Vitamin Deficiency (DBCOND0050977)

Identifiers

Synonyms

Deficiency Vitamins / Deficiency, Vitamin / Vitamin Deficiencies / Hypovitaminosis / Deficiency vitamin / Vitamin deficiency / Vitamin deficiency, unspecified / Hypovitaminosis NOS / Unspecified vitamin deficiency / Vitamin deficiency (disorder) / Vitamin deficiency NOS / Avitaminosis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ascorbic acid	A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.	Prolyl 4-hydroxylase subunit alpha-1target Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1target Hyaluronate lyasetarget DNAtarget Xylose isomerasetarget Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2target Phytanoyl-CoA dioxygenase, peroxisomaltarget Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3target Gamma-butyrobetaine dioxygenasetarget Dopamine beta-hydroxylasetarget Peptidyl-glycine alpha-amidating monooxygenasetarget Prolyl 3-hydroxylase 1target 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target DNA oxidative demethylase ALKBH2target Prolyl 3-hydroxylase 2target Prolyl 3-hydroxylase 3target Prolyl 3-hydroxylase OGFOD1target Prolyl hydroxylase EGLN2target Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3target Lysine-specific demethylase 5Dtarget Egl nine homolog 1target Prolyl hydroxylase EGLN3target Trimethyllysine dioxygenase, mitochondrialtarget Transmembrane prolyl 4-hydroxylasetarget Solute carrier family 23 member 1transporter Solute carrier family 23 member 2transporter Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Albumincarrier Thioredoxin reductase 1, cytoplasmicenzyme Solute carrier family 23 member 2target Solute carrier family 23 member 1target
Biotin	A B-complex vitamin found in many multivitamin products.	Propionyl-CoA carboxylase beta chain, mitochondrialtarget Biotin--protein ligasetarget Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialtarget Acetyl-CoA carboxylase 2target Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialtarget Pyruvate carboxylase, mitochondrialtarget Propionyl-CoA carboxylase alpha chain, mitochondrialtarget Acetyl-CoA carboxylase 1target Cytochrome P450 1B1enzyme Sodium-dependent multivitamin transportertransporter Sodium-coupled monocarboxylate transporter 1transporter
Cholecalciferol	A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.	Vitamin D-binding proteincarrier Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Vitamin D 25-hydroxylaseenzyme Sterol 26-hydroxylase, mitochondrialenzyme Cytochrome P450 2J2enzyme Cytochrome P450 3A4enzyme Vitamin D3 receptortarget Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme
Cobaltous sulfate	A micronutrient found in some multivitamins.	No drug targets
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
DL-alpha tocopheryl acetate	Not Annotated	No drug targets
DL-alpha-Tocopherol	Not Annotated	No drug targets
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Flavin mononucleotide	A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia.	Flavin reductase (NADPH)target 2-Hydroxyacid oxidase 1target Pyridoxine-5'-phosphate oxidasetarget Major NAD(P)H-flavin oxidoreductasetarget Riboflavin kinasetarget Oxygen-insensitive NADPH nitroreductasetarget Nitric oxide synthase 1target Dihydroorotate dehydrogenase (quinone)target Dihydropyrimidine dehydrogenase [NADP(+)]target Dihydroorotate dehydrogenase (quinone), mitochondrialtarget Flavodoxintarget Oxygen-insensitive NAD(P)H nitroreductasetarget Chorismate synthasetarget 2,4-dienoyl-CoA reductase [NADPH]target Dihydroorotate dehydrogenase A (fumarate)target Pyridoxine/pyridoxamine 5'-phosphate oxidasetarget Pentaerythritol tetranitrate reductasetarget FMN-dependent NADH-azoreductasetarget Epidermin decarboxylasetarget FMN-dependent NADH-azoreductasetarget Chorismate synthasetarget Flavodoxintarget Flavodoxintarget Flavodoxintarget Uncharacterized proteintarget Putative monooxygenase