraception	Levonorgestrel Ulipristal	treatment	2 / 3	completed
NCT03395756	Depot Medroxyprogesterone Acetate as Emergency Contraception	No drug interventions	prevention	0	completed
NCT03614494	Piroxicam and Levonorgestrel Co-treatment for Emergency Contraception	Levonorgestrel Piroxicam	treatment	2 / 3	completed
NCT01963962	Study of the Copper IUD or Oral Levonorgestrel and the Levonorgestrel IUD for Women Seeking Emergency Contraception	Copper Levonorgestrel	Not Available	Not Available	completed