MoxCtarget tRNA-dihydrouridine synthasetarget Protein NrdItarget Probable UbiX-like flavin prenyltransferasetarget (S)-mandelate dehydrogenasetarget FMN-dependent NADPH-azoreductasetarget Flavodoxintarget Serine/threonine-protein kinase Sgk1target Oxygen-insensitive NAD(P)H nitroreductasetarget Nitric oxide reductasetarget Isopentenyl-diphosphate delta-isomerasetarget Trimethylamine dehydrogenasetarget Rubredoxin-oxygen oxidoreductasetarget Riboflavin biosynthesis proteintarget Morphinone reductasetarget NADPH-flavin oxidoreductasetarget Ribosomal protein S6 kinase alpha-4target Phenazine biosynthesis protein PhzGtarget 2-Hydroxyacid oxidase 2target NAD(P)H dehydrogenase (quinone)target Flavodoxin-1target Isopentenyl-diphosphate delta-isomerasetarget NADH dehydrogenasetarget FMN-binding proteintarget Nitroreductase family proteintarget NADPH--cytochrome P450 reductasetarget Phosphopantothenoylcysteine decarboxylasetarget Phenazine biosynthesis proteintarget Ferredoxin-dependent glutamate synthase 2target NADPH--cytochrome P450 reductaseenzyme
Folic acid	A nutrient used to treat megaloblastic anemia and is found in many supplements.	Folate receptor gammatarget Folate receptor betatarget Methylenetetrahydrofolate reductase (NADPH)enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Proton-coupled folate transportertransporter Solute carrier family 25 member 32transporter Gamma-glutamyl hydrolaseenzyme Folate receptor alphatarget Dihydrofolate reductaseenzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Iron polymaltose	Not Annotated	No drug targets
Nicotinamide	An ingredient found in a variety of cosmetic products.	NAD-dependent protein deacylase sirtuin-5, mitochondrialtarget ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2target Exotoxin Atarget L-lactate dehydrogenase A chaintarget Poly [ADP-ribose] polymerase 1target Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget
Riboflavin	A vitamin used to correct vitamin B2 deficiency.	Flavin reductase (NADPH)target Riboflavin kinasetarget Riboflavin synthasetarget Amine oxidase [flavin-containing] Aenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Solute carrier family 22 member 6transporter
Thiamine	A vitamin used to correct vitamin B1 deficiency.	Thiamine pyrophosphokinase 1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter Cytochrome P450 4B1enzyme Thiamine transporter 1transporter Thiamine transporter 2transporter Thiamine pyrophosphokinase 1enzyme Nucleoside diphosphate phosphatase ENTPD5enzyme Thiamine-triphosphataseenzyme Albumincarrier Pyruvate dehydrogenase E1 componenttarget
Vitamin A	A vitamin important for retinal function that is used clinically to correct vitamin A deficiency.	Retinol dehydrogenase 12target Retinol dehydrogenase 5target Retinol dehydrogenase 13target Retinol-binding protein 5carrier Retinoid-binding protein 7carrier Retinol-binding protein 4carrier Retinol-binding protein 2carrier Retinal dehydrogenase 2target Aldehyde dehydrogenase 1A1target Lecithin retinol acyltransferasetarget Short-chain dehydrogenase/reductase 3target Retinaldehyde dehydrogenase 3target All-trans-retinol 13,14-reductasetarget Retinol dehydrogenase 11target Dehydrogenase/reductase SDR family member 4target Retinol dehydrogenase 14target Retinol dehydrogenase 8target Cytochrome P450 26A1enzyme Apolipoprotein Dtarget Prostaglandin-H2 D-isomerasetarget Albumincarrier Retinaldehyde-binding protein 1carrier Retinol-binding protein 3carrier Retinol-binding protein 1carrier Receptor for retinol uptake STRA6transporter Retinoic acid receptor RXR-gammatarget
Vitamin E	An antioxidant vitamin used in many skin creams and multivitamin preparations.	SEC14-like protein 4target SEC14-like protein 3target SEC14-like protein 2target Nuclear receptor subfamily 1 group I member 2target Protein kinase C beta typetarget Polyunsaturated fatty acid 5-lipoxygenasetarget Protein kinase C alpha typetarget Diacylglycerol kinase alphatarget Serine/threonine-protein phosphatase 2A catalytic subunit beta isoformtarget Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformtarget Alpha-tocopherol transfer proteincarrier Glutathione S-transferase A2enzyme Glutathione S-transferase Penzyme Glutathione S-transferase omega-1enzyme Glutathione S-transferase Mu 3enzyme Glutamate--cysteine ligase catalytic subunitenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Heme oxygenase 1enzyme Superoxide dismutase [Cu-Zn]enzyme Scavenger receptor class B member 1transporter Phospholipid-transporting ATPase ABCA1transporter NPC1-like intracellular cholesterol transporter 1transporter ATP-binding cassette sub-family G member 1transporter SEC14-like protein 2carrier SEC14-like protein 3carrier Phospholipid transfer proteincarrier Cytochrome P450 3A4enzyme
alpha-Tocopherol acetate	A form of vitamin E used to treat and prevent vitamin deficiencies.	Cytochrome P450 4F2enzyme Cytochrome P450 3A4enzyme Free radicalstarget Alpha-tocopherol transfer proteintransporter SEC14-like protein 4transporter SEC14-like protein 2transporter SEC14-like protein 3transporter Apolipoprotein B receptortransporter Scavenger receptor class B member 1transporter ATP-dependent translocase ABCB1transporter Very low-density lipoprotein receptorcarrier Low-density lipoprotein receptorcarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03272022	Micronutrient Status During Pregnancy	No drug interventions	Not Available	Not Available	completed
NCT03542591	Supplementation of Critical Nutrients in a Plant-based Diet	No drug interventions	Not Available	Not Available	completed
NCT01630720	Vitamin Therapy in JGH Patients	No drug interventions	treatment	2	completed
NCT04673721	PROSPective Evaluation of Fortified Eggs Related to Improvement in The Biomarker Profile for Your Health	No drug interventions	other	Not Available	completed
NCT01653353	Swiss Study on Vitamin D and Calcium in Nursing Homes	No drug interventions	prevention	Not Available	completed
NCT04054505	Effectiveness of a Nutraceutical in Raising Circulating Serum Vitamin, Mineral and Amino Acid Levels in Patients.	No drug interventions	health_services_research	Not Available	completed
NCT01263288	Effect of Vitamin D Supplementation on Muscular Strength, Musculoskeletal Pain and Headache	No drug interventions	prevention	4	completed
NCT02272842	Vitamin B12, Neurodevelopment and Growth in Nepal	No drug interventions	prevention	2 / 3	active_not_recruiting
NCT03360435	Absorption of Transdermal Vitamins in Post Bariatric Surgery Patients	No drug interventions	Not Available	Not Available	completed
NCT06372366	Relationship Between Vitamins Deficiency and Caries Experience Among a Group of Egyptian Children	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03146273	Study of Absorption Characteristics of Two Multivitamin Mineral Formulations (Gel vs. Tablet/Capsule)	No drug interventions	prevention	Not Available	unknown_status
NCT01609387	Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study)	No drug interventions	treatment	4	completed
NCT03004807	Role of Centrum® Silver® in Improving Micronutrient Status in Older Men	No drug interventions	basic_science	Not Available	unknown_status
NCT04587076	Evaluation of Protein Intake and Micronutrient Supplementation After Bariatric Surgery	No drug interventions	Not Available	Not Available	completed
NCT06323538	Cohort Study on Plant-based Diets (COPLANT Study)	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00599352	Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease Patients	No drug interventions	diagnostic	Not Available	terminated
NCT00742937	Impact of Maternal Supplementation With Dual Megadose of Vitamin A	No drug interventions	prevention	2 / 3	completed
NCT05122481	Vitamin C 4 Care Homes	No drug interventions	other	Not Available	unknown_status